Ensembl ID ENSG00000047188 Gene ID 64848 Accession 24721
Gene Symbol YTHDC2 Alias CAHL;hYTHDC2 Full Name YTH N6-methyladenosine RNA binding protein C2
Position 5 : 113513694 - 113595284 Length 81591 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line. [provided by RefSeq, Sep 2016]

ENSG00000047188 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000047188 YTHDC2 0.40 1.89e-12 KIRC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000047188 YTHDC2 tumor 24269672
ENSG00000047188 YTHDC2 cancer 24834797
ENSG00000047188 YTHDC2 cancer 26996300
ENSG00000047188 YTHDC2 colon cancer 30062093
ENSG00000047188 YTHDC2 gastric cancer 31681576
ENSG00000047188 YTHDC2 tumor 31720080
ENSG00000047188 YTHDC2 tumors 31823961
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000047188 YTHDC2 MESO 0.025 low
ENSG00000047188 YTHDC2 PAAD 0.042 low
ENSG00000047188 YTHDC2 UCEC 0.0082 low
ENSG00000047188 YTHDC2 THCA 0.024 high
ENSG00000047188 YTHDC2 LGG 0.0011 high
ENSG00000047188 YTHDC2 HNSC 0.00062 low
ENSG00000047188 YTHDC2 KICH 0.015 high
ENSG00000047188 YTHDC2 LUAD 0.0096 low
ENSG00000047188 YTHDC2 COAD 7e-04 low
ENSG00000047188 YTHDC2 UCS 0.046 high
ENSG00000047188 YTHDC2 OV 0.0087 high
ENSG00000047188 YTHDC2 KIRC 0.0024 low
ENSG00000047188 YTHDC2 PRAD 0.036 high
ENSG00000047188 YTHDC2 BLCA 0.023 low
ENSG00000047188 YTHDC2 SKCM 0.004 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000047188 YTHDC2 LAML Del 5.991238 0.087859 0.793419 0.083770
ENSG00000047188 YTHDC2 LUAD Del 3.205564 0.078681 0.342640 0.399225
ENSG00000047188 YTHDC2 ACC Amp 0.881753 0.269100 1.270737 0.666667
ENSG00000047188 YTHDC2 READ Del 2.280112 0.109577 0.454998 0.333333
ENSG00000047188 YTHDC2 COAD Del 13.823192 0.134431 0.445580 0.286031
ENSG00000047188 YTHDC2 STAD Del 7.297078 0.127168 0.401121 0.369615
ENSG00000047188 YTHDC2 PRAD Del 6.296193 0.124769 0.533393 0.134146
ENSG00000047188 YTHDC2 KIRC Amp 26.932513 0.192082 0.520789 0.535985
ENSG00000047188 YTHDC2 OV Del 16.785025 0.358079 0.616876 0.556131