Ensembl ID ENSG00000065427 Gene ID 3735 Accession 6215
Gene Symbol KARS1 Alias KRS;KARS;KARS2;LEPID;CMTRIB;DEAPLE;DFNB89 Full Name lysyl-tRNA synthetase 1
Position 16 : 75627474 - 75647665 Length 20192 bases Strand Minus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000065427 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000065427 KARS 0.55 3.39e-18 COAD
ENSG00000065427 KARS 0.60 4.85e-17 LUSC
ENSG00000065427 KARS 0.44 3.22e-11 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000065427 KARS metastatic colorectal cancer 19549774
ENSG00000065427 KARS cancer 22751010
ENSG00000065427 KARS cancer 24212136
ENSG00000065427 KARS cancer 24312579
ENSG00000065427 KARS breast cancer 24510587
ENSG00000065427 KARS tumor 24558064
ENSG00000065427 KARS cancer 24983501
ENSG00000065427 KARS cancer 25535072
ENSG00000065427 KARS tumors 25623536
ENSG00000065427 KARS colon cancer 26091349
ENSG00000065427 KARS cancer 26670257
ENSG00000065427 KARS cancer 26891990
ENSG00000065427 KARS colorectal cancer 27215512
ENSG00000065427 KARS cancer 27663887
ENSG00000065427 KARS cancer 28611052
ENSG00000065427 KARS Cancer 28626001
ENSG00000065427 KARS tumor 29029422
ENSG00000065427 KARS colon cancer 29288497
ENSG00000065427 KARS cancers 30980774
ENSG00000065427 KARS lung cancer 31050289
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000065427 KARS PAAD 0.016 high
ENSG00000065427 KARS UCEC 0.02 low
ENSG00000065427 KARS THCA 0.03 low
ENSG00000065427 KARS KIRP 0.024 high
ENSG00000065427 KARS KICH 0.00048 low
ENSG00000065427 KARS LUAD 0.0091 high
ENSG00000065427 KARS PCPG 0.016 high
ENSG00000065427 KARS ESCA 0.0016 high
ENSG00000065427 KARS OV 0.02 low
ENSG00000065427 KARS KIRC 0.00026 low
ENSG00000065427 KARS LAML 0.028 high
ENSG00000065427 KARS GBM 0.00096 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000065427 KARS LAML Del 2.192563 0.050448 0.644287 0.041885
ENSG00000065427 KARS LUAD Del 0.931774 0.054552 0.319147 0.317829
ENSG00000065427 KARS UCS Del 0.609938 0.193330 0.567695 0.678571
ENSG00000065427 KARS TGCT Del 1.679425 0.080838 0.346365 0.420000
ENSG00000065427 KARS BRCA Del 0.709367 0.063355 0.519811 0.625000
ENSG00000065427 KARS PRAD Del 22.842037 0.217410 0.538478 0.384146
ENSG00000065427 KARS UCEC Del 5.215810 0.090187 0.627151 0.296846
ENSG00000065427 KARS OV Del 7.015932 0.269821 0.660725 0.768566