Ensembl ID ENSG00000086232 Gene ID 27102 Accession 24921
Gene Symbol EIF2AK1 Alias HCR;HRI;hHRI;LEMSPAD Full Name eukaryotic translation initiation factor 2 alpha kinase 1
Position 7 : 6022247 - 6059175 Length 36929 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Non-canonical_RBPs
Summary The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

ENSG00000086232 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000086232 EIF2AK1 0.97 6.84e-23 BLCA
ENSG00000086232 EIF2AK1 0.87 2.23e-89 BRCA
ENSG00000086232 EIF2AK1 0.77 5.63e-25 KICH
ENSG00000086232 EIF2AK1 0.78 3.59e-35 LUSC
ENSG00000086232 EIF2AK1 0.57 6.36e-23 PRAD
ENSG00000086232 EIF2AK1 0.96 5.16e-46 UCEC
ENSG00000086232 EIF2AK1 0.98 1.34e-49 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000086232 EIF2AK1 colon cancer 10473109
ENSG00000086232 EIF2AK1 colon cancer 10500066
ENSG00000086232 EIF2AK1 cancer 11101152
ENSG00000086232 EIF2AK1 colon cancer 17472962
ENSG00000086232 EIF2AK1 breast cancer 18559534
ENSG00000086232 EIF2AK1 breast cancer 18815881
ENSG00000086232 EIF2AK1 tumor 2032217
ENSG00000086232 EIF2AK1 cancer 20429927
ENSG00000086232 EIF2AK1 Cancer 21765405
ENSG00000086232 EIF2AK1 tumor 23209575
ENSG00000086232 EIF2AK1 GBM 23577178
ENSG00000086232 EIF2AK1 cancer 25086227
ENSG00000086232 EIF2AK1 cancer 25311023
ENSG00000086232 EIF2AK1 tumors 25506833
ENSG00000086232 EIF2AK1 cancer 26879161
ENSG00000086232 EIF2AK1 tumor 29063813
ENSG00000086232 EIF2AK1 pancreatic cancer 29720726
ENSG00000086232 EIF2AK1 Cancer of the Pancreas 30145314
ENSG00000086232 EIF2AK1 pancreatic cancer 31558858
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000086232 EIF2AK1 MESO 0.042 high
ENSG00000086232 EIF2AK1 SARC 0.014 high
ENSG00000086232 EIF2AK1 CHOL 0.00014 low
ENSG00000086232 EIF2AK1 UVM 0.0026 high
ENSG00000086232 EIF2AK1 HNSC 0.0088 high
ENSG00000086232 EIF2AK1 KIRP 0.024 high
ENSG00000086232 EIF2AK1 BRCA 0.0065 high
ENSG00000086232 EIF2AK1 COAD 0.033 high
ENSG00000086232 EIF2AK1 UCS 0.0083 high
ENSG00000086232 EIF2AK1 ESCA 0.02 high
ENSG00000086232 EIF2AK1 OV 0.02 low
ENSG00000086232 EIF2AK1 KIRC 0.012 high
ENSG00000086232 EIF2AK1 BLCA 0.0097 high
ENSG00000086232 EIF2AK1 GBM 0.047 high
ENSG00000086232 EIF2AK1 CESC 0.018 high
ENSG00000086232 EIF2AK1 LIHC 0.00026 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000086232 EIF2AK1 SKCM Amp 3.598737 0.206229 0.719087 0.569482
ENSG00000086232 EIF2AK1 TGCT Amp 1.710327 0.165017 0.555449 0.840000
ENSG00000086232 EIF2AK1 BLCA Amp 0.855770 0.170050 0.489424 0.475490
ENSG00000086232 EIF2AK1 STAD Amp 1.015089 0.141356 0.505423 0.521542
ENSG00000086232 EIF2AK1 UCEC Del 1.292632 0.055639 0.490024 0.116883
ENSG00000086232 EIF2AK1 OV Del 24.319114 0.412492 0.628443 0.435233