Ensembl ID ENSG00000073792 Gene ID 10644 Accession 28867
Gene Symbol IGF2BP2 Alias IMP2;IMP-2;VICKZ2 Full Name insulin like growth factor 2 mRNA binding protein 2
Position 3 : 185643130 - 185825042 Length 181913 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]

ENSG00000073792 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000073792 IGF2BP2 2.35 7.81e-36 HNSC
ENSG00000073792 IGF2BP2 2.60 3.27e-41 LUSC
ENSG00000073792 IGF2BP2 2.27 1.51e-16 LIHC
ENSG00000073792 IGF2BP2 1.53 5.92e-15 STAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000073792 IGF2BP2 cancer 17534663
ENSG00000073792 IGF2BP2 cancer 19832977
ENSG00000073792 IGF2BP2 colorectal cancer 21172019
ENSG00000073792 IGF2BP2 soft tissue tumors 21414819
ENSG00000073792 IGF2BP2 GBM 22899010
ENSG00000073792 IGF2BP2 cancer 23069990
ENSG00000073792 IGF2BP2 HNSCC 23482325
ENSG00000073792 IGF2BP2 cancer 24468095
ENSG00000073792 IGF2BP2 tumor 24814803
ENSG00000073792 IGF2BP2 breast cancer 25661373
ENSG00000073792 IGF2BP2 Breast Cancer 25721883
ENSG00000073792 IGF2BP2 tumor 25741595
ENSG00000073792 IGF2BP2 gastric cancer 26115082
ENSG00000073792 IGF2BP2 tumor 26208975
ENSG00000073792 IGF2BP2 Cancer 26244988
ENSG00000073792 IGF2BP2 colorectal cancer 27153315
ENSG00000073792 IGF2BP2 Breast Cancer 27733218
ENSG00000073792 IGF2BP2 cancer 28753127
ENSG00000073792 IGF2BP2 tumor 28768706
ENSG00000073792 IGF2BP2 tumour 28901413
ENSG00000073792 IGF2BP2 breast cancer 29066719
ENSG00000073792 IGF2BP2 tumour 29089486
ENSG00000073792 IGF2BP2 gallbladder cancer 29163784
ENSG00000073792 IGF2BP2 non-small cell lung cancer 29510198
ENSG00000073792 IGF2BP2 tumor 29660014
ENSG00000073792 IGF2BP2 Cancer 29736175
ENSG00000073792 IGF2BP2 non-small-cell lung cancer 30214291
ENSG00000073792 IGF2BP2 tumors 30220054
ENSG00000073792 IGF2BP2 HNSCC 30243807
ENSG00000073792 IGF2BP2 colon cancer 30335892
ENSG00000073792 IGF2BP2 cancer 30335898
ENSG00000073792 IGF2BP2 cancers 30513526
ENSG00000073792 IGF2BP2 tumour 30513694
ENSG00000073792 IGF2BP2 tumor 30643453
ENSG00000073792 IGF2BP2 tumor 31230592
ENSG00000073792 IGF2BP2 Pancreatic Cancer 31261900
ENSG00000073792 IGF2BP2 tongue cancer 31310629
ENSG00000073792 IGF2BP2 tumor 31484926
ENSG00000073792 IGF2BP2 cancer 31548560
ENSG00000073792 IGF2BP2 pancreatic cancer 31612115
ENSG00000073792 IGF2BP2 tumor 31692433
ENSG00000073792 IGF2BP2 colorectal cancer 31791342
ENSG00000073792 IGF2BP2 pancreatic cancer 31804607
ENSG00000073792 IGF2BP2 pancreatic cancer 31852504
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000073792 IGF2BP2 colorectal adenocarcinoma sequence_alteration 2.46% (28/1138) 1 entry
ENSG00000073792 IGF2BP2 colon adenocarcinoma missense_variant 1.108% (8/722) 4 entries
ENSG00000073792 IGF2BP2 squamous cell lung carcinoma missense_variant 1.837% (14/762) 1 entry
ENSG00000073792 IGF2BP2 head and neck squamous cell carcinoma sequence_alteration 0.6349% (4/630) 1 entry
ENSG00000073792 IGF2BP2 esophageal adenocarcinoma missense_variant 10.48% (46/439) 2 entries
ENSG00000073792 IGF2BP2 breast ductal adenocarcinoma sequence_alteration 17.81% (104/584) 2 entries
ENSG00000073792 IGF2BP2 prostate adenocarcinoma sequence_alteration 5.089% (74/1454) 2 entries
ENSG00000073792 IGF2BP2 Gallbladder Adenocarcinoma sequence_alteration 3.448% (3/87) 1 entry
ENSG00000073792 IGF2BP2 esophageal squamous cell carcinoma missense_variant 1.185% (8/675) 2 entries
ENSG00000073792 IGF2BP2 colorectal adenocarcinoma frameshift_variant 2.46% (28/1138) 2 entries
ENSG00000073792 IGF2BP2 colorectal adenocarcinoma missense_variant 2.46% (28/1138) 3 entries
ENSG00000073792 IGF2BP2 hepatocellular carcinoma missense_variant 1.443% (13/901) 1 entry
ENSG00000073792 IGF2BP2 female breast carcinoma missense_variant 2.247% (6/267) 1 entry
ENSG00000073792 IGF2BP2 lung adenocarcinoma missense_variant 1.204% (14/1163) 4 entries
ENSG00000073792 IGF2BP2 colon adenocarcinoma sequence_alteration 1.108% (8/722) 2 entries
ENSG00000073792 IGF2BP2 brain glioblastoma sequence_alteration 0.324% (3/926) 2 entries
ENSG00000073792 IGF2BP2 central nervous system primitive neuroectodermal neoplasm missense_variant 2.928% (13/444) 1 entry
ENSG00000073792 IGF2BP2 skin melanoma sequence_alteration 0.9307% (9/967) 1 entry
ENSG00000073792 IGF2BP2 prostate carcinoma sequence_alteration 3.991% (17/426) 2 entries
ENSG00000073792 IGF2BP2 small cell lung carcinoma missense_variant 0.6289% (2/318) 2 entries
ENSG00000073792 IGF2BP2 esophageal squamous cell carcinoma sequence_alteration 1.185% (8/675) 1 entry
ENSG00000073792 IGF2BP2 skin melanoma missense_variant 0.9307% (9/967) 3 entries
ENSG00000073792 IGF2BP2 anaplastic astrocytoma sequence_alteration 2.273% (1/44) 1 entry
ENSG00000073792 IGF2BP2 melanoma sequence_alteration 1.98% (2/101) 1 entry
ENSG00000073792 IGF2BP2 primary peritoneal carcinoma (disease) frameshift_variant 100.0% (1/1) 1 entry
ENSG00000073792 IGF2BP2 non-small cell lung carcinoma missense_variant 1.887% (1/53) 1 entry
ENSG00000073792 IGF2BP2 nasopharyngeal squamous cell carcinoma sequence_alteration 0.5988% (1/167) 1 entry
ENSG00000073792 IGF2BP2 melanoma missense_variant 1.98% (2/101) 1 entry
ENSG00000073792 IGF2BP2 Merkel cell skin cancer missense_variant 3.333% (1/30) 1 entry
ENSG00000073792 IGF2BP2 colon adenocarcinoma frameshift_variant 1.108% (8/722) 1 entry
ENSG00000073792 IGF2BP2 clear cell renal carcinoma sequence_alteration 0.155% (2/1290) 1 entry
ENSG00000073792 IGF2BP2 Gallbladder Adenocarcinoma missense_variant 3.448% (3/87) 1 entry
ENSG00000073792 IGF2BP2 ependymoma sequence_alteration 2.174% (1/46) 1 entry
ENSG00000073792 IGF2BP2 large cell lung carcinoma missense_variant 5.556% (1/18) 1 entry
ENSG00000073792 IGF2BP2 esophageal squamous cell carcinoma stop_gained 1.185% (8/675) 1 entry
ENSG00000073792 IGF2BP2 basal cell carcinoma sequence_alteration 1.724% (1/58) 1 entry
ENSG00000073792 IGF2BP2 astrocytoma sequence_alteration 50.0% (1/2) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000073792 IGF2BP2 CHOL 0.023 high
ENSG00000073792 IGF2BP2 UVM 0.00073 low
ENSG00000073792 IGF2BP2 PAAD 0.00011 high
ENSG00000073792 IGF2BP2 THCA 0.00057 low
ENSG00000073792 IGF2BP2 LUSC 0.05 low
ENSG00000073792 IGF2BP2 READ 0.025 high
ENSG00000073792 IGF2BP2 KIRP 0.0083 high
ENSG00000073792 IGF2BP2 LUAD 0.00041 high
ENSG00000073792 IGF2BP2 THYM 0.019 low
ENSG00000073792 IGF2BP2 COAD 0.0081 high
ENSG00000073792 IGF2BP2 UCS 0.014 low
ENSG00000073792 IGF2BP2 OV 0.035 low
ENSG00000073792 IGF2BP2 DLBC 0.0021 low
ENSG00000073792 IGF2BP2 BLCA 0.00015 high
ENSG00000073792 IGF2BP2 LAML 0.0028 high
ENSG00000073792 IGF2BP2 LIHC 0.0014 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000073792 IGF2BP2 LUSC Amp 145.927604 1.732909 1.299000 0.888224
ENSG00000073792 IGF2BP2 LUAD Amp 1.686858 0.142502 0.443692 0.275194
ENSG00000073792 IGF2BP2 CESC Amp 26.491025 0.651765 1.066615 0.752542
ENSG00000073792 IGF2BP2 UCS Amp 3.100062 0.843992 1.039257 0.607143
ENSG00000073792 IGF2BP2 GBM Amp 5.928884 0.145790 0.595532 0.168111
ENSG00000073792 IGF2BP2 ESCA Amp 10.909210 0.698116 0.867857 0.646739
ENSG00000073792 IGF2BP2 HNSC Amp 42.547947 0.629148 0.801507 0.718391
ENSG00000073792 IGF2BP2 PCPG Del 2.602850 0.095567 0.639373 0.580247
ENSG00000073792 IGF2BP2 TGCT Amp 3.763628 0.245404 0.566998 0.320000
ENSG00000073792 IGF2BP2 BLCA Amp 1.131626 0.180296 0.492112 0.534314
ENSG00000073792 IGF2BP2 BRCA Amp 4.780488 0.209076 0.552549 0.295370
ENSG00000073792 IGF2BP2 STAD Amp 5.608871 0.249571 0.515624 0.344671
ENSG00000073792 IGF2BP2 UCEC Amp 20.418360 0.356635 0.828155 0.280148
ENSG00000073792 IGF2BP2 KIRC Amp 1.404341 0.042058 0.388199 0.159091
ENSG00000073792 IGF2BP2 OV Amp 57.456754 1.112974 0.999636 0.756477