Ensembl ID ENSG00000059573 Gene ID 5832 Accession 9722
Gene Symbol ALDH18A1 Alias GSAS;P5CS;PYCS;SPG9;ADCL3;SPG9A;SPG9B;ARCL3A Full Name aldehyde dehydrogenase 18 family member A1
Position 10 : 95605941 - 95656711 Length 50771 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene. [provided by RefSeq, Jul 2008]

ENSG00000059573 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000059573 ALDH18A1 1.03 3.28e-83 BRCA
ENSG00000059573 ALDH18A1 1.26 3.69e-77 LUSC
ENSG00000059573 ALDH18A1 1.37 9.03e-39 UCEC
ENSG00000059573 ALDH18A1 1.60 2.06e-92 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000059573 ALDH18A1 colorectal cancer 18401542
ENSG00000059573 ALDH18A1 tumors 22136381
ENSG00000059573 ALDH18A1 tumor 25881247
ENSG00000059573 ALDH18A1 tumor 26082174
ENSG00000059573 ALDH18A1 Cancer 27511626
ENSG00000059573 ALDH18A1 COAD 29116024
ENSG00000059573 ALDH18A1 tumours 29169183
ENSG00000059573 ALDH18A1 tumors 31088535
ENSG00000059573 ALDH18A1 tumor 31592410
ENSG00000059573 ALDH18A1 liver cancer 31726117
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000059573 ALDH18A1 MESO 0.00024 high
ENSG00000059573 ALDH18A1 SARC 0.0012 high
ENSG00000059573 ALDH18A1 STAD 0.00095 low
ENSG00000059573 ALDH18A1 UVM 0.0018 low
ENSG00000059573 ALDH18A1 UCEC 0.00063 low
ENSG00000059573 ALDH18A1 LUSC 0.0075 low
ENSG00000059573 ALDH18A1 KIRP 4e-04 high
ENSG00000059573 ALDH18A1 KICH 0.033 high
ENSG00000059573 ALDH18A1 LUAD 0.0015 high
ENSG00000059573 ALDH18A1 BRCA 0.034 high
ENSG00000059573 ALDH18A1 COAD 0.004 high
ENSG00000059573 ALDH18A1 UCS 0.046 low
ENSG00000059573 ALDH18A1 PRAD 0.023 high
ENSG00000059573 ALDH18A1 GBM 0.023 low
ENSG00000059573 ALDH18A1 SKCM 0.031 high
ENSG00000059573 ALDH18A1 CESC 0.0093 high
ENSG00000059573 ALDH18A1 LIHC 0.0049 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000059573 ALDH18A1 LUSC Del 1.328379 0.074770 0.361188 0.522954
ENSG00000059573 ALDH18A1 COAD Del 8.807989 0.105864 0.404128 0.232816
ENSG00000059573 ALDH18A1 GBM Del 0.920106 0.054789 0.694810 0.887348
ENSG00000059573 ALDH18A1 HNSC Del 1.038641 0.058488 0.341258 0.256705
ENSG00000059573 ALDH18A1 BLCA Del 1.808361 0.095528 0.396408 0.414216
ENSG00000059573 ALDH18A1 BRCA Del 2.132987 0.075585 0.370367 0.287963
ENSG00000059573 ALDH18A1 STAD Del 3.715939 0.096972 0.378301 0.240363
ENSG00000059573 ALDH18A1 PRAD Del 5.018221 0.115307 0.446209 0.176829
ENSG00000059573 ALDH18A1 UCEC Del 7.067655 0.102239 0.543269 0.146568
ENSG00000059573 ALDH18A1 MESO Del 2.016736 0.177953 0.494049 0.333333
ENSG00000059573 ALDH18A1 OV Del 11.087997 0.310023 0.554000 0.411054