Ensembl ID ENSG00000072110 Gene ID 87 Accession 163
Gene Symbol ACTN1 Alias BDPLT15 Full Name actinin alpha 1
Position 14 : 68874128 - 68979440 Length 105313 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000072110 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000072110 0.71 1.66e-14 KIRC
ENSG00000072110 -0.9 5.64e-21 PRAD
ENSG00000072110 -1.2 1.17e-26 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000072110 tumour 17167543
ENSG00000072110 tumor 17192196
ENSG00000072110 colon cancer 17898132
ENSG00000072110 tumor 18320066
ENSG00000072110 tumor 18353764
ENSG00000072110 bladder cancer 19383904
ENSG00000072110 tumor 19516963
ENSG00000072110 tumor 20037648
ENSG00000072110 rectal cancer 22188913
ENSG00000072110 tumour 24179441
ENSG00000072110 tumor 25844669
ENSG00000072110 colon cancer 25860875
ENSG00000072110 cancer 27137215
ENSG00000072110 cancer 27688707
ENSG00000072110 bladder cancer 28552713
ENSG00000072110 Cancer 28697756
ENSG00000072110 breast cancer 29742177
ENSG00000072110 cancer 30089774
ENSG00000072110 tumor 31269666
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000072110 STAD 0.019 high
ENSG00000072110 CHOL 9e-04 high
ENSG00000072110 PAAD 0.0016 high
ENSG00000072110 THCA 0.0072 high
ENSG00000072110 LUSC 0.0065 high
ENSG00000072110 HNSC 0.00028 high
ENSG00000072110 KICH 0.0078 high
ENSG00000072110 LUAD 0.00055 high
ENSG00000072110 PCPG 0.028 low
ENSG00000072110 BRCA 0.039 low
ENSG00000072110 ESCA 0.0035 low
ENSG00000072110 OV 0.0057 high
ENSG00000072110 DLBC 0.029 low
ENSG00000072110 KIRC 0.0064 high
ENSG00000072110 BLCA 0.0011 high
ENSG00000072110 LAML 0.015 low
ENSG00000072110 SKCM 0.043 high
ENSG00000072110 CESC 0.0037 high
ENSG00000072110 LIHC 0.00069 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000072110 CHOL Del 2.161196 0.327802 0.607863 0.583333
ENSG00000072110 LGG Del 10.384364 0.106366 0.545094 0.231969
ENSG00000072110 SARC Del 1.491701 0.144494 0.574422 0.307393
ENSG00000072110 GBM Del 2.369289 0.070926 0.595581 0.296360
ENSG00000072110 LIHC Del 2.943463 0.098024 0.515711 0.343243
ENSG00000072110 BLCA Del 0.684436 0.076157 0.390418 0.330882
ENSG00000072110 BRCA Del 7.933209 0.106360 0.428526 0.325926
ENSG00000072110 KIRC Del 0.613602 0.023580 0.427303 0.429924
ENSG00000072110 OV Del 4.372568 0.238781 0.537623 0.511226