Ensembl ID
ENSG00000086102
Gene ID
4799
Accession
7803
Gene Symbol
NFX1
Alias
NFX2;Tex42;TEG-42
Full Name
nuclear transcription factor, X-box binding 1
Position
9 : 33290516 - 33371157
Length
80642 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs mRNA RBP type
Canonical_RBPs
Summary
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]
ENSG00000086102 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000086102
NFX1
GBM
23592437
ENSG00000086102
NFX1
tumors
25724086
ENSG00000086102
NFX1
cancers
29117186
ENSG00000086102
NFX1
gastric cancer
30288832
ENSG00000086102
NFX1
cancer
30416686
ENSG00000086102
NFX1
cervical cancer
30776478
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000086102
NFX1
MESO
0.0022
low
show
ENSG00000086102
NFX1
SARC
0.0073
high
show
ENSG00000086102
NFX1
STAD
0.029
low
show
ENSG00000086102
NFX1
CHOL
0.039
low
show
ENSG00000086102
NFX1
UVM
0.026
high
show
ENSG00000086102
NFX1
PAAD
0.031
low
show
ENSG00000086102
NFX1
ACC
0.0027
high
show
ENSG00000086102
NFX1
LUSC
0.044
low
show
ENSG00000086102
NFX1
HNSC
0.019
low
show
ENSG00000086102
NFX1
KIRP
0.00099
low
show
ENSG00000086102
NFX1
KICH
0.016
high
show
ENSG00000086102
NFX1
LUAD
0.0067
low
show
ENSG00000086102
NFX1
PCPG
0.0025
low
show
ENSG00000086102
NFX1
BRCA
0.027
low
show
ENSG00000086102
NFX1
COAD
0.0028
high
show
ENSG00000086102
NFX1
UCS
0.0028
high
show
ENSG00000086102
NFX1
ESCA
0.02
low
show
ENSG00000086102
NFX1
OV
0.00082
low
show
ENSG00000086102
NFX1
TGCT
0.013
high
show
ENSG00000086102
NFX1
BLCA
0.01
low
show
ENSG00000086102
NFX1
LAML
0.016
high
show
ENSG00000086102
NFX1
GBM
0.011
low
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000086102
NFX1
LUSC
Amp
8.072687
0.365333
0.693876
0.279441
ENSG00000086102
NFX1
GBM
Del
2.508748
0.072239
0.628801
0.343154
ENSG00000086102
NFX1
HNSC
Amp
2.180758
0.151262
0.599734
0.247126
ENSG00000086102
NFX1
STAD
Amp
1.144900
0.145489
0.532727
0.195011
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