Ensembl ID ENSG00000072364 Gene ID 27125 Accession 17869
Gene Symbol AFF4 Alias MCEF;CHOPS;AF5Q31 Full Name ALF transcription elongation factor 4
Position 5 : 132875395 - 132963634 Length 88240 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011]

ENSG00000072364 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000072364 AFF4 -0.6 1.13e-17 LUSC
ENSG00000072364 AFF4 -0.7 3.66e-14 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000072364 AFF4 cancer 22547686
ENSG00000072364 AFF4 tumor 29741610
ENSG00000072364 AFF4 bladder cancer 30659266
ENSG00000072364 AFF4 bladder cancer 31228940
ENSG00000072364 AFF4 cancer 31528309
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000072364 AFF4 esophageal adenocarcinoma missense_variant 6.621% (29/438) 1 entry
ENSG00000072364 AFF4 esophageal squamous cell carcinoma stop_gained 1.481% (10/675) 2 entries
ENSG00000072364 AFF4 cecum adenocarcinoma missense_variant 5.6% (7/125) 1 entry
ENSG00000072364 AFF4 colorectal adenocarcinoma sequence_alteration 3.603% (41/1138) 1 entry
ENSG00000072364 AFF4 ovarian serous adenocarcinoma missense_variant 0.4458% (3/673) 1 entry
ENSG00000072364 AFF4 lung adenocarcinoma missense_variant 1.548% (18/1163) 5 entries
ENSG00000072364 AFF4 brain glioblastoma sequence_alteration 0.324% (3/926) 1 entry
ENSG00000072364 AFF4 basal cell carcinoma missense_variant 6.897% (4/58) 1 entry
ENSG00000072364 AFF4 colorectal adenocarcinoma frameshift_variant 3.603% (41/1138) 1 entry
ENSG00000072364 AFF4 skin melanoma stop_gained 2.172% (21/967) 1 entry
ENSG00000072364 AFF4 prostate carcinoma missense_variant 2.582% (11/426) 2 entries
ENSG00000072364 AFF4 breast carcinoma missense_variant 0.6374% (9/1412) 1 entry
ENSG00000072364 AFF4 clear cell renal carcinoma sequence_alteration 0.508% (7/1378) 1 entry
ENSG00000072364 AFF4 skin melanoma missense_variant 2.172% (21/967) 1 entry
ENSG00000072364 AFF4 oral squamous cell carcinoma missense_variant 1.463% (3/205) 1 entry
ENSG00000072364 AFF4 squamous cell lung carcinoma sequence_alteration 1.706% (13/762) 1 entry
ENSG00000072364 AFF4 colorectal adenocarcinoma missense_variant 3.603% (41/1138) 3 entries
ENSG00000072364 AFF4 squamous cell lung carcinoma stop_gained 1.706% (13/762) 1 entry
ENSG00000072364 AFF4 colon adenocarcinoma missense_variant 2.355% (17/722) 4 entries
ENSG00000072364 AFF4 esophageal adenocarcinoma frameshift_variant 6.621% (29/438) 1 entry
ENSG00000072364 AFF4 anaplastic oligodendroglioma missense_variant 4.762% (2/42) 1 entry
ENSG00000072364 AFF4 rectal adenocarcinoma missense_variant 1.357% (3/221) 1 entry
ENSG00000072364 AFF4 chronic lymphocytic leukemia missense_variant 0.3378% (3/888) 1 entry
ENSG00000072364 AFF4 pancreatic ductal adenocarcinoma missense_variant 2.621% (33/1259) 2 entries
ENSG00000072364 AFF4 B-cell acute lymphoblastic leukemia gene_fusion 3.571% (2/56) 2 entries
ENSG00000072364 AFF4 colon adenocarcinoma sequence_alteration 2.355% (17/722) 1 entry
ENSG00000072364 AFF4 esophageal squamous cell carcinoma missense_variant 1.481% (10/675) 3 entries
ENSG00000072364 AFF4 Uterine Carcinosarcoma sequence_alteration 1.818% (2/110) 1 entry
ENSG00000072364 AFF4 Breast Carcinoma by Gene Expression Profile missense_variant 10.53% (2/19) 2 entries
ENSG00000072364 AFF4 large cell lung carcinoma missense_variant 11.11% (2/18) 1 entry
ENSG00000072364 AFF4 prostate carcinoma sequence_alteration 2.582% (11/426) 1 entry
ENSG00000072364 AFF4 acute lymphoblastic leukemia gene_fusion 5.605% (19/339) 1 entry
ENSG00000072364 AFF4 colorectal adenocarcinoma stop_gained 3.603% (41/1138) 1 entry
ENSG00000072364 AFF4 clear cell renal carcinoma missense_variant 0.508% (7/1378) 4 entries
ENSG00000072364 AFF4 squamous cell lung carcinoma missense_variant 1.706% (13/762) 1 entry
ENSG00000072364 AFF4 breast carcinoma gene_fusion 0.6374% (9/1412) 1 entry
ENSG00000072364 AFF4 gastric intestinal type adenocarcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000072364 AFF4 melanoma missense_variant 1.98% (2/101) 1 entry
ENSG00000072364 AFF4 acute lymphoblastic leukemia missense_variant 5.605% (19/339) 1 entry
ENSG00000072364 AFF4 metaplastic breast carcinoma missense_variant 1.961% (1/51) 1 entry
ENSG00000072364 AFF4 prostate adenocarcinoma missense_variant 2.957% (43/1454) 1 entry
ENSG00000072364 AFF4 bladder transitional cell carcinoma missense_variant 0.7299% (1/137) 1 entry
ENSG00000072364 AFF4 adrenal cortex carcinoma missense_variant 0.6098% (1/164) 1 entry
ENSG00000072364 AFF4 prostate carcinoma frameshift_variant 2.582% (11/426) 1 entry
ENSG00000072364 AFF4 female breast carcinoma missense_variant 0.3745% (1/267) 1 entry
ENSG00000072364 AFF4 melanoma frameshift_variant 1.98% (2/101) 1 entry
ENSG00000072364 AFF4 Merkel cell skin cancer missense_variant 6.667% (2/30) 1 entry
ENSG00000072364 AFF4 Invasive Breast Carcinoma missense_variant 2.222% (1/45) 1 entry
ENSG00000072364 AFF4 Pleural Epithelioid Mesothelioma frameshift_variant 1.064% (1/94) 1 entry
ENSG00000072364 AFF4 Parathyroid Gland Carcinoma sequence_alteration 5.263% (1/19) 1 entry
ENSG00000072364 AFF4 prostate adenocarcinoma frameshift_variant 2.957% (43/1454) 1 entry
ENSG00000072364 AFF4 colonic neoplasm frameshift_variant 6.667% (1/15) 1 entry
ENSG00000072364 AFF4 acute myeloid leukemia gene_fusion 0.3304% (3/908) 1 entry
ENSG00000072364 AFF4 salivary gland mucoepidermoid carcinoma missense_variant 50.0% (1/2) 1 entry
ENSG00000072364 AFF4 diffuse large B-cell lymphoma stop_gained 0.33% (1/303) 1 entry
ENSG00000072364 AFF4 Brain Stem Glioblastoma sequence_alteration 1.786% (1/56) 1 entry
ENSG00000072364 AFF4 Gallbladder Adenocarcinoma sequence_alteration 1.149% (1/87) 1 entry
ENSG00000072364 AFF4 oral squamous cell carcinoma stop_gained 1.463% (3/205) 1 entry
ENSG00000072364 AFF4 prostate carcinoma stop_gained 2.582% (11/426) 1 entry
ENSG00000072364 AFF4 ovarian clear cell adenocarcinoma missense_variant 11.11% (1/9) 1 entry
ENSG00000072364 AFF4 Merkel cell skin cancer sequence_alteration 6.667% (2/30) 1 entry
ENSG00000072364 AFF4 angiosarcoma sequence_alteration 7.692% (1/13) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000072364 AFF4 MESO 0.031 low
ENSG00000072364 AFF4 STAD 0.031 high
ENSG00000072364 AFF4 CHOL 0.024 low
ENSG00000072364 AFF4 UVM 0.00037 high
ENSG00000072364 AFF4 PAAD 0.044 high
ENSG00000072364 AFF4 THCA 0.00055 high
ENSG00000072364 AFF4 LGG 0.027 low
ENSG00000072364 AFF4 LUSC 0.035 high
ENSG00000072364 AFF4 READ 0.037 low
ENSG00000072364 AFF4 KICH 0.012 high
ENSG00000072364 AFF4 PCPG 0.046 high
ENSG00000072364 AFF4 BRCA 0.0058 high
ENSG00000072364 AFF4 COAD 0.0087 high
ENSG00000072364 AFF4 OV 0.011 high
ENSG00000072364 AFF4 TGCT 0.028 high
ENSG00000072364 AFF4 LAML 0.036 low
ENSG00000072364 AFF4 CESC 0.011 high
ENSG00000072364 AFF4 LIHC 0.036 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000072364 AFF4 LAML Del 6.887040 0.098062 0.799843 0.089005
ENSG00000072364 AFF4 LUAD Del 3.898174 0.084346 0.350071 0.405039
ENSG00000072364 AFF4 LGG Del 0.993246 0.042209 0.393433 0.089669
ENSG00000072364 AFF4 ACC Amp 1.248228 0.334625 1.279159 0.666667
ENSG00000072364 AFF4 COAD Del 1.075218 0.046571 0.390908 0.223947
ENSG00000072364 AFF4 SKCM Del 2.641712 0.095285 0.486034 0.321526
ENSG00000072364 AFF4 HNSC Del 1.074083 0.058903 0.381352 0.394636
ENSG00000072364 AFF4 STAD Del 4.224668 0.101637 0.398456 0.335601
ENSG00000072364 AFF4 KIRC Amp 45.846925 0.272062 0.536003 0.596591
ENSG00000072364 AFF4 OV Del 1.106976 0.184368 0.559819 0.464594