Ensembl ID ENSG00000086102 Gene ID 4799 Accession 7803
Gene Symbol NFX1 Alias NFX2;Tex42;TEG-42 Full Name nuclear transcription factor, X-box binding 1
Position 9 : 33290516 - 33371157 Length 80642 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]

ENSG00000086102 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000086102 NFX1 GBM 23592437
ENSG00000086102 NFX1 tumors 25724086
ENSG00000086102 NFX1 cancers 29117186
ENSG00000086102 NFX1 gastric cancer 30288832
ENSG00000086102 NFX1 cancer 30416686
ENSG00000086102 NFX1 cervical cancer 30776478
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000086102 NFX1 MESO 0.0022 low
ENSG00000086102 NFX1 SARC 0.0073 high
ENSG00000086102 NFX1 STAD 0.029 low
ENSG00000086102 NFX1 CHOL 0.039 low
ENSG00000086102 NFX1 UVM 0.026 high
ENSG00000086102 NFX1 PAAD 0.031 low
ENSG00000086102 NFX1 ACC 0.0027 high
ENSG00000086102 NFX1 LUSC 0.044 low
ENSG00000086102 NFX1 HNSC 0.019 low
ENSG00000086102 NFX1 KIRP 0.00099 low
ENSG00000086102 NFX1 KICH 0.016 high
ENSG00000086102 NFX1 LUAD 0.0067 low
ENSG00000086102 NFX1 PCPG 0.0025 low
ENSG00000086102 NFX1 BRCA 0.027 low
ENSG00000086102 NFX1 COAD 0.0028 high
ENSG00000086102 NFX1 UCS 0.0028 high
ENSG00000086102 NFX1 ESCA 0.02 low
ENSG00000086102 NFX1 OV 0.00082 low
ENSG00000086102 NFX1 TGCT 0.013 high
ENSG00000086102 NFX1 BLCA 0.01 low
ENSG00000086102 NFX1 LAML 0.016 high
ENSG00000086102 NFX1 GBM 0.011 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000086102 NFX1 LUSC Amp 8.072687 0.365333 0.693876 0.279441
ENSG00000086102 NFX1 GBM Del 2.508748 0.072239 0.628801 0.343154
ENSG00000086102 NFX1 HNSC Amp 2.180758 0.151262 0.599734 0.247126
ENSG00000086102 NFX1 STAD Amp 1.144900 0.145489 0.532727 0.195011