Ensembl ID ENSG00000067225 Gene ID 5315 Accession 9021
Gene Symbol PKM Alias PK3;TCB;p58;OIP3;PKM2;CTHBP;THBP1;HEL-S-30 Full Name pyruvate kinase M1/2
Position 15 : 72199029 - 72231819 Length 32791 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]

ENSG00000067225 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000067225 0.58 2.09e-16 KIRC
ENSG00000067225 0.89 7.49e-44 BRCA
ENSG00000067225 0.95 1.64e-16 COAD
ENSG00000067225 1.43 7.43e-52 LUSC
ENSG00000067225 0.75 1.26e-12 KIRP
ENSG00000067225 1.81 8.27e-17 LIHC
ENSG00000067225 1.70 3.27e-45 UCEC
ENSG00000067225 4.13 2.62e-45 CHOL
ENSG00000067225 0.91 1.37e-22 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000067225 tumor 10470235
ENSG00000067225 Tumor 11198266
ENSG00000067225 cancer 11326647
ENSG00000067225 gastric cancer 11326648
ENSG00000067225 tumor 11326667
ENSG00000067225 tumor 11326687
ENSG00000067225 lung cancer 12017309
ENSG00000067225 breast cancer 12359372
ENSG00000067225 small-cell lung cancer 12624710
ENSG00000067225 lung cancer 12691828
ENSG00000067225 colorectal cancer 12820312
ENSG00000067225 cancer 12820313
ENSG00000067225 lung cancer 12820320
ENSG00000067225 tumor 12820359
ENSG00000067225 tumor 12820363
ENSG00000067225 neuroendocrine tumors 12926146
ENSG00000067225 cancers 14646575
ENSG00000067225 cancer 14981971
ENSG00000067225 tumor 15148526
ENSG00000067225 tumor 15908230
ENSG00000067225 tumor 15957165
ENSG00000067225 tumor 16033052
ENSG00000067225 tumor 16315127
ENSG00000067225 breast cancer 17105229
ENSG00000067225 Colorectal cancer 17109496
ENSG00000067225 tumors 17123452
ENSG00000067225 lung cancer 17131623
ENSG00000067225 cancer 17308100
ENSG00000067225 tumor 17602267
ENSG00000067225 colorectal cancer 17649802
ENSG00000067225 cancer 18191611
ENSG00000067225 cancer 18261916
ENSG00000067225 breast cancer 18298799
ENSG00000067225 cancers 18464261
ENSG00000067225 tumor 18603432
ENSG00000067225 colorectal cancer 18785806
ENSG00000067225 tumour 18811055
ENSG00000067225 cancer 19075689
ENSG00000067225 tumor 19221597
ENSG00000067225 cancer 19273305
ENSG00000067225 tumor 19401544
ENSG00000067225 tumor 19776420
ENSG00000067225 tumor 19920251
ENSG00000067225 Cancer 20005212
ENSG00000067225 cancer 20010808
ENSG00000067225 tumor 20017496
ENSG00000067225 ovarian cancer 20082317
ENSG00000067225 tumor 20156581
ENSG00000067225 tumor 20304929
ENSG00000067225 tumor 20336315
ENSG00000067225 tumor 20451379
ENSG00000067225 breast cancers 20495363
ENSG00000067225 tumor 20507318
ENSG00000067225 cancer 20667897
ENSG00000067225 tumors 20721957
ENSG00000067225 cancer 20811631
ENSG00000067225 cancer 20847263
ENSG00000067225 tumor 20857498
ENSG00000067225 tumor 20927531
ENSG00000067225 tumor 20978194
ENSG00000067225 tumors 21113295
ENSG00000067225 malignant tumors 21130743
ENSG00000067225 tumor 21305022
ENSG00000067225 GBM 21317451
ENSG00000067225 cancer 21325052
ENSG00000067225 tumor 21334407
ENSG00000067225 tumor 21437190
ENSG00000067225 tumors 21501490
ENSG00000067225 cancer 21516121
ENSG00000067225 tumor 21526124
ENSG00000067225 tumor 21569526
ENSG00000067225 Tumors 21573193
ENSG00000067225 cancer 21620138
ENSG00000067225 tumor 21673231
ENSG00000067225 cancer 21700216
ENSG00000067225 Tumor 21700219
ENSG00000067225 tumor 21708025
ENSG00000067225 cancer 21709315
ENSG00000067225 cancer 21725354
ENSG00000067225 tumor 21779721
ENSG00000067225 cancer 21785006
ENSG00000067225 cancers 21789790
ENSG00000067225 lung cancer 21826988
ENSG00000067225 tumor 21904528
ENSG00000067225 cancers 21907146
ENSG00000067225 cancer 21958545
ENSG00000067225 tumor 22009386
ENSG00000067225 lung cancer 22052977
ENSG00000067225 cancer 22056988
ENSG00000067225 tumor 22087286
ENSG00000067225 tumors 22123234
ENSG00000067225 breast cancer 22140559
ENSG00000067225 cancer 22154083
ENSG00000067225 tumor 22200182
ENSG00000067225 colorectal cancer 22200720
ENSG00000067225 cancer 22213464
ENSG00000067225 tumor 22236875
ENSG00000067225 cancer 22237205
ENSG00000067225 tumor 22261915
ENSG00000067225 tumors 22262476
ENSG00000067225 cancer 22271574
ENSG00000067225 cancer 22293754
ENSG00000067225 tumor 22330683
ENSG00000067225 cancer 22334075
ENSG00000067225 tumors 22407012
ENSG00000067225 pancreatic tumor 22412968
ENSG00000067225 cancer 22433951
ENSG00000067225 tumor 22509023
ENSG00000067225 tumors 22515442
ENSG00000067225 cancer 22574221
ENSG00000067225 breast cancer 22580449
ENSG00000067225 cancer 22626471
ENSG00000067225 gastric cancer 22627140
ENSG00000067225 tumors 22807066
ENSG00000067225 cancer 22824010
ENSG00000067225 breast tumor 22874552
ENSG00000067225 colorectal cancer 22895557
ENSG00000067225 cancer 22898868
ENSG00000067225 Tumor 22901803
ENSG00000067225 Tumour 22912551
ENSG00000067225 cancer 22912555
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ENSG00000067225 cancer 23086999
ENSG00000067225 tumor 23123196
ENSG00000067225 breast cancer 23130662
ENSG00000067225 cancer 23154538
ENSG00000067225 brain tumor 23178880
ENSG00000067225 cancer 23212076
ENSG00000067225 skin cancer 23255458
ENSG00000067225 tumors 23267074
ENSG00000067225 tumour 23301832
ENSG00000067225 cancer 23317289
ENSG00000067225 cancer 23319410
ENSG00000067225 cancer 23346549
ENSG00000067225 tumors 23388203
ENSG00000067225 cancer 23421205
ENSG00000067225 cancer 23425920
ENSG00000067225 prostate cancer 23441447
ENSG00000067225 GBM 23451252
ENSG00000067225 cancer 23470539
ENSG00000067225 cancer 23471124
ENSG00000067225 Cancer 23476652
ENSG00000067225 tumor 23508580
ENSG00000067225 liver cancer 23515579
ENSG00000067225 tumor 23586047
ENSG00000067225 cancer 23622982
ENSG00000067225 tumor 23625175
ENSG00000067225 lung tumor 23720766
ENSG00000067225 colon cancer 23737015
ENSG00000067225 cancer 23762063
ENSG00000067225 tumor 23762265
ENSG00000067225 cancer 23764845
ENSG00000067225 cancer 23791887
ENSG00000067225 gallbladder cancer 23793810
ENSG00000067225 tumor 23814019
ENSG00000067225 tumor 23829383
ENSG00000067225 cancer 23837608
ENSG00000067225 gastric cancer 23840737
ENSG00000067225 papillary thyroid cancer 23846818
ENSG00000067225 tumor 23859618
ENSG00000067225 cancer 23863156
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ENSG00000067225 tumor 23921685
ENSG00000067225 Cancer 23961261
ENSG00000067225 cancer 24013426
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ENSG00000067225 tumour 24058603
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ENSG00000067225 cancer 24142698
ENSG00000067225 ovarian cancer 24252137
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ENSG00000067225 tumor 24318446
ENSG00000067225 cancer 24344305
ENSG00000067225 Cancer 24363178
ENSG00000067225 cancer 24418892
ENSG00000067225 lung cancer 24450150
ENSG00000067225 tumors 24466275
ENSG00000067225 tumour 24476821
ENSG00000067225 tumors 24481450
ENSG00000067225 cancer 24491179
ENSG00000067225 cancer 24492614
ENSG00000067225 cervical cancer 24506961
ENSG00000067225 cancer 24508027
ENSG00000067225 tumors 24551779
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ENSG00000067225 cancer 24598263
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ENSG00000067225 cancer 24657017
ENSG00000067225 tumor 24658033
ENSG00000067225 cancer 24672582
ENSG00000067225 tumours 24699711
ENSG00000067225 breast cancer 24710512
ENSG00000067225 cancer 24735734
ENSG00000067225 Cancer 24747424
ENSG00000067225 tongue cancer 24762230
ENSG00000067225 cancer 24790978
ENSG00000067225 cancer 24792468
ENSG00000067225 cancer 24795025
ENSG00000067225 prostate cancer 24859886
ENSG00000067225 prostate cancer 24884829
ENSG00000067225 tumor 24895527
ENSG00000067225 colon cancer 24898807
ENSG00000067225 tumor 24911170
ENSG00000067225 cancer 24928511
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ENSG00000067225 Cancer 24972138
ENSG00000067225 tumor 24982407
ENSG00000067225 tumour 24990612
ENSG00000067225 cancer 24995504
ENSG00000067225 cancer 25019241
ENSG00000067225 prostate cancer 25029852
ENSG00000067225 tumor 25041845
ENSG00000067225 tumor 25064846
ENSG00000067225 tumor 25070887
ENSG00000067225 cancer 25078136
ENSG00000067225 cancer 25089263
ENSG00000067225 tumor 25118927
ENSG00000067225 tumor 25188891
ENSG00000067225 Pancreatic Cancer 25197966
ENSG00000067225 cancer 25208557
ENSG00000067225 cancer 25214764
ENSG00000067225 precancerous condition 25215525
ENSG00000067225 non-small-cell lung cancer 25233397
ENSG00000067225 cancer 25237859
ENSG00000067225 cancer 25242333
ENSG00000067225 cancer 25243088
ENSG00000067225 cancer 25260566
ENSG00000067225 cancer 25263439
ENSG00000067225 bladder cancer 25266796
ENSG00000067225 tumor 25277190
ENSG00000067225 tumor 25289083
ENSG00000067225 cancer 25313085
ENSG00000067225 cancer 25337566
ENSG00000067225 ovarian cancer 25405516
ENSG00000067225 pancreatic cancer 25411978
ENSG00000067225 tumor 25412762
ENSG00000067225 breast cancer 25426101
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ENSG00000067225 cancers 25444918
ENSG00000067225 colorectal cancer 25450288
ENSG00000067225 triple-negative breast cancer 25450685
ENSG00000067225 tumors 25471892
ENSG00000067225 cancer 25473070
ENSG00000067225 tumor 25482511
ENSG00000067225 lung cancer 25483567
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ENSG00000067225 cancer 25621950
ENSG00000067225 cancer 25644089
ENSG00000067225 cancer 25645022
ENSG00000067225 Non-small cell Lung Cancer 25649613
ENSG00000067225 liver cancer 25661370
ENSG00000067225 cancer 25685782
ENSG00000067225 cancer 25703326
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ENSG00000067225 tumor 25721733
ENSG00000067225 colon cancer 25732087
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ENSG00000067225 cancer 25748049
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ENSG00000067225 tumor 25844669
ENSG00000067225 tumor 25855294
ENSG00000067225 tumor 25859558
ENSG00000067225 cancer 25870517
ENSG00000067225 thyroid cancer 25880801
ENSG00000067225 cervical cancer 25893434
ENSG00000067225 cancer 25897425
ENSG00000067225 colorectal cancer 25904505
ENSG00000067225 cervical cancer 25936600
ENSG00000067225 tumor 25945836
ENSG00000067225 tumor 25948776
ENSG00000067225 Colorectal Cancer 25955657
ENSG00000067225 tumor 25957288
ENSG00000067225 tumor 25961580
ENSG00000067225 Ovarian Cancer 25964202
ENSG00000067225 cancer 25970228
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ENSG00000067225 cancer 25985625
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ENSG00000067225 cancer 26082202
ENSG00000067225 tumor 26092770
ENSG00000067225 tumor 26097714
ENSG00000067225 gastric cancer 26101707
ENSG00000067225 pancreatic cancer 26112218
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ENSG00000067225 cancer 26124389
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ENSG00000067225 lung cancer 26140362
ENSG00000067225 tumor 26144048
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ENSG00000067225 cancer 26164081
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ENSG00000067225 cancer 26183399
ENSG00000067225 triple negative breast cancer 26193000
ENSG00000067225 cancer 26234680
ENSG00000067225 tumor 26242036
ENSG00000067225 metastatic colorectal cancer 26252736
ENSG00000067225 cancer 26258887
ENSG00000067225 tumors 26266538
ENSG00000067225 cancer 26269597
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ENSG00000067225 lung cancer 26273407
ENSG00000067225 cancer 26273627
ENSG00000067225 cancer 26277545
ENSG00000067225 cancer 26283370
ENSG00000067225 cancer 26291325
ENSG00000067225 cancer 26300261
ENSG00000067225 colorectal cancer 26317652
ENSG00000067225 nonsmall cell lung cancer 26323904
ENSG00000067225 breast cancer 26339369
ENSG00000067225 tumors 26342198
ENSG00000067225 cancer 26345567
ENSG00000067225 Thyroid cancer 26362676
ENSG00000067225 cancer 26367460
ENSG00000067225 cancers 26375396
ENSG00000067225 tumor 26376677
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ENSG00000067225 tumor 26491079
ENSG00000067225 breast cancer 26493994
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ENSG00000067225 breast cancer 26516361
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ENSG00000067225 breast cancer 26536104
ENSG00000067225 laryngeal cancer 26540912
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ENSG00000067225 cancer 26708302
ENSG00000067225 triple-negative breast cancer 26715276
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ENSG00000067225 gastric cancer 26745603
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ENSG00000067225 tumor 26787900
ENSG00000067225 cancer 26791262
ENSG00000067225 brain tumor 26861698
ENSG00000067225 tumor 26870273
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ENSG00000067225 Cancer 26877834
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ENSG00000067225 Cancer 26917721
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ENSG00000067225 breast cancer 26926077
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ENSG00000067225 colon tumors 26927284
ENSG00000067225 Cancer 26948869
ENSG00000067225 Lung Cancer 26951145
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ENSG00000067225 cancer 27012213
ENSG00000067225 esophageal cancer 27040384
ENSG00000067225 tumor 27045080
ENSG00000067225 breast cancer 27069552
ENSG00000067225 lung cancer 27073574
ENSG00000067225 cancer 27092877
ENSG00000067225 Colorectal Tumors 27098621
ENSG00000067225 cancer 27125672
ENSG00000067225 tumor 27138141
ENSG00000067225 cancer 27148264
ENSG00000067225 Cancers 27149849
ENSG00000067225 cancer 27152240
ENSG00000067225 liver cancer 27167190
ENSG00000067225 cancers 27187079
ENSG00000067225 cancer 27197174
ENSG00000067225 liver cancer 27203546
ENSG00000067225 cancer 27213336
ENSG00000067225 cancer 27225801
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ENSG00000067225 cancer 27279169
ENSG00000067225 cancer 27282387
ENSG00000067225 gallbladder cancer 27283076
ENSG00000067225 cancer 27308346
ENSG00000067225 cancer 27308628
ENSG00000067225 cancer 27313493
ENSG00000067225 cancer 27323830
ENSG00000067225 lung cancer 27340866
ENSG00000067225 cancers 27356757
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ENSG00000067225 Cancer 27384996
ENSG00000067225 cancer 27385486
ENSG00000067225 lung cancer 27418963
ENSG00000067225 cancer 27431728
ENSG00000067225 cancer 27458133
ENSG00000067225 tumor 27478385
ENSG00000067225 cancer 27481063
ENSG00000067225 tumour 27485204
ENSG00000067225 cervical cancer 27492148
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ENSG00000067225 cancer 27510264
ENSG00000067225 cancer 27512079
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ENSG00000067225 cancer 27593857
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ENSG00000067225 cancer 27651854
ENSG00000067225 cancer 27683215
ENSG00000067225 Prostate Cancer 27696457
ENSG00000067225 gastric cancer 27696637
ENSG00000067225 esophageal cancer 27703488
ENSG00000067225 tumors 27726115
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ENSG00000067225 cancer 27779186
ENSG00000067225 pancreatic cancer 27785603
ENSG00000067225 cervical cancer 27801666
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ENSG00000067225 Cancer 27960279
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ENSG00000067225 pancreas cancer 27989750
ENSG00000067225 brain tumor 28035139
ENSG00000067225 Tumor 28036303
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ENSG00000067225 ovarian cancer 28380434
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Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000067225 UVM 0.00019 high
ENSG00000067225 LGG 0.0033 high
ENSG00000067225 HNSC 0.00016 high
ENSG00000067225 KICH 0.0035 high
ENSG00000067225 PCPG 0.02 high
ENSG00000067225 THYM 0.0025 high
ENSG00000067225 BRCA 0.039 high
ENSG00000067225 COAD 0.0068 high
ENSG00000067225 OV 0.0034 high
ENSG00000067225 DLBC 0.018 low
ENSG00000067225 TGCT 0.027 high
ENSG00000067225 BLCA 0.029 high
ENSG00000067225 LAML 0.00018 high
ENSG00000067225 GBM 0.049 high
ENSG00000067225 SKCM 0.0058 high
ENSG00000067225 CESC 0.0032 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000067225 SKCM Amp 1.204831 0.137047 0.498704 0.294278