Ensembl ID ENSG00000082515 Gene ID 29093 Accession 14480
Gene Symbol MRPL22 Alias L22mt;uL22m;RPML25;HSPC158;MRP-L22;MRP-L25 Full Name mitochondrial ribosomal protein L22
Position 5 : 154941073 - 154969411 Length 28339 bases Strand Plus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000082515 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000082515 MRPL22 0.48 2.09e-13 KIRC
ENSG00000082515 MRPL22 0.46 3.32e-20 BRCA
ENSG00000082515 MRPL22 0.93 3.62e-21 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000082515 MRPL22 SARC 0.011 high
ENSG00000082515 MRPL22 UVM 0.00026 high
ENSG00000082515 MRPL22 THCA 0.031 low
ENSG00000082515 MRPL22 ACC 0.0094 low
ENSG00000082515 MRPL22 HNSC 0.038 high
ENSG00000082515 MRPL22 KICH 0.013 high
ENSG00000082515 MRPL22 LUAD 0.0053 high
ENSG00000082515 MRPL22 THYM 0.048 low
ENSG00000082515 MRPL22 COAD 0.021 low
ENSG00000082515 MRPL22 UCS 0.039 high
ENSG00000082515 MRPL22 ESCA 0.0011 high
ENSG00000082515 MRPL22 OV 0.0027 low
ENSG00000082515 MRPL22 BLCA 0.029 low
ENSG00000082515 MRPL22 LAML 0.019 low
ENSG00000082515 MRPL22 GBM 0.032 high
ENSG00000082515 MRPL22 SKCM 0.0027 low
ENSG00000082515 MRPL22 CESC 0.0086 low
ENSG00000082515 MRPL22 LIHC 0.016 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000082515 MRPL22 LAML Del 6.035265 0.088426 0.803426 0.083770
ENSG00000082515 MRPL22 LGG Del 5.405577 0.077664 0.443635 0.115010
ENSG00000082515 MRPL22 SKCM Del 5.077094 0.123015 0.497388 0.343324
ENSG00000082515 MRPL22 KIRC Amp 50.764756 0.290896 0.544704 0.607955