Ensembl ID ENSG00000062822 Gene ID 5424 Accession 9175
Gene Symbol POLD1 Alias CDC2;MDPL;POLD;CRCS10 Full Name DNA polymerase delta 1, catalytic subunit
Position 19 : 50384204 - 50418018 Length 33815 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]

ENSG00000062822 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000062822 0.70 4.63e-27 KIRC
ENSG00000062822 0.97 8.60e-23 HNSC
ENSG00000062822 1.37 4.26e-18 BLCA
ENSG00000062822 1.00 8.47e-40 BRCA
ENSG00000062822 0.95 4.46e-14 COAD
ENSG00000062822 1.13 1.31e-31 LUSC
ENSG00000062822 0.89 5.39e-32 KIRP
ENSG00000062822 1.26 6.20e-33 LIHC
ENSG00000062822 1.07 1.15e-12 STAD
ENSG00000062822 1.32 2.04e-22 UCEC
ENSG00000062822 2.24 8.22e-11 CESC
ENSG00000062822 0.58 6.88e-11 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000062822 tumor 11375983
ENSG00000062822 colon cancer 14767555
ENSG00000062822 breast cancer 15113441
ENSG00000062822 bladder cancer 17203305
ENSG00000062822 prostate cancer 18586725
ENSG00000062822 breast cancer 18701435
ENSG00000062822 tumor 21372597
ENSG00000062822 breast cancer 21700777
ENSG00000062822 tumor 22142811
ENSG00000062822 tumours 23263490
ENSG00000062822 tumour 23447401
ENSG00000062822 tumour 23528559
ENSG00000062822 endometrial cancers 23770608
ENSG00000062822 tumor 24303203
ENSG00000062822 familial colorectal cancer 24501277
ENSG00000062822 colorectal cancer 24509466
ENSG00000062822 tumors 24583393
ENSG00000062822 colorectal cancer 24705290
ENSG00000062822 tumours 24788313
ENSG00000062822 endometrial cancer 24838932
ENSG00000062822 cancer 25187488
ENSG00000062822 Tumor 25194673
ENSG00000062822 tumor 25716913
ENSG00000062822 cancer 25827231
ENSG00000062822 tumour 25827447
ENSG00000062822 tumors 25949894
ENSG00000062822 endometrial cancer 26133394
ENSG00000062822 tumor 26648449
ENSG00000062822 tumors 26748215
ENSG00000062822 colorectal cancer 26755646
ENSG00000062822 AML 26817437
ENSG00000062822 breast cancer 27022290
ENSG00000062822 colorectal cancer 27279102
ENSG00000062822 cancer 27320729
ENSG00000062822 cancers 27325016
ENSG00000062822 cancer 27573199
ENSG00000062822 cancer 28117753
ENSG00000062822 tumors 28218421
ENSG00000062822 breast cancer 28252032
ENSG00000062822 cancer 28306219
ENSG00000062822 tumour 28331556
ENSG00000062822 tumors 28368425
ENSG00000062822 tumor 28405512
ENSG00000062822 colorectal cancer 28423643
ENSG00000062822 tumors 28427513
ENSG00000062822 cancer 28521875
ENSG00000062822 stomach cancer 28582771
ENSG00000062822 tumours 28805995
ENSG00000062822 CNS tumors 28976792
ENSG00000062822 colorectal cancer 29120461
ENSG00000062822 colorectal cancer 29296022
ENSG00000062822 tumors 29361689
ENSG00000062822 colorectal cancer 29388942
ENSG00000062822 cancer 29406563
ENSG00000062822 tumor 29445424
ENSG00000062822 tumours 29604063
ENSG00000062822 tumors 29717118
ENSG00000062822 cervical cancer 29719595
ENSG00000062822 tumor 29763623
ENSG00000062822 breast cancer 29807012
ENSG00000062822 tumors 29854292
ENSG00000062822 Colorectal Cancer 29876237
ENSG00000062822 Cancer 30009279
ENSG00000062822 Colorectal Cancer 30086056
ENSG00000062822 tumors 30211169
ENSG00000062822 cancer 30257222
ENSG00000062822 cancer 30275357
ENSG00000062822 tumors 30291241
ENSG00000062822 breast cancer 30344713
ENSG00000062822 endometrial cancer 30524909
ENSG00000062822 tumor 30623082
ENSG00000062822 renal cancer 30680046
ENSG00000062822 colorectal cancer 30683709
ENSG00000062822 tumor 30827058
ENSG00000062822 endometrial cancer 30925862
ENSG00000062822 tumors 31047727
ENSG00000062822 tumors 31114938
ENSG00000062822 colorectal cancer 31136750
ENSG00000062822 tumor 31240875
ENSG00000062822 cancer 31278166
ENSG00000062822 tumors 31285513
ENSG00000062822 tumor 31410780
ENSG00000062822 Cancer 31415061
ENSG00000062822 tumor 31539077
ENSG00000062822 cancer 31576098
ENSG00000062822 cancer 31624068
ENSG00000062822 lung cancer 31673068
ENSG00000062822 cancers 31741177
ENSG00000062822 tumor 31857678
ENSG00000062822 cancer 31866764
ENSG00000062822 cancer 31944473
ENSG00000062822 tumors 9331571
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000062822 colon adenocarcinoma missense_variant 4.695% (60/1278) 9 entries
ENSG00000062822 colon adenocarcinoma sequence_alteration 4.695% (60/1278) 1 entry
ENSG00000062822 colorectal adenocarcinoma stop_gained 5.243% (69/1316) 1 entry
ENSG00000062822 colorectal adenocarcinoma missense_variant 5.243% (69/1316) 9 entries
ENSG00000062822 colon adenocarcinoma stop_gained 4.695% (60/1278) 2 entries
ENSG00000062822 colon adenocarcinoma frameshift_variant 4.695% (60/1278) 6 entries
ENSG00000062822 colorectal adenocarcinoma frameshift_variant 5.243% (69/1316) 2 entries
ENSG00000062822 colorectal adenocarcinoma sequence_alteration 5.243% (69/1316) 2 entries
ENSG00000062822 anaplastic oligodendroglioma missense_variant 2.326% (2/86) 1 entry
ENSG00000062822 melanoma missense_variant 2.759% (4/145) 2 entries
ENSG00000062822 B-cell acute lymphoblastic leukemia missense_variant 3.704% (2/54) 1 entry
ENSG00000062822 Endometrial Endometrioid Adenocarcinoma stop_gained 2.381% (20/840) 2 entries
ENSG00000062822 lung adenocarcinoma sequence_alteration 1.063% (29/2727) 1 entry
ENSG00000062822 esophageal adenocarcinoma missense_variant 2.742% (15/547) 2 entries
ENSG00000062822 Endometrial Endometrioid Adenocarcinoma missense_variant 2.381% (20/840) 2 entries
ENSG00000062822 ovarian serous adenocarcinoma missense_variant 0.2401% (2/833) 2 entries
ENSG00000062822 breast carcinoma missense_variant 0.7968% (12/1506) 2 entries
ENSG00000062822 Thyroid Gland Undifferentiated (Anaplastic) Carcinoma missense_variant 0.7576% (2/264) 1 entry
ENSG00000062822 lobular breast carcinoma missense_variant 1.21% (3/248) 2 entries
ENSG00000062822 cecum adenocarcinoma missense_variant 4.528% (12/265) 2 entries
ENSG00000062822 Merkel cell skin cancer missense_variant 2.151% (2/93) 2 entries
ENSG00000062822 female breast carcinoma missense_variant 1.124% (3/267) 1 entry
ENSG00000062822 clear cell renal carcinoma missense_variant 0.534% (8/1498) 3 entries
ENSG00000062822 bladder transitional cell carcinoma missense_variant 2.418% (11/455) 2 entries
ENSG00000062822 pancreatic ductal adenocarcinoma missense_variant 1.367% (23/1683) 2 entries
ENSG00000062822 Cervical Small Cell Carcinoma missense_variant 25.0% (2/8) 1 entry
ENSG00000062822 head and neck squamous cell carcinoma missense_variant 0.9539% (6/629) 1 entry
ENSG00000062822 bladder carcinoma missense_variant 1.068% (6/562) 1 entry
ENSG00000062822 hepatocellular carcinoma missense_variant 1.117% (11/985) 1 entry
ENSG00000062822 skin melanoma missense_variant 1.897% (22/1160) 5 entries
ENSG00000062822 non-small cell lung carcinoma missense_variant 2.083% (2/96) 2 entries
ENSG00000062822 brain glioblastoma missense_variant 0.5477% (7/1278) 2 entries
ENSG00000062822 acute myeloid leukemia missense_variant 0.5929% (6/1012) 1 entry
ENSG00000062822 prostate adenocarcinoma sequence_alteration 0.8376% (18/2149) 1 entry
ENSG00000062822 gastric intestinal type adenocarcinoma missense_variant 2.353% (2/85) 1 entry
ENSG00000062822 basal cell carcinoma missense_variant 4.412% (3/68) 1 entry
ENSG00000062822 breast carcinoma frameshift_variant 0.7968% (12/1506) 1 entry
ENSG00000062822 prostate carcinoma sequence_alteration 1.174% (5/426) 1 entry
ENSG00000062822 lung adenocarcinoma missense_variant 1.063% (29/2727) 5 entries
ENSG00000062822 head and neck squamous cell carcinoma sequence_alteration 0.9539% (6/629) 1 entry
ENSG00000062822 cecum adenocarcinoma sequence_alteration 4.528% (12/265) 2 entries
ENSG00000062822 diffuse large B-cell lymphoma missense_variant 0.5391% (2/371) 2 entries
ENSG00000062822 small cell lung carcinoma missense_variant 1.357% (6/442) 3 entries
ENSG00000062822 prostate adenocarcinoma missense_variant 0.8376% (18/2149) 2 entries
ENSG00000062822 oral squamous cell carcinoma missense_variant 1.908% (5/262) 4 entries
ENSG00000062822 urothelial carcinoma missense_variant 4.651% (4/86) 1 entry
ENSG00000062822 gastric adenocarcinoma missense_variant 2.222% (16/720) 1 entry
ENSG00000062822 squamous cell lung carcinoma missense_variant 0.6438% (6/932) 1 entry
ENSG00000062822 endometrial carcinoma missense_variant 1.471% (1/68) 1 entry
ENSG00000062822 chronic myelomonocytic leukemia missense_variant 3.704% (1/27) 1 entry
ENSG00000062822 prostate carcinoma frameshift_variant 1.174% (5/426) 1 entry
ENSG00000062822 skin melanoma sequence_alteration 1.897% (22/1160) 1 entry
ENSG00000062822 bladder transitional cell carcinoma stop_gained 2.418% (11/455) 1 entry
ENSG00000062822 Sinonasal Undifferentiated Carcinoma missense_variant 8.333% (1/12) 1 entry
ENSG00000062822 chronic lymphocytic leukemia sequence_alteration 0.2245% (2/891) 1 entry
ENSG00000062822 Anal Squamous Cell Carcinoma missense_variant 1.22% (1/82) 1 entry
ENSG00000062822 bile duct adenocarcinoma missense_variant 0.1603% (1/624) 1 entry
ENSG00000062822 papillary thyroid carcinoma missense_variant 0.2045% (1/489) 1 entry
ENSG00000062822 anaplastic astrocytoma sequence_alteration 1.449% (2/138) 1 entry
ENSG00000062822 Gallbladder Adenocarcinoma sequence_alteration 0.5917% (1/169) 1 entry
ENSG00000062822 brain glioblastoma sequence_alteration 0.5477% (7/1278) 1 entry
ENSG00000062822 small cell lung carcinoma frameshift_variant 1.357% (6/442) 1 entry
ENSG00000062822 Invasive Breast Carcinoma missense_variant 2.222% (1/45) 1 entry
ENSG00000062822 basal cell carcinoma sequence_alteration 4.412% (3/68) 1 entry
ENSG00000062822 glioma sequence_alteration 0.3257% (2/614) 1 entry
ENSG00000062822 Mixed Lobular and Ductal Breast Carcinoma missense_variant 1.408% (1/71) 1 entry
ENSG00000062822 breast ductal adenocarcinoma stop_gained 1.319% (22/1668) 1 entry
ENSG00000062822 colon carcinoma missense_variant 12.5% (1/8) 1 entry
ENSG00000062822 breast ductal adenocarcinoma frameshift_variant 1.319% (22/1668) 1 entry
ENSG00000062822 mucosal melanoma missense_variant 1.429% (1/70) 1 entry
ENSG00000062822 clear cell renal carcinoma sequence_alteration 0.534% (8/1498) 1 entry
ENSG00000062822 undifferentiated pleomorphic sarcoma missense_variant 1.613% (1/62) 1 entry
ENSG00000062822 Tracheal Squamous Cell Carcinoma missense_variant 50.0% (1/2) 1 entry
ENSG00000062822 lung adenocarcinoma frameshift_variant 1.063% (29/2727) 1 entry
ENSG00000062822 esophageal adenocarcinoma frameshift_variant 2.742% (15/547) 1 entry
ENSG00000062822 skin melanoma frameshift_variant 1.897% (22/1160) 1 entry
ENSG00000062822 Duodenal Adenocarcinoma frameshift_variant 5.882% (1/17) 1 entry
ENSG00000062822 cecum adenocarcinoma conservative_inframe_deletion 4.528% (12/265) 1 entry
ENSG00000062822 small intestinal adenocarcinoma missense_variant 4.762% (1/21) 1 entry
ENSG00000062822 Gastric Diffuse Large B-Cell Lymphoma missense_variant 50.0% (1/2) 1 entry
ENSG00000062822 small cell lung carcinoma sequence_alteration 1.357% (6/442) 1 entry
ENSG00000062822 endometrium adenocarcinoma missense_variant 3.571% (1/28) 1 entry
ENSG00000062822 breast ductal adenocarcinoma missense_variant 1.319% (22/1668) 1 entry
ENSG00000062822 anaplastic astrocytoma missense_variant 1.449% (2/138) 1 entry
ENSG00000062822 nasopharyngeal squamous cell carcinoma missense_variant 0.5556% (1/180) 1 entry
ENSG00000062822 colorectal adenoma missense_variant 7.692% (1/13) 1 entry
ENSG00000062822 Duodenal Adenocarcinoma missense_variant 5.882% (1/17) 1 entry
ENSG00000062822 cecum adenocarcinoma frameshift_variant 4.528% (12/265) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000062822 SARC 0.0022 high
ENSG00000062822 STAD 0.017 low
ENSG00000062822 HNSC 0.0019 low
ENSG00000062822 KIRP 0.0038 high
ENSG00000062822 LUAD 0.0052 high
ENSG00000062822 PCPG 0.0025 high
ENSG00000062822 THYM 0.015 low
ENSG00000062822 PRAD 0.031 high
ENSG00000062822 BLCA 0.034 low
ENSG00000062822 LAML 0.0096 high
ENSG00000062822 SKCM 0.013 high
ENSG00000062822 CESC 0.0072 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000062822 LUSC Del 4.767274 0.110858 0.368535 0.271457
ENSG00000062822 LUAD Del 2.387901 0.071128 0.319372 0.358527
ENSG00000062822 LGG Del 18.688266 0.146886 0.663124 0.512671
ENSG00000062822 CESC Del 0.636873 0.065326 0.411830 0.118644
ENSG00000062822 SARC Del 2.696564 0.172718 0.428533 0.322957
ENSG00000062822 GBM Del 11.653226 0.135097 0.523525 0.162912
ENSG00000062822 PAAD Del 0.715144 0.045307 0.291729 0.114130
ENSG00000062822 DLBC Amp 1.244370 0.241046 0.601497 0.208333
ENSG00000062822 UCEC Del 1.089441 0.053028 0.462008 0.115028
ENSG00000062822 OV Del 12.897483 0.326291 0.566581 0.504318