Ensembl ID
ENSG00000083520
Gene ID
22894
Accession
20604
Gene Symbol
DIS3
Alias
RRP44;dis3p;EXOSC11;KIAA1008;2810028N01Rik
Full Name
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Position
13 : 72752169 - 72782096
Length
29928 bases
Strand
Minus strand
Status
Confidence
Main interacting RNAs diverse RBP type
Canonical_RBPs
Summary
Enables 3'-5'-exoribonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]
ENSG00000083520 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000083520
DIS3
0.79
9.61e-19
COAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000083520
DIS3
AML
22237025
ENSG00000083520
DIS3
tumor
23551967
ENSG00000083520
DIS3
colorectal cancer
24478024
ENSG00000083520
DIS3
tumours
25521164
ENSG00000083520
DIS3
tumor
25925570
ENSG00000083520
DIS3
tumour
26193331
ENSG00000083520
DIS3
tumor
26305418
ENSG00000083520
DIS3
cancer
26517092
ENSG00000083520
DIS3
pancreatic cancer
28172817
ENSG00000083520
DIS3
tumors
28377632
ENSG00000083520
DIS3
cancers
29802118
ENSG00000083520
DIS3
cancer
30724665
ENSG00000083520
DIS3
tumor
9605876
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000083520
DIS3
MESO
0.0018
low
show
ENSG00000083520
DIS3
SARC
0.036
high
show
ENSG00000083520
DIS3
STAD
0.019
low
show
ENSG00000083520
DIS3
PAAD
0.0018
high
show
ENSG00000083520
DIS3
ACC
0.0038
high
show
ENSG00000083520
DIS3
LGG
0.014
low
show
ENSG00000083520
DIS3
LUSC
0.0054
low
show
ENSG00000083520
DIS3
HNSC
0.017
high
show
ENSG00000083520
DIS3
KICH
0.046
high
show
ENSG00000083520
DIS3
PCPG
0.032
low
show
ENSG00000083520
DIS3
DLBC
0.015
high
show
ENSG00000083520
DIS3
PRAD
0.0015
high
show
ENSG00000083520
DIS3
BLCA
0.035
high
show
ENSG00000083520
DIS3
SKCM
0.00065
low
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000083520
DIS3
LUSC
Del
0.723792
0.065694
0.377956
0.614770
ENSG00000083520
DIS3
LUAD
Del
0.898202
0.054133
0.324643
0.484496
ENSG00000083520
DIS3
LGG
Del
4.684184
0.072810
0.458123
0.267057
ENSG00000083520
DIS3
CESC
Amp
0.988508
0.140166
0.575409
0.169492
ENSG00000083520
DIS3
CESC
Del
1.339470
0.080006
0.427422
0.264407
ENSG00000083520
DIS3
READ
Amp
2.512767
0.212285
1.036572
0.727273
ENSG00000083520
DIS3
COAD
Amp
6.626536
0.165447
0.905077
0.598670
ENSG00000083520
DIS3
SARC
Del
7.139120
0.251916
0.596103
0.560311
ENSG00000083520
DIS3
GBM
Del
10.550115
0.128717
0.569757
0.398614
ENSG00000083520
DIS3
THCA
Del
1.956122
0.015404
0.597427
0.036072
ENSG00000083520
DIS3
HNSC
Amp
4.725732
0.198824
0.687136
0.164751
ENSG00000083520
DIS3
HNSC
Del
0.611129
0.052888
0.383691
0.323755
ENSG00000083520
DIS3
LIHC
Del
7.518098
0.145719
0.572571
0.370270
ENSG00000083520
DIS3
BLCA
Del
3.112834
0.113041
0.395926
0.250000
ENSG00000083520
DIS3
BRCA
Del
3.679523
0.085409
0.475267
0.403704
ENSG00000083520
DIS3
STAD
Amp
0.772296
0.132961
0.547317
0.380952
ENSG00000083520
DIS3
PRAD
Del
34.651643
0.269782
0.524412
0.353659
Copyright © 2023, Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.