Ensembl ID ENSG00000070814 Gene ID 6949 Accession 11654
Gene Symbol TCOF1 Alias TCS;MFD1;TCS1;treacle Full Name treacle ribosome biogenesis factor 1
Position 5 : 150357629 - 150400308 Length 42680 bases Strand Plus strand
Status Confidence Main interacting RNAsrRNARBP type Non-canonical_RBPs
Summary This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

ENSG00000070814 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000070814 TCOF1 0.66 6.37e-20 KIRC
ENSG00000070814 TCOF1 0.77 1.22e-15 HNSC
ENSG00000070814 TCOF1 0.54 9.21e-21 BRCA
ENSG00000070814 TCOF1 1.09 1.15e-28 COAD
ENSG00000070814 TCOF1 0.96 1.20e-11 KICH
ENSG00000070814 TCOF1 0.92 5.82e-27 LUSC
ENSG00000070814 TCOF1 0.78 1.59e-23 KIRP
ENSG00000070814 TCOF1 1.04 2.01e-29 LIHC
ENSG00000070814 TCOF1 0.87 2.75e-15 STAD
ENSG00000070814 TCOF1 1.44 2.52e-17 CHOL
ENSG00000070814 TCOF1 0.61 1.48e-13 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000070814 TCOF1 MESO 0.011 high
ENSG00000070814 TCOF1 SARC 0.038 high
ENSG00000070814 TCOF1 UCEC 0.0049 low
ENSG00000070814 TCOF1 LGG 0.0054 high
ENSG00000070814 TCOF1 READ 0.02 high
ENSG00000070814 TCOF1 KICH 0.012 high
ENSG00000070814 TCOF1 PCPG 0.014 low
ENSG00000070814 TCOF1 THYM 0.002 low
ENSG00000070814 TCOF1 UCS 0.018 high
ENSG00000070814 TCOF1 ESCA 0.0061 high
ENSG00000070814 TCOF1 DLBC 0.00029 low
ENSG00000070814 TCOF1 BLCA 0.0036 low
ENSG00000070814 TCOF1 LAML 0.012 high
ENSG00000070814 TCOF1 GBM 0.0098 high
ENSG00000070814 TCOF1 SKCM 0.0086 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000070814 TCOF1 LAML Del 6.887040 0.098062 0.803117 0.089005
ENSG00000070814 TCOF1 LGG Del 2.460712 0.056348 0.411762 0.099415
ENSG00000070814 TCOF1 ACC Amp 0.847626 0.265130 1.214118 0.677778
ENSG00000070814 TCOF1 SKCM Del 5.870199 0.131275 0.494562 0.332425
ENSG00000070814 TCOF1 KIRC Amp 52.401218 0.297192 0.545124 0.611742