Ensembl ID ENSG00000083520 Gene ID 22894 Accession 20604
Gene Symbol DIS3 Alias RRP44;dis3p;EXOSC11;KIAA1008;2810028N01Rik Full Name DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Position 13 : 72752169 - 72782096 Length 29928 bases Strand Minus strand
Status Confidence Main interacting RNAsdiverseRBP type Canonical_RBPs
Summary Enables 3'-5'-exoribonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]

ENSG00000083520 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000083520 DIS3 0.79 9.61e-19 COAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000083520 DIS3 AML 22237025
ENSG00000083520 DIS3 tumor 23551967
ENSG00000083520 DIS3 colorectal cancer 24478024
ENSG00000083520 DIS3 tumours 25521164
ENSG00000083520 DIS3 tumor 25925570
ENSG00000083520 DIS3 tumour 26193331
ENSG00000083520 DIS3 tumor 26305418
ENSG00000083520 DIS3 cancer 26517092
ENSG00000083520 DIS3 pancreatic cancer 28172817
ENSG00000083520 DIS3 tumors 28377632
ENSG00000083520 DIS3 cancers 29802118
ENSG00000083520 DIS3 cancer 30724665
ENSG00000083520 DIS3 tumor 9605876
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000083520 DIS3 MESO 0.0018 low
ENSG00000083520 DIS3 SARC 0.036 high
ENSG00000083520 DIS3 STAD 0.019 low
ENSG00000083520 DIS3 PAAD 0.0018 high
ENSG00000083520 DIS3 ACC 0.0038 high
ENSG00000083520 DIS3 LGG 0.014 low
ENSG00000083520 DIS3 LUSC 0.0054 low
ENSG00000083520 DIS3 HNSC 0.017 high
ENSG00000083520 DIS3 KICH 0.046 high
ENSG00000083520 DIS3 PCPG 0.032 low
ENSG00000083520 DIS3 DLBC 0.015 high
ENSG00000083520 DIS3 PRAD 0.0015 high
ENSG00000083520 DIS3 BLCA 0.035 high
ENSG00000083520 DIS3 SKCM 0.00065 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000083520 DIS3 LUSC Del 0.723792 0.065694 0.377956 0.614770
ENSG00000083520 DIS3 LUAD Del 0.898202 0.054133 0.324643 0.484496
ENSG00000083520 DIS3 LGG Del 4.684184 0.072810 0.458123 0.267057
ENSG00000083520 DIS3 CESC Amp 0.988508 0.140166 0.575409 0.169492
ENSG00000083520 DIS3 CESC Del 1.339470 0.080006 0.427422 0.264407
ENSG00000083520 DIS3 READ Amp 2.512767 0.212285 1.036572 0.727273
ENSG00000083520 DIS3 COAD Amp 6.626536 0.165447 0.905077 0.598670
ENSG00000083520 DIS3 SARC Del 7.139120 0.251916 0.596103 0.560311
ENSG00000083520 DIS3 GBM Del 10.550115 0.128717 0.569757 0.398614
ENSG00000083520 DIS3 THCA Del 1.956122 0.015404 0.597427 0.036072
ENSG00000083520 DIS3 HNSC Amp 4.725732 0.198824 0.687136 0.164751
ENSG00000083520 DIS3 HNSC Del 0.611129 0.052888 0.383691 0.323755
ENSG00000083520 DIS3 LIHC Del 7.518098 0.145719 0.572571 0.370270
ENSG00000083520 DIS3 BLCA Del 3.112834 0.113041 0.395926 0.250000
ENSG00000083520 DIS3 BRCA Del 3.679523 0.085409 0.475267 0.403704
ENSG00000083520 DIS3 STAD Amp 0.772296 0.132961 0.547317 0.380952
ENSG00000083520 DIS3 PRAD Del 34.651643 0.269782 0.524412 0.353659