Ensembl ID ENSG00000078328 Gene ID 54715 Accession 18222
Gene Symbol RBFOX1 Alias 2BP1;FOX1;A2BP1;FOX-1;HRNBP1 Full Name RNA binding fox-1 homolog 1
Position 16 : 5239802 - 7713340 Length 2473539 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

ENSG00000078328 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000078328 RBFOX1 -2.3 2.28e-15 KIRC
ENSG00000078328 RBFOX1 -3.6 1.19e-15 HNSC
ENSG00000078328 RBFOX1 -1.7 8.83e-12 PRAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000078328 RBFOX1 gastric cancer 20331625
ENSG00000078328 RBFOX1 cystic tumors 20724451
ENSG00000078328 RBFOX1 colorectal cancers 23286373
ENSG00000078328 RBFOX1 tumor 23805207
ENSG00000078328 RBFOX1 tumor 23830731
ENSG00000078328 RBFOX1 GBM 23918370
ENSG00000078328 RBFOX1 tumor 24406431
ENSG00000078328 RBFOX1 cancers 24651849
ENSG00000078328 RBFOX1 tumor 24937453
ENSG00000078328 RBFOX1 Cancer 25575132
ENSG00000078328 RBFOX1 cancer 26208496
ENSG00000078328 RBFOX1 colon cancer 26222184
ENSG00000078328 RBFOX1 tumor 30059005
ENSG00000078328 RBFOX1 tumor 30429477
ENSG00000078328 RBFOX1 tumor 30984543
ENSG00000078328 RBFOX1 lung cancer 31512508
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000078328 RBFOX1 MESO 0.00061 low
ENSG00000078328 RBFOX1 CHOL 0.00028 high
ENSG00000078328 RBFOX1 LGG 8e-04 low
ENSG00000078328 RBFOX1 LUSC 0.0012 low
ENSG00000078328 RBFOX1 HNSC 0.0049 high
ENSG00000078328 RBFOX1 KIRP 0.045 low
ENSG00000078328 RBFOX1 LUAD 0.0068 low
ENSG00000078328 RBFOX1 PCPG 0.0073 low
ENSG00000078328 RBFOX1 BRCA 0.003 high
ENSG00000078328 RBFOX1 UCS 0.019 high
ENSG00000078328 RBFOX1 KIRC 0.00025 high
ENSG00000078328 RBFOX1 LIHC 0.017 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000078328 RBFOX1 LUSC Del 2.252898 0.086007 0.349852 0.351297
ENSG00000078328 RBFOX1 ACC Del 1.947196 0.147962 0.317247 0.088889
ENSG00000078328 RBFOX1 READ Del 35.598588 0.516391 0.346741 0.072727
ENSG00000078328 RBFOX1 COAD Del 122.540899 0.529322 0.349353 0.093126
ENSG00000078328 RBFOX1 SKCM Del 3.745523 0.108560 0.342658 0.168937
ENSG00000078328 RBFOX1 BLCA Del 6.218032 0.145945 0.390737 0.406863
ENSG00000078328 RBFOX1 STAD Del 5.605089 0.113420 0.359524 0.235828
ENSG00000078328 RBFOX1 MESO Del 11.501438 0.428082 0.327982 0.068966