Ensembl ID ENSG00000051341 Gene ID 10721 Accession 9186
Gene Symbol POLQ Alias PRO0327 Full Name DNA polymerase theta
Position 3 : 121431431 - 121545988 Length 114558 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary Enables catalytic activity, acting on DNA; chromatin binding activity; and identical protein binding activity. Involved in DNA repair; negative regulation of double-strand break repair via homologous recombination; and protein homooligomerization. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ENSG00000051341 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000051341 2.14 2.29e-50 KIRC
ENSG00000051341 1.47 8.75e-26 HNSC
ENSG00000051341 2.31 3.33e-24 BLCA
ENSG00000051341 2.61 9.76e-125 BRCA
ENSG00000051341 1.44 2.14e-28 COAD
ENSG00000051341 2.49 1.96e-13 KICH
ENSG00000051341 4.48 5.59e-246 LUSC
ENSG00000051341 3.22 1.33e-14 GBM
ENSG00000051341 2.56 2.72e-27 KIRP
ENSG00000051341 2.99 1.68e-50 LIHC
ENSG00000051341 1.90 4.94e-24 STAD
ENSG00000051341 3.30 1.36e-75 UCEC
ENSG00000051341 1.96 2.88e-13 ESCA
ENSG00000051341 3.63 1.20e-14 CHOL
ENSG00000051341 6.29 4.70e-47 CESC
ENSG00000051341 3.29 4.07e-82 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000051341 cancers 14735462
ENSG00000051341 breast cancer 20624954
ENSG00000051341 tumour 20700469
ENSG00000051341 tumor 30099721
ENSG00000051341 papillary thyroid cancer 31439400
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000051341 basal cell carcinoma sequence_alteration 18.97% (11/58) 1 entry
ENSG00000051341 colorectal adenocarcinoma sequence_alteration 6.942% (79/1138) 2 entries
ENSG00000051341 breast ductal adenocarcinoma missense_variant 9.589% (56/584) 1 entry
ENSG00000051341 colorectal adenocarcinoma frameshift_variant 6.942% (79/1138) 2 entries
ENSG00000051341 colorectal adenocarcinoma stop_gained 6.942% (79/1138) 1 entry
ENSG00000051341 basal cell carcinoma missense_variant 18.97% (11/58) 1 entry
ENSG00000051341 lung adenocarcinoma missense_variant 5.074% (62/1222) 7 entries
ENSG00000051341 breast ductal adenocarcinoma sequence_alteration 9.589% (56/584) 2 entries
ENSG00000051341 lung adenocarcinoma sequence_alteration 5.074% (62/1222) 3 entries
ENSG00000051341 colorectal adenocarcinoma missense_variant 6.942% (79/1138) 4 entries
ENSG00000051341 HER2 Positive Breast Carcinoma missense_variant 10.13% (16/158) 2 entries
ENSG00000051341 lung adenocarcinoma stop_gained 5.074% (62/1222) 2 entries
ENSG00000051341 colon adenocarcinoma stop_gained 5.263% (38/722) 3 entries
ENSG00000051341 Gallbladder Adenocarcinoma missense_variant 4.274% (5/117) 2 entries
ENSG00000051341 head and neck squamous cell carcinoma stop_gained 1.072% (8/746) 1 entry
ENSG00000051341 female breast carcinoma missense_variant 2.046% (8/391) 1 entry
ENSG00000051341 cecum adenocarcinoma frameshift_variant 7.2% (9/125) 1 entry
ENSG00000051341 nasopharyngeal squamous cell carcinoma missense_variant 1.796% (3/167) 1 entry
ENSG00000051341 skin melanoma sequence_alteration 4.86% (47/967) 1 entry
ENSG00000051341 oral squamous cell carcinoma frameshift_variant 5.213% (11/211) 1 entry
ENSG00000051341 ovarian serous adenocarcinoma missense_variant 0.5944% (4/673) 2 entries
ENSG00000051341 acute myeloid leukemia missense_variant 1.103% (10/907) 1 entry
ENSG00000051341 prostate carcinoma missense_variant 2.273% (11/484) 2 entries
ENSG00000051341 colon adenocarcinoma frameshift_variant 5.263% (38/722) 3 entries
ENSG00000051341 esophageal adenocarcinoma missense_variant 4.795% (21/438) 1 entry
ENSG00000051341 oral squamous cell carcinoma stop_gained 5.213% (11/211) 2 entries
ENSG00000051341 lung adenocarcinoma conservative_inframe_deletion 5.074% (62/1222) 1 entry
ENSG00000051341 squamous cell lung carcinoma sequence_alteration 3.152% (26/825) 1 entry
ENSG00000051341 gastric intestinal type adenocarcinoma missense_variant 3.529% (3/85) 2 entries
ENSG00000051341 gastric adenocarcinoma sequence_alteration 4.48% (25/558) 1 entry
ENSG00000051341 squamous cell lung carcinoma stop_gained 3.152% (26/825) 2 entries
ENSG00000051341 brain glioblastoma missense_variant 0.54% (5/926) 1 entry
ENSG00000051341 melanoma missense_variant 8.911% (9/101) 3 entries
ENSG00000051341 esophageal squamous cell carcinoma missense_variant 2.219% (15/676) 6 entries
ENSG00000051341 head and neck squamous cell carcinoma sequence_alteration 1.072% (8/746) 1 entry
ENSG00000051341 rectal adenocarcinoma missense_variant 1.81% (4/221) 2 entries
ENSG00000051341 hairy cell leukemia missense_variant 9.524% (2/21) 1 entry
ENSG00000051341 large cell lung carcinoma missense_variant 22.22% (4/18) 1 entry
ENSG00000051341 head and neck squamous cell carcinoma missense_variant 1.072% (8/746) 3 entries
ENSG00000051341 skin melanoma stop_gained 4.86% (47/967) 3 entries
ENSG00000051341 skin melanoma missense_variant 4.86% (47/967) 4 entries
ENSG00000051341 small cell lung carcinoma missense_variant 4.012% (13/324) 4 entries
ENSG00000051341 clear cell renal carcinoma missense_variant 0.7752% (10/1290) 1 entry
ENSG00000051341 bile duct adenocarcinoma conservative_inframe_deletion 1.176% (5/425) 1 entry
ENSG00000051341 squamous cell lung carcinoma missense_variant 3.152% (26/825) 3 entries
ENSG00000051341 colon adenocarcinoma missense_variant 5.263% (38/722) 6 entries
ENSG00000051341 prostate carcinoma sequence_alteration 2.273% (11/484) 2 entries
ENSG00000051341 bile duct adenocarcinoma missense_variant 1.176% (5/425) 1 entry
ENSG00000051341 breast carcinoma stop_gained 1.205% (17/1411) 1 entry
ENSG00000051341 hepatocellular carcinoma missense_variant 2.109% (19/901) 2 entries
ENSG00000051341 breast carcinoma missense_variant 1.205% (17/1411) 2 entries
ENSG00000051341 colon adenocarcinoma sequence_alteration 5.263% (38/722) 3 entries
ENSG00000051341 cecum adenocarcinoma missense_variant 7.2% (9/125) 1 entry
ENSG00000051341 oral squamous cell carcinoma missense_variant 5.213% (11/211) 3 entries
ENSG00000051341 diffuse gastric adenocarcinoma sequence_alteration 2.532% (2/79) 1 entry
ENSG00000051341 brain glioblastoma frameshift_variant 0.54% (5/926) 1 entry
ENSG00000051341 angiosarcoma sequence_alteration 7.692% (1/13) 1 entry
ENSG00000051341 Malignant Germ Cell Tumor missense_variant 100.0% (1/1) 1 entry
ENSG00000051341 multiple myeloma missense_variant 2.273% (1/44) 1 entry
ENSG00000051341 diffuse gastric adenocarcinoma stop_gained 2.532% (2/79) 1 entry
ENSG00000051341 breast phyllodes tumor missense_variant 4.545% (1/22) 1 entry
ENSG00000051341 central nervous system primitive neuroectodermal neoplasm stop_gained 0.4505% (2/444) 1 entry
ENSG00000051341 bile duct adenocarcinoma frameshift_variant 1.176% (5/425) 1 entry
ENSG00000051341 gastric intestinal type adenocarcinoma frameshift_variant 3.529% (3/85) 1 entry
ENSG00000051341 esophageal squamous cell carcinoma sequence_alteration 2.219% (15/676) 1 entry
ENSG00000051341 Gallbladder Adenocarcinoma sequence_alteration 4.274% (5/117) 1 entry
ENSG00000051341 clear cell renal carcinoma frameshift_variant 0.7752% (10/1290) 1 entry
ENSG00000051341 clear cell renal carcinoma conservative_inframe_deletion 0.7752% (10/1290) 1 entry
ENSG00000051341 Extraskeletal Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor missense_variant 3.704% (1/27) 1 entry
ENSG00000051341 Merkel cell skin cancer missense_variant 3.333% (1/30) 1 entry
ENSG00000051341 laryngeal squamous cell carcinoma missense_variant 3.846% (1/26) 1 entry
ENSG00000051341 pancreatic ductal adenocarcinoma frameshift_variant 3.495% (44/1259) 1 entry
ENSG00000051341 neoplasm missense_variant 7.143% (2/28) 1 entry
ENSG00000051341 large cell lung carcinoma sequence_alteration 22.22% (4/18) 1 entry
ENSG00000051341 Pancreatic Acinar Cell Carcinoma missense_variant 5.0% (1/20) 1 entry
ENSG00000051341 hepatocellular carcinoma stop_gained 2.109% (19/901) 1 entry
ENSG00000051341 ovarian mucinous adenocarcinoma missense_variant 7.692% (1/13) 1 entry
ENSG00000051341 T-cell acute lymphoblastic leukemia missense_variant 0.2632% (1/380) 1 entry
ENSG00000051341 blood vessel neoplasm missense_variant 16.67% (1/6) 1 entry
ENSG00000051341 non-small cell lung carcinoma conservative_inframe_deletion 3.226% (2/62) 1 entry
ENSG00000051341 colon carcinoma stop_gained 25.0% (2/8) 1 entry
ENSG00000051341 non-small cell lung carcinoma missense_variant 3.226% (2/62) 1 entry
ENSG00000051341 small cell lung carcinoma frameshift_variant 4.012% (13/324) 1 entry
ENSG00000051341 chronic myelomonocytic leukemia missense_variant 3.704% (1/27) 1 entry
ENSG00000051341 adrenal cortex carcinoma missense_variant 0.6098% (1/164) 1 entry
ENSG00000051341 mucosal melanoma missense_variant 7.143% (1/14) 1 entry
ENSG00000051341 bile duct adenocarcinoma stop_gained 1.176% (5/425) 1 entry
ENSG00000051341 colonic neoplasm missense_variant 6.667% (1/15) 1 entry
ENSG00000051341 melanoma conservative_inframe_deletion 8.911% (9/101) 1 entry
ENSG00000051341 ependymoma sequence_alteration 2.174% (1/46) 1 entry
ENSG00000051341 colon carcinoma missense_variant 25.0% (2/8) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000051341 SARC 0.0096 high
ENSG00000051341 STAD 0.00012 low
ENSG00000051341 CHOL 0.015 high
ENSG00000051341 UVM 0.041 high
ENSG00000051341 THCA 0.00088 high
ENSG00000051341 LUSC 0.031 low
ENSG00000051341 HNSC 0.004 low
ENSG00000051341 READ 0.013 low
ENSG00000051341 LUAD 0.00085 high
ENSG00000051341 PCPG 0.0072 high
ENSG00000051341 THYM 0.0013 low
ENSG00000051341 ESCA 0.034 high
ENSG00000051341 PRAD 0.015 high
ENSG00000051341 SKCM 0.012 low
ENSG00000051341 CESC 0.015 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000051341 GBM Del 1.646813 0.063608 0.496975 0.100520