Ensembl ID ENSG00000085733 Gene ID 2017 Accession 3338
Gene Symbol CTTN Alias EMS1 Full Name cortactin
Position 11 : 70398404 - 70436584 Length 38181 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

ENSG00000085733 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000085733 0.79 1.31e-21 BRCA
ENSG00000085733 0.28 1.49e-11 PRAD
ENSG00000085733 0.59 5.28e-16 KIRP
ENSG00000085733 0.59 3.52e-13 LIHC
ENSG00000085733 0.81 1.47e-25 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000085733 cancers 10537323
ENSG00000085733 breast cancer 10706127
ENSG00000085733 tumor 10955801
ENSG00000085733 breast cancer 11250710
ENSG00000085733 tumor 11568558
ENSG00000085733 cancers 12552080
ENSG00000085733 bladder tumors 12739008
ENSG00000085733 breast cancer 12755491
ENSG00000085733 esophageal cancer 12792807
ENSG00000085733 tumors 14499691
ENSG00000085733 urinary bladder cancer 14648664
ENSG00000085733 breast cancer 15355907
ENSG00000085733 head and neck tumors 15585574
ENSG00000085733 tumours 15682439
ENSG00000085733 cancers 15833860
ENSG00000085733 bladder tumors 15942670
ENSG00000085733 tumors 16235239
ENSG00000085733 breast cancer 16536875
ENSG00000085733 breast cancer 16652145
ENSG00000085733 tumors 16906560
ENSG00000085733 HNSCC 16912177
ENSG00000085733 tumor 17005439
ENSG00000085733 HNSCC 17065789
ENSG00000085733 tumor 17178864
ENSG00000085733 colon cancer 17192196
ENSG00000085733 cancer 17487429
ENSG00000085733 HNSCC 17909038
ENSG00000085733 HNSCC 18268492
ENSG00000085733 tumor 18334127
ENSG00000085733 HNSCC 18607838
ENSG00000085733 breast cancer 18823530
ENSG00000085733 tumor 18931703
ENSG00000085733 tumour 18991334
ENSG00000085733 tumor 19125793
ENSG00000085733 tumor 19684620
ENSG00000085733 HNSCC 20149059
ENSG00000085733 breast cancer 20213079
ENSG00000085733 head and neck cancer 20443891
ENSG00000085733 gastric cancer 20579220
ENSG00000085733 tumor 21395182
ENSG00000085733 colon cancer 21418910
ENSG00000085733 tumor 21419472
ENSG00000085733 lung cancer 21503569
ENSG00000085733 tumor 21562571
ENSG00000085733 tumor 21637470
ENSG00000085733 laryngeal cancer 21646305
ENSG00000085733 colorectal cancer 22116727
ENSG00000085733 tumor 22127891
ENSG00000085733 tumor 22171072
ENSG00000085733 colorectal cancer 22403749
ENSG00000085733 breast cancers 22654484
ENSG00000085733 cancer 23518204
ENSG00000085733 laryngeal cancers 23652995
ENSG00000085733 tumor 23957735
ENSG00000085733 HNSCCs 24278325
ENSG00000085733 colon cancer 24465712
ENSG00000085733 Esophageal Cancer 24551190
ENSG00000085733 cancer 24930674
ENSG00000085733 esophageal cancers 25205106
ENSG00000085733 esophageal cancer 25212831
ENSG00000085733 gastric cancer 26236696
ENSG00000085733 tumors 26257336
ENSG00000085733 tumor 26369414
ENSG00000085733 tumors 26952924
ENSG00000085733 tumor 27025610
ENSG00000085733 lung cancer 27026610
ENSG00000085733 Breast cancer 27081087
ENSG00000085733 tumor 27148699
ENSG00000085733 cancer 27390607
ENSG00000085733 tumor 27501229
ENSG00000085733 tumor 27566955
ENSG00000085733 tumor 27603901
ENSG00000085733 colorectal cancer 27633051
ENSG00000085733 oral cancer 27653309
ENSG00000085733 GBM 27672311
ENSG00000085733 HNSCC 27764170
ENSG00000085733 tumor 27877079
ENSG00000085733 cancer 27903975
ENSG00000085733 colorectal cancer 28404950
ENSG00000085733 cancer 28419476
ENSG00000085733 tumors 29123240
ENSG00000085733 tumors 29152154
ENSG00000085733 cancer 29221118
ENSG00000085733 laryngeal cancer 29654156
ENSG00000085733 gastric cancer 29733519
ENSG00000085733 breast cancer 29774130
ENSG00000085733 tumor 29872504
ENSG00000085733 lung cancer 29986736
ENSG00000085733 tumor 30220969
ENSG00000085733 breast cancer 30353022
ENSG00000085733 HNSCC 30456890
ENSG00000085733 tumors 30497530
ENSG00000085733 HNSCC 30513772
ENSG00000085733 cancers 30804117
ENSG00000085733 tumor 30832692
ENSG00000085733 Cancer 30862794
ENSG00000085733 cancer 31109222
ENSG00000085733 tumor 7598859
ENSG00000085733 breast cancer 7819270
ENSG00000085733 tumors 7905628
ENSG00000085733 tumor 8217084
ENSG00000085733 breast cancer 8474448
ENSG00000085733 tumours 8622895
ENSG00000085733 breast cancer 8945620
ENSG00000085733 tumor 9109790
ENSG00000085733 tumors 9309140
ENSG00000085733 breast cancer 9380415
ENSG00000085733 tumors 9533029
ENSG00000085733 breast cancer 9681820
ENSG00000085733 breast cancer 9747885
ENSG00000085733 tumor 9823470
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000085733 MESO 0.018 low
ENSG00000085733 STAD 0.042 low
ENSG00000085733 UVM 0.00077 high
ENSG00000085733 PAAD 0.00048 high
ENSG00000085733 THCA 0.0044 low
ENSG00000085733 LGG 0.015 high
ENSG00000085733 LUSC 0.04 high
ENSG00000085733 READ 0.013 low
ENSG00000085733 KIRP 0.0068 low
ENSG00000085733 THYM 0.00018 high
ENSG00000085733 ESCA 0.043 high
ENSG00000085733 KIRC 0.0015 high
ENSG00000085733 LAML 0.018 low
ENSG00000085733 SKCM 0.046 high
ENSG00000085733 CESC 0.018 high
ENSG00000085733 LIHC 0.00056 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000085733 LUSC Amp 73.309282 1.119196 1.404411 0.367265
ENSG00000085733 LUAD Amp 2.711302 0.163958 0.446790 0.321705
ENSG00000085733 CESC Amp 6.614219 0.299366 0.943767 0.135593
ENSG00000085733 ESCA Amp 94.790416 2.690809 2.118813 0.548913
ENSG00000085733 SKCM Amp 11.020084 0.374172 1.026996 0.174387
ENSG00000085733 HNSC Amp 246.015976 2.083581 2.055030 0.434866
ENSG00000085733 LIHC Amp 5.124945 0.209152 0.978394 0.110811
ENSG00000085733 BLCA Amp 28.203614 0.674253 1.063854 0.296569
ENSG00000085733 BRCA Amp 170.387714 1.132981 1.414828 0.352778
ENSG00000085733 STAD Amp 11.639762 0.354072 0.800704 0.247166
ENSG00000085733 PRAD Amp 2.749620 0.073534 0.542818 0.091463
ENSG00000085733 UCEC Amp 1.911664 0.131185 0.660255 0.109462
ENSG00000085733 OV Amp 7.300192 0.497592 0.735292 0.381693