Ensembl ID ENSG00000051341 Gene ID 10721 Accession 9186
Gene Symbol POLQ Alias PRO0327 Full Name DNA polymerase theta
Position 3 : 121431431 - 121545988 Length 114558 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary Enables catalytic activity, acting on DNA; chromatin binding activity; and identical protein binding activity. Involved in DNA repair; negative regulation of double-strand break repair via homologous recombination; and protein homooligomerization. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ENSG00000051341 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000051341 POLQ 2.14 2.29e-50 KIRC
ENSG00000051341 POLQ 1.47 8.75e-26 HNSC
ENSG00000051341 POLQ 2.31 3.33e-24 BLCA
ENSG00000051341 POLQ 2.61 9.76e-125 BRCA
ENSG00000051341 POLQ 1.44 2.14e-28 COAD
ENSG00000051341 POLQ 2.49 1.96e-13 KICH
ENSG00000051341 POLQ 4.48 5.59e-246 LUSC
ENSG00000051341 POLQ 3.22 1.33e-14 GBM
ENSG00000051341 POLQ 2.56 2.72e-27 KIRP
ENSG00000051341 POLQ 2.99 1.68e-50 LIHC
ENSG00000051341 POLQ 1.90 4.94e-24 STAD
ENSG00000051341 POLQ 3.30 1.36e-75 UCEC
ENSG00000051341 POLQ 1.96 2.88e-13 ESCA
ENSG00000051341 POLQ 3.63 1.20e-14 CHOL
ENSG00000051341 POLQ 6.29 4.70e-47 CESC
ENSG00000051341 POLQ 3.29 4.07e-82 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000051341 POLQ cancers 14735462
ENSG00000051341 POLQ breast cancer 20624954
ENSG00000051341 POLQ tumour 20700469
ENSG00000051341 POLQ tumor 30099721
ENSG00000051341 POLQ papillary thyroid cancer 31439400
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000051341 POLQ basal cell carcinoma sequence_alteration 18.97% (11/58) 1 entry
ENSG00000051341 POLQ colorectal adenocarcinoma sequence_alteration 6.942% (79/1138) 2 entries
ENSG00000051341 POLQ breast ductal adenocarcinoma missense_variant 9.589% (56/584) 1 entry
ENSG00000051341 POLQ colorectal adenocarcinoma frameshift_variant 6.942% (79/1138) 2 entries
ENSG00000051341 POLQ colorectal adenocarcinoma stop_gained 6.942% (79/1138) 1 entry
ENSG00000051341 POLQ basal cell carcinoma missense_variant 18.97% (11/58) 1 entry
ENSG00000051341 POLQ lung adenocarcinoma missense_variant 5.074% (62/1222) 7 entries
ENSG00000051341 POLQ breast ductal adenocarcinoma sequence_alteration 9.589% (56/584) 2 entries
ENSG00000051341 POLQ lung adenocarcinoma sequence_alteration 5.074% (62/1222) 3 entries
ENSG00000051341 POLQ colorectal adenocarcinoma missense_variant 6.942% (79/1138) 4 entries
ENSG00000051341 POLQ HER2 Positive Breast Carcinoma missense_variant 10.13% (16/158) 2 entries
ENSG00000051341 POLQ lung adenocarcinoma stop_gained 5.074% (62/1222) 2 entries
ENSG00000051341 POLQ colon adenocarcinoma stop_gained 5.263% (38/722) 3 entries
ENSG00000051341 POLQ Gallbladder Adenocarcinoma missense_variant 4.274% (5/117) 2 entries
ENSG00000051341 POLQ head and neck squamous cell carcinoma stop_gained 1.072% (8/746) 1 entry
ENSG00000051341 POLQ female breast carcinoma missense_variant 2.046% (8/391) 1 entry
ENSG00000051341 POLQ cecum adenocarcinoma frameshift_variant 7.2% (9/125) 1 entry
ENSG00000051341 POLQ nasopharyngeal squamous cell carcinoma missense_variant 1.796% (3/167) 1 entry
ENSG00000051341 POLQ skin melanoma sequence_alteration 4.86% (47/967) 1 entry
ENSG00000051341 POLQ oral squamous cell carcinoma frameshift_variant 5.213% (11/211) 1 entry
ENSG00000051341 POLQ ovarian serous adenocarcinoma missense_variant 0.5944% (4/673) 2 entries
ENSG00000051341 POLQ acute myeloid leukemia missense_variant 1.103% (10/907) 1 entry
ENSG00000051341 POLQ prostate carcinoma missense_variant 2.273% (11/484) 2 entries
ENSG00000051341 POLQ colon adenocarcinoma frameshift_variant 5.263% (38/722) 3 entries
ENSG00000051341 POLQ esophageal adenocarcinoma missense_variant 4.795% (21/438) 1 entry
ENSG00000051341 POLQ oral squamous cell carcinoma stop_gained 5.213% (11/211) 2 entries
ENSG00000051341 POLQ lung adenocarcinoma conservative_inframe_deletion 5.074% (62/1222) 1 entry
ENSG00000051341 POLQ squamous cell lung carcinoma sequence_alteration 3.152% (26/825) 1 entry
ENSG00000051341 POLQ gastric intestinal type adenocarcinoma missense_variant 3.529% (3/85) 2 entries
ENSG00000051341 POLQ gastric adenocarcinoma sequence_alteration 4.48% (25/558) 1 entry
ENSG00000051341 POLQ squamous cell lung carcinoma stop_gained 3.152% (26/825) 2 entries
ENSG00000051341 POLQ brain glioblastoma missense_variant 0.54% (5/926) 1 entry
ENSG00000051341 POLQ melanoma missense_variant 8.911% (9/101) 3 entries
ENSG00000051341 POLQ esophageal squamous cell carcinoma missense_variant 2.219% (15/676) 6 entries
ENSG00000051341 POLQ head and neck squamous cell carcinoma sequence_alteration 1.072% (8/746) 1 entry
ENSG00000051341 POLQ rectal adenocarcinoma missense_variant 1.81% (4/221) 2 entries
ENSG00000051341 POLQ hairy cell leukemia missense_variant 9.524% (2/21) 1 entry
ENSG00000051341 POLQ large cell lung carcinoma missense_variant 22.22% (4/18) 1 entry
ENSG00000051341 POLQ head and neck squamous cell carcinoma missense_variant 1.072% (8/746) 3 entries
ENSG00000051341 POLQ skin melanoma stop_gained 4.86% (47/967) 3 entries
ENSG00000051341 POLQ skin melanoma missense_variant 4.86% (47/967) 4 entries
ENSG00000051341 POLQ small cell lung carcinoma missense_variant 4.012% (13/324) 4 entries
ENSG00000051341 POLQ clear cell renal carcinoma missense_variant 0.7752% (10/1290) 1 entry
ENSG00000051341 POLQ bile duct adenocarcinoma conservative_inframe_deletion 1.176% (5/425) 1 entry
ENSG00000051341 POLQ squamous cell lung carcinoma missense_variant 3.152% (26/825) 3 entries
ENSG00000051341 POLQ colon adenocarcinoma missense_variant 5.263% (38/722) 6 entries
ENSG00000051341 POLQ prostate carcinoma sequence_alteration 2.273% (11/484) 2 entries
ENSG00000051341 POLQ bile duct adenocarcinoma missense_variant 1.176% (5/425) 1 entry
ENSG00000051341 POLQ breast carcinoma stop_gained 1.205% (17/1411) 1 entry
ENSG00000051341 POLQ hepatocellular carcinoma missense_variant 2.109% (19/901) 2 entries
ENSG00000051341 POLQ breast carcinoma missense_variant 1.205% (17/1411) 2 entries
ENSG00000051341 POLQ colon adenocarcinoma sequence_alteration 5.263% (38/722) 3 entries
ENSG00000051341 POLQ cecum adenocarcinoma missense_variant 7.2% (9/125) 1 entry
ENSG00000051341 POLQ oral squamous cell carcinoma missense_variant 5.213% (11/211) 3 entries
ENSG00000051341 POLQ diffuse gastric adenocarcinoma sequence_alteration 2.532% (2/79) 1 entry
ENSG00000051341 POLQ brain glioblastoma frameshift_variant 0.54% (5/926) 1 entry
ENSG00000051341 POLQ angiosarcoma sequence_alteration 7.692% (1/13) 1 entry
ENSG00000051341 POLQ Malignant Germ Cell Tumor missense_variant 100.0% (1/1) 1 entry
ENSG00000051341 POLQ multiple myeloma missense_variant 2.273% (1/44) 1 entry
ENSG00000051341 POLQ diffuse gastric adenocarcinoma stop_gained 2.532% (2/79) 1 entry
ENSG00000051341 POLQ breast phyllodes tumor missense_variant 4.545% (1/22) 1 entry
ENSG00000051341 POLQ central nervous system primitive neuroectodermal neoplasm stop_gained 0.4505% (2/444) 1 entry
ENSG00000051341 POLQ bile duct adenocarcinoma frameshift_variant 1.176% (5/425) 1 entry
ENSG00000051341 POLQ gastric intestinal type adenocarcinoma frameshift_variant 3.529% (3/85) 1 entry
ENSG00000051341 POLQ esophageal squamous cell carcinoma sequence_alteration 2.219% (15/676) 1 entry
ENSG00000051341 POLQ Gallbladder Adenocarcinoma sequence_alteration 4.274% (5/117) 1 entry
ENSG00000051341 POLQ clear cell renal carcinoma frameshift_variant 0.7752% (10/1290) 1 entry
ENSG00000051341 POLQ clear cell renal carcinoma conservative_inframe_deletion 0.7752% (10/1290) 1 entry
ENSG00000051341 POLQ Extraskeletal Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor missense_variant 3.704% (1/27) 1 entry
ENSG00000051341 POLQ Merkel cell skin cancer missense_variant 3.333% (1/30) 1 entry
ENSG00000051341 POLQ laryngeal squamous cell carcinoma missense_variant 3.846% (1/26) 1 entry
ENSG00000051341 POLQ pancreatic ductal adenocarcinoma frameshift_variant 3.495% (44/1259) 1 entry
ENSG00000051341 POLQ neoplasm missense_variant 7.143% (2/28) 1 entry
ENSG00000051341 POLQ large cell lung carcinoma sequence_alteration 22.22% (4/18) 1 entry
ENSG00000051341 POLQ Pancreatic Acinar Cell Carcinoma missense_variant 5.0% (1/20) 1 entry
ENSG00000051341 POLQ hepatocellular carcinoma stop_gained 2.109% (19/901) 1 entry
ENSG00000051341 POLQ ovarian mucinous adenocarcinoma missense_variant 7.692% (1/13) 1 entry
ENSG00000051341 POLQ T-cell acute lymphoblastic leukemia missense_variant 0.2632% (1/380) 1 entry
ENSG00000051341 POLQ blood vessel neoplasm missense_variant 16.67% (1/6) 1 entry
ENSG00000051341 POLQ non-small cell lung carcinoma conservative_inframe_deletion 3.226% (2/62) 1 entry
ENSG00000051341 POLQ colon carcinoma stop_gained 25.0% (2/8) 1 entry
ENSG00000051341 POLQ non-small cell lung carcinoma missense_variant 3.226% (2/62) 1 entry
ENSG00000051341 POLQ small cell lung carcinoma frameshift_variant 4.012% (13/324) 1 entry
ENSG00000051341 POLQ chronic myelomonocytic leukemia missense_variant 3.704% (1/27) 1 entry
ENSG00000051341 POLQ adrenal cortex carcinoma missense_variant 0.6098% (1/164) 1 entry
ENSG00000051341 POLQ mucosal melanoma missense_variant 7.143% (1/14) 1 entry
ENSG00000051341 POLQ bile duct adenocarcinoma stop_gained 1.176% (5/425) 1 entry
ENSG00000051341 POLQ colonic neoplasm missense_variant 6.667% (1/15) 1 entry
ENSG00000051341 POLQ melanoma conservative_inframe_deletion 8.911% (9/101) 1 entry
ENSG00000051341 POLQ ependymoma sequence_alteration 2.174% (1/46) 1 entry
ENSG00000051341 POLQ colon carcinoma missense_variant 25.0% (2/8) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000051341 POLQ SARC 0.0096 high
ENSG00000051341 POLQ STAD 0.00012 low
ENSG00000051341 POLQ CHOL 0.015 high
ENSG00000051341 POLQ UVM 0.041 high
ENSG00000051341 POLQ THCA 0.00088 high
ENSG00000051341 POLQ LUSC 0.031 low
ENSG00000051341 POLQ HNSC 0.004 low
ENSG00000051341 POLQ READ 0.013 low
ENSG00000051341 POLQ LUAD 0.00085 high
ENSG00000051341 POLQ PCPG 0.0072 high
ENSG00000051341 POLQ THYM 0.0013 low
ENSG00000051341 POLQ ESCA 0.034 high
ENSG00000051341 POLQ PRAD 0.015 high
ENSG00000051341 POLQ SKCM 0.012 low
ENSG00000051341 POLQ CESC 0.015 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000051341 POLQ GBM Del 1.646813 0.063608 0.496975 0.100520