carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Position
2 : 27217369 - 27243943
Length
26575 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs
N.A.
RBP type
Canonical_RBPs
Summary
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]