Ensembl ID ENSG00000079246 Gene ID 7520 Accession 12833
Gene Symbol XRCC5 Alias KU80;KUB2;Ku86;NFIV;KARP1;KARP-1 Full Name X-ray repair cross complementing 5
Position 2 : 216107464 - 216206303 Length 98840 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

ENSG00000079246 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000079246 XRCC5 0.27 1.16e-13 BRCA
ENSG00000079246 XRCC5 -0.6 6.35e-12 KICH
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000079246 XRCC5 Cancer 10485901
ENSG00000079246 XRCC5 cancer 10761921
ENSG00000079246 XRCC5 cancer 10805721
ENSG00000079246 XRCC5 tumor 10806304
ENSG00000079246 XRCC5 breast cancer 10823943
ENSG00000079246 XRCC5 Tumor 11086072
ENSG00000079246 XRCC5 tumours 11104569
ENSG00000079246 XRCC5 tumor 11245607
ENSG00000079246 XRCC5 tumors 11314007
ENSG00000079246 XRCC5 colon cancer 11731412
ENSG00000079246 XRCC5 tumor 11781113
ENSG00000079246 XRCC5 colon cancer 11792868
ENSG00000079246 XRCC5 tumor 11882358
ENSG00000079246 XRCC5 tumors 11950917
ENSG00000079246 XRCC5 tumours 12017286
ENSG00000079246 XRCC5 AML 12168870
ENSG00000079246 XRCC5 tumors 12186839
ENSG00000079246 XRCC5 tumor 12216085
ENSG00000079246 XRCC5 gastric cancer 12324457
ENSG00000079246 XRCC5 tumor 12384553
ENSG00000079246 XRCC5 cancer 12388662
ENSG00000079246 XRCC5 neuroectodermal tumor 12403924
ENSG00000079246 XRCC5 liver cancer 12460917
ENSG00000079246 XRCC5 tumors 12658736
ENSG00000079246 XRCC5 cancer 12698192
ENSG00000079246 XRCC5 breast cancer 12750264
ENSG00000079246 XRCC5 cervical cancer 12902903
ENSG00000079246 XRCC5 tumours 15162024
ENSG00000079246 XRCC5 tumors 15175261
ENSG00000079246 XRCC5 Tumor 15254745
ENSG00000079246 XRCC5 tumor 15470482
ENSG00000079246 XRCC5 cancer 15492246
ENSG00000079246 XRCC5 tumor 15545322
ENSG00000079246 XRCC5 cancer 15827325
ENSG00000079246 XRCC5 tumor 15876251
ENSG00000079246 XRCC5 tumor 15966178
ENSG00000079246 XRCC5 cancer 16137195
ENSG00000079246 XRCC5 breast cancer 16177181
ENSG00000079246 XRCC5 prostate cancer 16273218
ENSG00000079246 XRCC5 Tumors 16425368
ENSG00000079246 XRCC5 cancers 16446442
ENSG00000079246 XRCC5 cancer 16472552
ENSG00000079246 XRCC5 prostate cancer 16490787
ENSG00000079246 XRCC5 non-melanoma skin cancer 16497868
ENSG00000079246 XRCC5 colorectal cancer 16533773
ENSG00000079246 XRCC5 colorectal tumors 16564919
ENSG00000079246 XRCC5 tumours 16685270
ENSG00000079246 XRCC5 cancer 16751807
ENSG00000079246 XRCC5 tumours 16827151
ENSG00000079246 XRCC5 tumor 16865228
ENSG00000079246 XRCC5 gastric cancer 17031478
ENSG00000079246 XRCC5 tumor 17089123
ENSG00000079246 XRCC5 cancer 17143500
ENSG00000079246 XRCC5 non-small cell lung cancer 17289874
ENSG00000079246 XRCC5 tumor 17355786
ENSG00000079246 XRCC5 cancer 17487369
ENSG00000079246 XRCC5 prostate cancer 17545612
ENSG00000079246 XRCC5 cervical cancer 17626748
ENSG00000079246 XRCC5 tumor 17653096
ENSG00000079246 XRCC5 cancer 17875923
ENSG00000079246 XRCC5 bladder cancer 17904587
ENSG00000079246 XRCC5 cancer 17942417
ENSG00000079246 XRCC5 cancer 17982634
ENSG00000079246 XRCC5 esophageal tumors 18403903
ENSG00000079246 XRCC5 tumor 18415044
ENSG00000079246 XRCC5 tumor 18457328
ENSG00000079246 XRCC5 tumor 18546291
ENSG00000079246 XRCC5 tumor 18571811
ENSG00000079246 XRCC5 HNSCC 18768166
ENSG00000079246 XRCC5 tumor 18772145
ENSG00000079246 XRCC5 cancer 18941635
ENSG00000079246 XRCC5 tumors 19010925
ENSG00000079246 XRCC5 tumor 19177010
ENSG00000079246 XRCC5 lung cancer 19192406
ENSG00000079246 XRCC5 oral cancer 19217823
ENSG00000079246 XRCC5 cancer 19330025
ENSG00000079246 XRCC5 cancer 19372586
ENSG00000079246 XRCC5 bladder cancer 19414375
ENSG00000079246 XRCC5 colorectal cancer 19528488
ENSG00000079246 XRCC5 tumor 19597334
ENSG00000079246 XRCC5 cancer 19652854
ENSG00000079246 XRCC5 tumours 19672258
ENSG00000079246 XRCC5 breast cancer 20044645
ENSG00000079246 XRCC5 ovarian cancer 20386703
ENSG00000079246 XRCC5 colon cancer 20536451
ENSG00000079246 XRCC5 cancer 20567092
ENSG00000079246 XRCC5 colon cancer 20689513
ENSG00000079246 XRCC5 thyroid cancer 20811692
ENSG00000079246 XRCC5 non-small cell lung cancer 21118646
ENSG00000079246 XRCC5 breast cancer 21137076
ENSG00000079246 XRCC5 cancer 21304054
ENSG00000079246 XRCC5 head and neck cancer 21349997
ENSG00000079246 XRCC5 cancer 21469750
ENSG00000079246 XRCC5 cancers 21521024
ENSG00000079246 XRCC5 gastric cancer 21547134
ENSG00000079246 XRCC5 cancer 21573502
ENSG00000079246 XRCC5 lung cancers 21663524
ENSG00000079246 XRCC5 head and neck cancer 21877955
ENSG00000079246 XRCC5 digestive system cancers 22224172
ENSG00000079246 XRCC5 tumor 22226916
ENSG00000079246 XRCC5 tumors 22348039
ENSG00000079246 XRCC5 colon cancers 22494821
ENSG00000079246 XRCC5 prostate cancer 22518120
ENSG00000079246 XRCC5 tumor 22554520
ENSG00000079246 XRCC5 tumor 22921042
ENSG00000079246 XRCC5 breast cancer 23098447
ENSG00000079246 XRCC5 tumor 23181744
ENSG00000079246 XRCC5 oral cancer 23437280
ENSG00000079246 XRCC5 cancer 23621240
ENSG00000079246 XRCC5 cancer 23663450
ENSG00000079246 XRCC5 oral cancer 23720673
ENSG00000079246 XRCC5 liver cancer 23788213
ENSG00000079246 XRCC5 tumor 23788963
ENSG00000079246 XRCC5 breast cancer 23868020
ENSG00000079246 XRCC5 cancer 23928100
ENSG00000079246 XRCC5 bladder cancer 23932191
ENSG00000079246 XRCC5 colorectal tumors 23937791
ENSG00000079246 XRCC5 tumors 23960188
ENSG00000079246 XRCC5 cancers 23982877
ENSG00000079246 XRCC5 tumors 24044516
ENSG00000079246 XRCC5 tumors 24271118
ENSG00000079246 XRCC5 tumor 24478815
ENSG00000079246 XRCC5 breast cancer 24615008
ENSG00000079246 XRCC5 cancer 24740260
ENSG00000079246 XRCC5 lung cancer 24744142
ENSG00000079246 XRCC5 tumors 24796461
ENSG00000079246 XRCC5 cancer 24811221
ENSG00000079246 XRCC5 liver tumor 24888377
ENSG00000079246 XRCC5 prostate cancer 24982817
ENSG00000079246 XRCC5 cancer 25277244
ENSG00000079246 XRCC5 gastric cancer 25527410
ENSG00000079246 XRCC5 non-small cell lung cancer 25596743
ENSG00000079246 XRCC5 tumor 25711486
ENSG00000079246 XRCC5 cancer 25742469
ENSG00000079246 XRCC5 tumor 25758053
ENSG00000079246 XRCC5 tumor 25797267
ENSG00000079246 XRCC5 cancer 25818292
ENSG00000079246 XRCC5 tumor 25860939
ENSG00000079246 XRCC5 prostate cancer 25937401
ENSG00000079246 XRCC5 cancer 26059197
ENSG00000079246 XRCC5 colorectal cancer 26108778
ENSG00000079246 XRCC5 HNSCC 26245169
ENSG00000079246 XRCC5 cancer 26337656
ENSG00000079246 XRCC5 tumors 26359349
ENSG00000079246 XRCC5 breast cancers 26459098
ENSG00000079246 XRCC5 cancer 26492073
ENSG00000079246 XRCC5 head and neck cancer 26713771
ENSG00000079246 XRCC5 malignant tumors 26722230
ENSG00000079246 XRCC5 uterine cervical cancer 26867665
ENSG00000079246 XRCC5 Cancer 26870890
ENSG00000079246 XRCC5 lung cancer 26918347
ENSG00000079246 XRCC5 Breast Cancer 27148484
ENSG00000079246 XRCC5 liver cancer 27278244
ENSG00000079246 XRCC5 tumor 27338590
ENSG00000079246 XRCC5 tumor 27385978
ENSG00000079246 XRCC5 Tumor 27593107
ENSG00000079246 XRCC5 tumor 27685632
ENSG00000079246 XRCC5 prostate cancer 27721405
ENSG00000079246 XRCC5 cancer 27852033
ENSG00000079246 XRCC5 tumors 28008145
ENSG00000079246 XRCC5 colon cancer 28035050
ENSG00000079246 XRCC5 Rectal Cancer 28068245
ENSG00000079246 XRCC5 breast cancer 28123543
ENSG00000079246 XRCC5 cervical cancer 28131528
ENSG00000079246 XRCC5 breast cancers 28254786
ENSG00000079246 XRCC5 lung cancer 28399858
ENSG00000079246 XRCC5 tumor 28684677
ENSG00000079246 XRCC5 prostate cancer 28697756
ENSG00000079246 XRCC5 breast cancer 28780472
ENSG00000079246 XRCC5 tumor 28881569
ENSG00000079246 XRCC5 tumor 29049411
ENSG00000079246 XRCC5 breast cancer 29133620
ENSG00000079246 XRCC5 prostate cancer 29179998
ENSG00000079246 XRCC5 cancers 29226073
ENSG00000079246 XRCC5 colon cancer 29277765
ENSG00000079246 XRCC5 cervical cancer 29375707
ENSG00000079246 XRCC5 tumor 29393484
ENSG00000079246 XRCC5 tumor 29532618
ENSG00000079246 XRCC5 cancer 29664240
ENSG00000079246 XRCC5 Breast cancer 29867559
ENSG00000079246 XRCC5 breast cancer 30090395
ENSG00000079246 XRCC5 cancer 30125607
ENSG00000079246 XRCC5 tumors 30217218
ENSG00000079246 XRCC5 tumor 30251028
ENSG00000079246 XRCC5 cancer 30271949
ENSG00000079246 XRCC5 thyroid cancer 30476230
ENSG00000079246 XRCC5 tumor 30765319
ENSG00000079246 XRCC5 oral cancer 30895012
ENSG00000079246 XRCC5 tumor 30968159
ENSG00000079246 XRCC5 tumor 31023624
ENSG00000079246 XRCC5 gastric cancer 31345372
ENSG00000079246 XRCC5 tumours 31394657
ENSG00000079246 XRCC5 tumor 31473257
ENSG00000079246 XRCC5 tumors 31578590
ENSG00000079246 XRCC5 tumors 31599408
ENSG00000079246 XRCC5 Tumor 31650563
ENSG00000079246 XRCC5 cancer 31816404
ENSG00000079246 XRCC5 breast cancer 31920325
ENSG00000079246 XRCC5 cancer 9542526
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000079246 XRCC5 PAAD 0.0064 high
ENSG00000079246 XRCC5 UCEC 0.0033 low
ENSG00000079246 XRCC5 THCA 0.042 low
ENSG00000079246 XRCC5 LGG 0.016 high
ENSG00000079246 XRCC5 HNSC 0.018 low
ENSG00000079246 XRCC5 READ 0.035 low
ENSG00000079246 XRCC5 KIRP 0.01 high
ENSG00000079246 XRCC5 KICH 0.0045 high
ENSG00000079246 XRCC5 LUAD 0.00055 high
ENSG00000079246 XRCC5 PCPG 0.012 high
ENSG00000079246 XRCC5 THYM 0.016 low
ENSG00000079246 XRCC5 DLBC 0.037 low
ENSG00000079246 XRCC5 PRAD 0.01 high
ENSG00000079246 XRCC5 TGCT 0.028 low
ENSG00000079246 XRCC5 GBM 0.003 low
ENSG00000079246 XRCC5 CESC 0.0083 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000079246 XRCC5 LUSC Del 16.007455 0.186925 0.402686 0.291417
ENSG00000079246 XRCC5 CESC Del 31.058486 0.327731 0.536958 0.386441
ENSG00000079246 XRCC5 KIRP Amp 1.259300 0.069152 0.554374 0.163194
ENSG00000079246 XRCC5 KIRP Del 1.676805 0.036840 0.608607 0.038194
ENSG00000079246 XRCC5 SARC Del 4.950103 0.215687 0.479496 0.357977
ENSG00000079246 XRCC5 ESCA Del 1.663897 0.123563 0.364049 0.250000
ENSG00000079246 XRCC5 HNSC Del 20.304355 0.173183 0.386868 0.279693
ENSG00000079246 XRCC5 BLCA Del 21.137714 0.256599 0.432227 0.460784
ENSG00000079246 XRCC5 KIRC Del 8.429551 0.060899 0.534563 0.083333