Ensembl ID ENSG00000075151 Gene ID 8672 Accession 3298
Gene Symbol EIF4G3 Alias eIF4G3;eIF4GII;eIF-4G3 Full Name eukaryotic translation initiation factor 4 gamma 3
Position 1 : 20806292 - 21177285 Length 370994 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]

ENSG00000075151 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000075151 EIF4G3 -0.3 1.35e-11 KIRC
ENSG00000075151 EIF4G3 0.51 6.15e-14 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000075151 EIF4G3 tumor 14610163
ENSG00000075151 EIF4G3 tumor 24497838
ENSG00000075151 EIF4G3 tumor 29996881
ENSG00000075151 EIF4G3 gastric cancer 31257089
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000075151 EIF4G3 STAD 0.0095 low
ENSG00000075151 EIF4G3 UVM 0.0019 high
ENSG00000075151 EIF4G3 PAAD 0.034 high
ENSG00000075151 EIF4G3 ACC 0.011 high
ENSG00000075151 EIF4G3 LGG 0.0015 high
ENSG00000075151 EIF4G3 KICH 0.002 high
ENSG00000075151 EIF4G3 THYM 0.0021 high
ENSG00000075151 EIF4G3 COAD 0.013 low
ENSG00000075151 EIF4G3 UCS 0.043 high
ENSG00000075151 EIF4G3 ESCA 0.0096 low
ENSG00000075151 EIF4G3 DLBC 0.0065 high
ENSG00000075151 EIF4G3 TGCT 0.0027 low
ENSG00000075151 EIF4G3 LAML 0.034 low
ENSG00000075151 EIF4G3 GBM 0.05 high
ENSG00000075151 EIF4G3 SKCM 0.037 low
ENSG00000075151 EIF4G3 CESC 0.049 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000075151 EIF4G3 CHOL Del 22.011712 1.109716 0.699731 0.805556
ENSG00000075151 EIF4G3 LUSC Del 6.065588 0.122311 0.387902 0.455090
ENSG00000075151 EIF4G3 LUAD Del 1.195899 0.058119 0.292318 0.236434
ENSG00000075151 EIF4G3 CESC Del 1.639951 0.085144 0.420302 0.122034
ENSG00000075151 EIF4G3 KIRP Del 6.594500 0.077440 0.585567 0.180556
ENSG00000075151 EIF4G3 READ Del 8.741826 0.217186 0.450436 0.454545
ENSG00000075151 EIF4G3 COAD Del 18.013619 0.156756 0.454534 0.354767
ENSG00000075151 EIF4G3 UCS Del 0.873063 0.214597 0.480396 0.303571
ENSG00000075151 EIF4G3 SARC Del 0.725980 0.120903 0.638194 0.159533
ENSG00000075151 EIF4G3 GBM Del 5.148209 0.093630 0.531102 0.097054
ENSG00000075151 EIF4G3 PAAD Del 2.948902 0.085318 0.352488 0.326087
ENSG00000075151 EIF4G3 ESCA Del 0.871108 0.101793 0.340467 0.364130
ENSG00000075151 EIF4G3 SKCM Del 2.232616 0.089680 0.453725 0.193460
ENSG00000075151 EIF4G3 HNSC Del 2.749009 0.075080 0.380776 0.174330
ENSG00000075151 EIF4G3 LIHC Del 16.875877 0.215652 0.541988 0.381081
ENSG00000075151 EIF4G3 PCPG Del 2.621103 0.096236 0.676520 0.629630
ENSG00000075151 EIF4G3 TGCT Del 0.739401 0.056298 0.349111 0.200000
ENSG00000075151 EIF4G3 BLCA Del 1.078463 0.083852 0.328410 0.193627
ENSG00000075151 EIF4G3 BRCA Del 36.511212 0.194075 0.432678 0.409259
ENSG00000075151 EIF4G3 STAD Del 6.391761 0.120049 0.366757 0.260771
ENSG00000075151 EIF4G3 UCEC Del 12.026023 0.131163 0.512884 0.148423
ENSG00000075151 EIF4G3 MESO Del 4.213546 0.245152 0.533620 0.333333
ENSG00000075151 EIF4G3 KIRC Del 6.474970 0.052697 0.418393 0.181818
ENSG00000075151 EIF4G3 UVM Del 2.306078 0.116385 0.824497 0.312500
ENSG00000075151 EIF4G3 OV Del 27.389413 0.433247 0.561186 0.431779