Ensembl ID ENSG00000084072 Gene ID 10450 Accession 9258
Gene Symbol PPIE Alias CYP33;CYP-33 Full Name peptidylprolyl isomerase E
Position 1 : 39692182 - 39763914 Length 71733 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]

ENSG00000084072 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000084072 PPIE 0.54 2.25e-11 LUSC
ENSG00000084072 PPIE 0.45 2.99e-12 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000084072 PPIE tumour 16458257
ENSG00000084072 PPIE cancer 30607259
ENSG00000084072 PPIE small cell lung cancer 9747881
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000084072 PPIE MESO 0.012 high
ENSG00000084072 PPIE SARC 0.013 high
ENSG00000084072 PPIE UVM 0.0019 high
ENSG00000084072 PPIE UCEC 0.021 high
ENSG00000084072 PPIE ACC 0.00012 high
ENSG00000084072 PPIE HNSC 0.045 high
ENSG00000084072 PPIE READ 0.016 low
ENSG00000084072 PPIE KIRP 0.0035 low
ENSG00000084072 PPIE KICH 0.0068 high
ENSG00000084072 PPIE LUAD 0.0084 low
ENSG00000084072 PPIE BRCA 0.028 high
ENSG00000084072 PPIE ESCA 0.036 high
ENSG00000084072 PPIE OV 0.0036 low
ENSG00000084072 PPIE BLCA 0.021 low
ENSG00000084072 PPIE GBM 0.025 high
ENSG00000084072 PPIE SKCM 0.0063 low
ENSG00000084072 PPIE CESC 0.03 high
ENSG00000084072 PPIE LIHC 0.00029 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000084072 PPIE CHOL Del 1.945317 0.306751 0.620861 0.305556
ENSG00000084072 PPIE LUAD Amp 0.720373 0.117231 0.398500 0.267442
ENSG00000084072 PPIE KIRP Del 1.613380 0.036088 0.601841 0.138889
ENSG00000084072 PPIE ESCA Amp 1.343236 0.300742 0.753171 0.206522
ENSG00000084072 PPIE LIHC Del 3.079271 0.099779 0.507670 0.300000
ENSG00000084072 PPIE PCPG Del 1.412846 0.073513 0.676188 0.629630
ENSG00000084072 PPIE BLCA Amp 7.384466 0.339581 0.748310 0.245098
ENSG00000084072 PPIE UCEC Amp 1.410696 0.120412 0.546458 0.126160
ENSG00000084072 PPIE UVM Del 1.628635 0.096085 0.809086 0.300000
ENSG00000084072 PPIE OV Amp 24.197398 0.750737 0.822284 0.504318