Ensembl ID ENSG00000074800 Gene ID 2023 Accession 3350
Gene Symbol ENO1 Alias NNE;PPH;MPB1;ENO1L1;ENO1-IT1;HEL-S-17 Full Name enolase 1
Position 1 : 8861000 - 8879190 Length 18191 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]

ENSG00000074800 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000074800 ENO1 0.59 1.47e-12 KIRC
ENSG00000074800 ENO1 0.77 1.17e-12 COAD
ENSG00000074800 ENO1 -1.2 1.04e-18 KICH
ENSG00000074800 ENO1 1.26 1.82e-38 LUSC
ENSG00000074800 ENO1 1.82 9.81e-50 UCEC
ENSG00000074800 ENO1 1.18 6.27e-35 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000074800 ENO1 tumors 10197443
ENSG00000074800 ENO1 tumor 10802057
ENSG00000074800 ENO1 tumour 12922171
ENSG00000074800 ENO1 pituitary tumors 14709840
ENSG00000074800 ENO1 lung cancer 15378762
ENSG00000074800 ENO1 cancers 15533718
ENSG00000074800 ENO1 tumors 15604267
ENSG00000074800 ENO1 lung cancer 15627843
ENSG00000074800 ENO1 tumor 15800975
ENSG00000074800 ENO1 cancer-associated retinopathy 15808190
ENSG00000074800 ENO1 cancer 15860281
ENSG00000074800 ENO1 lung cancer 15966408
ENSG00000074800 ENO1 breast tumors 16048908
ENSG00000074800 ENO1 tumor 16051329
ENSG00000074800 ENO1 tumour 16359544
ENSG00000074800 ENO1 tumor 16714762
ENSG00000074800 ENO1 liver cancer 16820872
ENSG00000074800 ENO1 tumor 17020980
ENSG00000074800 ENO1 breast cancer 17051647
ENSG00000074800 ENO1 cancer 17094902
ENSG00000074800 ENO1 cancer-associated retinopathy 17235687
ENSG00000074800 ENO1 cancer 17366473
ENSG00000074800 ENO1 cancer 17506794
ENSG00000074800 ENO1 pancreatic cancer 17982661
ENSG00000074800 ENO1 breast tumors 17996735
ENSG00000074800 ENO1 tumors 18401453
ENSG00000074800 ENO1 metastatic cancer 18560153
ENSG00000074800 ENO1 tumor 18564415
ENSG00000074800 ENO1 colon cancer 18691435
ENSG00000074800 ENO1 cancer 19407367
ENSG00000074800 ENO1 pancreatic cancer 19425054
ENSG00000074800 ENO1 cancer 19523545
ENSG00000074800 ENO1 tumor 19771267
ENSG00000074800 ENO1 tumor 20021653
ENSG00000074800 ENO1 cancer 20023747
ENSG00000074800 ENO1 cancer 20395242
ENSG00000074800 ENO1 breast cancer 20406904
ENSG00000074800 ENO1 tumor 20412594
ENSG00000074800 ENO1 head and neck cancer 20435467
ENSG00000074800 ENO1 small cell lung cancer 20557064
ENSG00000074800 ENO1 tumor 20621659
ENSG00000074800 ENO1 tumor 20655599
ENSG00000074800 ENO1 tumors 20721957
ENSG00000074800 ENO1 cancer 20849415
ENSG00000074800 ENO1 thyroid cancer 20873772
ENSG00000074800 ENO1 tumor 20886042
ENSG00000074800 ENO1 tumors 20975849
ENSG00000074800 ENO1 tumor 21062455
ENSG00000074800 ENO1 tumor 21136681
ENSG00000074800 ENO1 non-small cell lung cancer 21159241
ENSG00000074800 ENO1 tumor 21185818
ENSG00000074800 ENO1 DLBCL 21323512
ENSG00000074800 ENO1 pancreatic cancer 21472101
ENSG00000074800 ENO1 tumors 21503584
ENSG00000074800 ENO1 gastric cancer 21751384
ENSG00000074800 ENO1 ovarian cancer 21754983
ENSG00000074800 ENO1 tumor 21835052
ENSG00000074800 ENO1 stomach cancer 21860611
ENSG00000074800 ENO1 nasopharyngeal cancer 21950004
ENSG00000074800 ENO1 breast cancer 22014164
ENSG00000074800 ENO1 tumor 22110952
ENSG00000074800 ENO1 malignant brain tumor 22192797
ENSG00000074800 ENO1 cancer-associated retinopathy 22415770
ENSG00000074800 ENO1 tumor 22552009
ENSG00000074800 ENO1 prostate cancer 22734040
ENSG00000074800 ENO1 gastric tumors 22860099
ENSG00000074800 ENO1 GBM 22895339
ENSG00000074800 ENO1 cancer 22997098
ENSG00000074800 ENO1 cancer 23140188
ENSG00000074800 ENO1 pancreatic cancer 23333712
ENSG00000074800 ENO1 breast cancer 23381546
ENSG00000074800 ENO1 metastatic tumors 23504277
ENSG00000074800 ENO1 cancers 23594883
ENSG00000074800 ENO1 cancer 23640603
ENSG00000074800 ENO1 cancer 23845056
ENSG00000074800 ENO1 tumor 23894455
ENSG00000074800 ENO1 tumor 23894698
ENSG00000074800 ENO1 tumor 23902561
ENSG00000074800 ENO1 tumor 23952686
ENSG00000074800 ENO1 tumour 24099319
ENSG00000074800 ENO1 Neuroendocrine Tumors 24310147
ENSG00000074800 ENO1 tumor 24338489
ENSG00000074800 ENO1 tumor 24338690
ENSG00000074800 ENO1 prostate cancer 24391718
ENSG00000074800 ENO1 cancer 24450150
ENSG00000074800 ENO1 cancer 24504108
ENSG00000074800 ENO1 pancreatic cancer 24556680
ENSG00000074800 ENO1 DLBCL 24625895
ENSG00000074800 ENO1 tumor 24650096
ENSG00000074800 ENO1 tumor 24684412
ENSG00000074800 ENO1 cancer 24841372
ENSG00000074800 ENO1 lung cancer 24984566
ENSG00000074800 ENO1 tumor 25019393
ENSG00000074800 ENO1 pituitary tumor 25188299
ENSG00000074800 ENO1 cancer 25243088
ENSG00000074800 ENO1 colonic cancer 25413056
ENSG00000074800 ENO1 tumor 25643152
ENSG00000074800 ENO1 gastric cancer 25784992
ENSG00000074800 ENO1 tumor 25860938
ENSG00000074800 ENO1 non-small cell lung cancer 25887760
ENSG00000074800 ENO1 tumors 25951350
ENSG00000074800 ENO1 tumor 25975782
ENSG00000074800 ENO1 tumor 26024773
ENSG00000074800 ENO1 tumor 26037892
ENSG00000074800 ENO1 pancreatic cancer 26096821
ENSG00000074800 ENO1 colorectal cancer 26097998
ENSG00000074800 ENO1 breast cancer 26144282
ENSG00000074800 ENO1 lung cancer 26185761
ENSG00000074800 ENO1 tumor 26266422
ENSG00000074800 ENO1 cancer 26279629
ENSG00000074800 ENO1 tumour 26401126
ENSG00000074800 ENO1 tumors 26506425
ENSG00000074800 ENO1 lung cancer 26551021
ENSG00000074800 ENO1 tumor 26701732
ENSG00000074800 ENO1 cancer 26734996
ENSG00000074800 ENO1 lung cancer 26805845
ENSG00000074800 ENO1 cancer 26840568
ENSG00000074800 ENO1 cancer 26882120
ENSG00000074800 ENO1 tumor 26918942
ENSG00000074800 ENO1 bladder cancer 27034531
ENSG00000074800 ENO1 tumor 27051584
ENSG00000074800 ENO1 tumor 27110560
ENSG00000074800 ENO1 tumor 27210467
ENSG00000074800 ENO1 tumor 27308346
ENSG00000074800 ENO1 tumor 27467915
ENSG00000074800 ENO1 tumour 27605433
ENSG00000074800 ENO1 tumor 27624754
ENSG00000074800 ENO1 lung cancer 27684953
ENSG00000074800 ENO1 GBM 27686855
ENSG00000074800 ENO1 cancers 27723749
ENSG00000074800 ENO1 tumors 27741516
ENSG00000074800 ENO1 tumor 27767175
ENSG00000074800 ENO1 tumor 27814656
ENSG00000074800 ENO1 cancer 27878450
ENSG00000074800 ENO1 tumor 27906678
ENSG00000074800 ENO1 cancer 27996156
ENSG00000074800 ENO1 cancer 28030597
ENSG00000074800 ENO1 pancreatic cancer 28086938
ENSG00000074800 ENO1 cancer 28415822
ENSG00000074800 ENO1 non-small cell lung cancer 28456790
ENSG00000074800 ENO1 tumor 28525970
ENSG00000074800 ENO1 gastric cancer 28548950
ENSG00000074800 ENO1 cancer 28630480
ENSG00000074800 ENO1 tumors 28656302
ENSG00000074800 ENO1 tumors 28659184
ENSG00000074800 ENO1 cervical cancer 28670312
ENSG00000074800 ENO1 cancer 28716111
ENSG00000074800 ENO1 tumor 28730771
ENSG00000074800 ENO1 Pancreatic Cancer 28824297
ENSG00000074800 ENO1 cancer 29032577
ENSG00000074800 ENO1 tumor 29285267
ENSG00000074800 ENO1 AML 29286103
ENSG00000074800 ENO1 cancers 29286311
ENSG00000074800 ENO1 tumor 29308319
ENSG00000074800 ENO1 tumor 29462900
ENSG00000074800 ENO1 tumor 29483925
ENSG00000074800 ENO1 tumor 29497031
ENSG00000074800 ENO1 lung cancer 29538538
ENSG00000074800 ENO1 cancer 29545914
ENSG00000074800 ENO1 tumor 29560103
ENSG00000074800 ENO1 cancer 29767008
ENSG00000074800 ENO1 cancer 29882813
ENSG00000074800 ENO1 Cancer 29956637
ENSG00000074800 ENO1 Gastric Cancer 29986635
ENSG00000074800 ENO1 tumour 29997113
ENSG00000074800 ENO1 cancer 30242159
ENSG00000074800 ENO1 tumours 3029273
ENSG00000074800 ENO1 cancer 30301274
ENSG00000074800 ENO1 lung cancer 3036329
ENSG00000074800 ENO1 tumor 30478344
ENSG00000074800 ENO1 tumour 30500420
ENSG00000074800 ENO1 cancer 30510459
ENSG00000074800 ENO1 cancer 30518090
ENSG00000074800 ENO1 cancer 30518748
ENSG00000074800 ENO1 cancers 30532594
ENSG00000074800 ENO1 cancer 30538002
ENSG00000074800 ENO1 tumor 30541900
ENSG00000074800 ENO1 cancer 30563992
ENSG00000074800 ENO1 gastric cancer 30582908
ENSG00000074800 ENO1 cancer 30660590
ENSG00000074800 ENO1 gastric cancer 30678426
ENSG00000074800 ENO1 tumor 30683669
ENSG00000074800 ENO1 gastric cancer 30881118
ENSG00000074800 ENO1 pancreatic cancer 30911653
ENSG00000074800 ENO1 gastric cancer 30930989
ENSG00000074800 ENO1 tumor 30936746
ENSG00000074800 ENO1 cancer 30950146
ENSG00000074800 ENO1 tumors 30967137
ENSG00000074800 ENO1 gastric cancer 31218757
ENSG00000074800 ENO1 cancers 31324042
ENSG00000074800 ENO1 breast cancer 31329371
ENSG00000074800 ENO1 liver cancer 31357775
ENSG00000074800 ENO1 cancer 31394609
ENSG00000074800 ENO1 pancreatic cancer 31396350
ENSG00000074800 ENO1 breast cancer 31416219
ENSG00000074800 ENO1 breast cancer 31428694
ENSG00000074800 ENO1 cancers 31431517
ENSG00000074800 ENO1 GBM 31450721
ENSG00000074800 ENO1 cancer 31511554
ENSG00000074800 ENO1 lung cancer 31514848
ENSG00000074800 ENO1 cancer 31646071
ENSG00000074800 ENO1 tumor 31709724
ENSG00000074800 ENO1 tumor 31767835
ENSG00000074800 ENO1 gastric cancer 31889896
ENSG00000074800 ENO1 breast cancer 31925137
ENSG00000074800 ENO1 small-cell lung cancer 31957179
ENSG00000074800 ENO1 breast cancer 31957838
ENSG00000074800 ENO1 tumours 3652476
ENSG00000074800 ENO1 tumors 6315226
ENSG00000074800 ENO1 tumor 6327451
ENSG00000074800 ENO1 cancer 8402458
ENSG00000074800 ENO1 tumors 8632173
ENSG00000074800 ENO1 breast cancer 8810346
ENSG00000074800 ENO1 tumors 9008332
ENSG00000074800 ENO1 breast cancer 9119380
ENSG00000074800 ENO1 tumor 9393757
ENSG00000074800 ENO1 breast cancer 9635833
ENSG00000074800 ENO1 tumor 9713999
ENSG00000074800 ENO1 tumor 9878089
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000074800 ENO1 SARC 0.0039 high
ENSG00000074800 ENO1 PAAD 0.0025 high
ENSG00000074800 ENO1 ACC 0.0039 high
ENSG00000074800 ENO1 LGG 0.00018 high
ENSG00000074800 ENO1 HNSC 0.019 high
ENSG00000074800 ENO1 KIRP 0.036 low
ENSG00000074800 ENO1 LUAD 0.00023 high
ENSG00000074800 ENO1 PCPG 0.042 low
ENSG00000074800 ENO1 THYM 0.01 low
ENSG00000074800 ENO1 BRCA 0.0082 high
ENSG00000074800 ENO1 UCS 0.012 high
ENSG00000074800 ENO1 ESCA 0.026 high
ENSG00000074800 ENO1 DLBC 0.029 low
ENSG00000074800 ENO1 KIRC 0.0025 low
ENSG00000074800 ENO1 BLCA 0.0055 high
ENSG00000074800 ENO1 GBM 0.00066 high
ENSG00000074800 ENO1 CESC 0.01 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000074800 ENO1 CHOL Del 21.728296 1.091672 0.701780 0.805556
ENSG00000074800 ENO1 LUSC Del 4.411864 0.107617 0.383926 0.437126
ENSG00000074800 ENO1 LUAD Del 1.335425 0.060007 0.300893 0.226744
ENSG00000074800 ENO1 LGG Del 2.607246 0.057615 0.699593 0.405458
ENSG00000074800 ENO1 CESC Del 2.878808 0.104228 0.440706 0.128814
ENSG00000074800 ENO1 KIRP Del 6.769681 0.079319 0.591922 0.184028
ENSG00000074800 ENO1 ACC Del 4.275032 0.234574 0.602444 0.422222
ENSG00000074800 ENO1 READ Del 7.999942 0.198814 0.457520 0.430303
ENSG00000074800 ENO1 COAD Del 14.959224 0.140432 0.451206 0.334812
ENSG00000074800 ENO1 UCS Del 1.493236 0.270662 0.510580 0.321429
ENSG00000074800 ENO1 SARC Del 4.891596 0.214845 0.672508 0.214008
ENSG00000074800 ENO1 GBM Del 44.472257 0.278449 0.642280 0.220104
ENSG00000074800 ENO1 PAAD Del 1.783676 0.067077 0.344285 0.304348
ENSG00000074800 ENO1 SKCM Del 4.719189 0.119180 0.465497 0.198910
ENSG00000074800 ENO1 HNSC Del 3.348108 0.080058 0.382105 0.178161
ENSG00000074800 ENO1 LIHC Del 29.147401 0.292023 0.572650 0.418919
ENSG00000074800 ENO1 PCPG Del 3.298901 0.106928 0.674647 0.635802
ENSG00000074800 ENO1 TGCT Del 2.882801 0.103213 0.377195 0.220000
ENSG00000074800 ENO1 BRCA Del 33.896633 0.187158 0.427805 0.406481
ENSG00000074800 ENO1 STAD Del 2.339860 0.082733 0.345182 0.226757
ENSG00000074800 ENO1 UCEC Del 8.592869 0.111479 0.513943 0.122449
ENSG00000074800 ENO1 MESO Del 5.083143 0.271285 0.533156 0.356322
ENSG00000074800 ENO1 KIRC Del 7.972279 0.059259 0.410877 0.193182
ENSG00000074800 ENO1 UVM Del 1.063142 0.074432 0.793729 0.300000
ENSG00000074800 ENO1 OV Del 15.380058 0.346859 0.554866 0.362694