Ensembl ID
ENSG00000063244
Gene ID
11338
Accession
23156
Gene Symbol
U2AF2
Alias
U2AF65
Full Name
U2 small nuclear RNA auxiliary factor 2
Position
19 : 55654146 - 55674716
Length
20571 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs mRNA RBP type
Canonical_RBPs
Summary
U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]
ENSG00000063244 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000063244
U2AF2
0.73
1.80e-55
BRCA
ENSG00000063244
U2AF2
0.78
4.47e-34
LUSC
ENSG00000063244
U2AF2
0.40
1.18e-13
LIHC
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000063244
U2AF2
colorectal tumors
22682314
ENSG00000063244
U2AF2
cancer
22792276
ENSG00000063244
U2AF2
AML
23645565
ENSG00000063244
U2AF2
pancreatic cancer
25174478
ENSG00000063244
U2AF2
tumor
25642226
ENSG00000063244
U2AF2
tumors
26406946
ENSG00000063244
U2AF2
tumor
27041584
ENSG00000063244
U2AF2
cancer
27720643
ENSG00000063244
U2AF2
Cancer
28850223
ENSG00000063244
U2AF2
colon cancers
29176719
ENSG00000063244
U2AF2
tumors
29275860
ENSG00000063244
U2AF2
non-small cell lung cancer
30662561
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000063244
U2AF2
MESO
0.013
high
show
ENSG00000063244
U2AF2
SARC
0.00027
high
show
ENSG00000063244
U2AF2
STAD
0.003
low
show
ENSG00000063244
U2AF2
UVM
0.0042
high
show
ENSG00000063244
U2AF2
PAAD
0.027
low
show
ENSG00000063244
U2AF2
UCEC
0.0061
low
show
ENSG00000063244
U2AF2
ACC
0.0017
high
show
ENSG00000063244
U2AF2
HNSC
0.026
high
show
ENSG00000063244
U2AF2
KIRP
0.016
high
show
ENSG00000063244
U2AF2
KICH
0.043
high
show
ENSG00000063244
U2AF2
LUAD
0.0078
high
show
ENSG00000063244
U2AF2
PCPG
0.049
high
show
ENSG00000063244
U2AF2
THYM
0.0045
low
show
ENSG00000063244
U2AF2
ESCA
0.028
high
show
ENSG00000063244
U2AF2
KIRC
0.00014
high
show
ENSG00000063244
U2AF2
PRAD
0.019
low
show
ENSG00000063244
U2AF2
BLCA
0.022
low
show
ENSG00000063244
U2AF2
LAML
0.043
high
show
ENSG00000063244
U2AF2
GBM
0.042
low
show
ENSG00000063244
U2AF2
SKCM
0.0034
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000063244
U2AF2
LUSC
Del
2.277323
0.086439
0.362944
0.253493
ENSG00000063244
U2AF2
LUAD
Del
0.957629
0.054972
0.322711
0.335271
ENSG00000063244
U2AF2
LGG
Del
27.315752
0.185085
0.661979
0.538012
ENSG00000063244
U2AF2
CESC
Amp
0.710411
0.128400
0.573174
0.318644
ENSG00000063244
U2AF2
SARC
Del
3.948542
0.197994
0.440839
0.338521
ENSG00000063244
U2AF2
GBM
Del
8.660394
0.117084
0.537322
0.143847
ENSG00000063244
U2AF2
TGCT
Del
1.074585
0.064959
0.339375
0.380000
ENSG00000063244
U2AF2
DLBC
Amp
1.472895
0.262236
0.709977
0.187500
ENSG00000063244
U2AF2
BLCA
Amp
1.833823
0.204550
0.489542
0.397059
ENSG00000063244
U2AF2
BRCA
Amp
2.523473
0.178414
0.533525
0.258333
ENSG00000063244
U2AF2
UCEC
Del
0.757541
0.048408
0.469947
0.103896
ENSG00000063244
U2AF2
OV
Del
9.824579
0.298243
0.574185
0.452504
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