Ensembl ID ENSG00000051596 Gene ID 84321 Accession 19072
Gene Symbol THOC3 Alias THO3;hTREX45 Full Name THO complex subunit 3
Position 5 : 175917873 - 176034680 Length 116808 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, May 2013]

ENSG00000051596 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000051596 THOC3 1.00 3.75e-51 BRCA
ENSG00000051596 THOC3 0.85 6.58e-19 COAD
ENSG00000051596 THOC3 2.33 1.25e-80 LUSC
ENSG00000051596 THOC3 1.22 1.26e-18 UCEC
ENSG00000051596 THOC3 0.96 5.09e-22 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000051596 THOC3 UVM 0.0058 high
ENSG00000051596 THOC3 UCEC 0.0059 high
ENSG00000051596 THOC3 THCA 0.032 low
ENSG00000051596 THOC3 ACC 0.044 low
ENSG00000051596 THOC3 LGG 0.0029 high
ENSG00000051596 THOC3 LUSC 0.025 low
ENSG00000051596 THOC3 HNSC 0.026 high
ENSG00000051596 THOC3 READ 0.0056 low
ENSG00000051596 THOC3 KICH 0.004 high
ENSG00000051596 THOC3 LUAD 0.02 high
ENSG00000051596 THOC3 PCPG 0.00045 low
ENSG00000051596 THOC3 THYM 0.05 low
ENSG00000051596 THOC3 COAD 0.036 low
ENSG00000051596 THOC3 UCS 0.034 high
ENSG00000051596 THOC3 OV 0.011 low
ENSG00000051596 THOC3 LIHC 0.0026 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000051596 THOC3 LGG Del 3.738853 0.066267 0.412002 0.113060
ENSG00000051596 THOC3 KIRP Amp 0.755584 0.054844 0.615206 0.125000
ENSG00000051596 THOC3 ACC Amp 1.656823 0.432994 1.252293 0.688889
ENSG00000051596 THOC3 SKCM Del 2.183848 0.089090 0.480611 0.302452
ENSG00000051596 THOC3 HNSC Del 0.691751 0.053925 0.387289 0.381226
ENSG00000051596 THOC3 LIHC Amp 1.183927 0.126380 0.540062 0.354054
ENSG00000051596 THOC3 BLCA Del 2.386998 0.103754 0.402556 0.490196
ENSG00000051596 THOC3 KIRC Amp 59.407579 0.324820 0.551063 0.626894