Ensembl ID ENSG00000044115 Gene ID 1495 Accession 2509
Gene Symbol CTNNA1 Alias MDBS2;MDPT2;CAP102 Full Name catenin alpha 1
Position 5 : 138610967 - 138935034 Length 324068 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016]

ENSG00000044115 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000044115 -0.6 1.39e-18 HNSC
ENSG00000044115 -0.4 3.92e-11 COAD
ENSG00000044115 -0.6 3.19e-23 LUSC
ENSG00000044115 0.45 9.48e-13 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000044115 colon cancer 10023666
ENSG00000044115 tumor 10542129
ENSG00000044115 colon cancer 10692769
ENSG00000044115 colon cancer 10919711
ENSG00000044115 tumors 11813884
ENSG00000044115 cancer 11997091
ENSG00000044115 colorectal cancer 12485498
ENSG00000044115 cancer 14580768
ENSG00000044115 colon cancer 14961074
ENSG00000044115 ovarian tumors 15297182
ENSG00000044115 tumor 16038265
ENSG00000044115 tumor 16304374
ENSG00000044115 tumor 18190825
ENSG00000044115 tumor 19375852
ENSG00000044115 AML 19826047
ENSG00000044115 tumor 20371743
ENSG00000044115 tumor 20393555
ENSG00000044115 AML 20671427
ENSG00000044115 tumor 21274003
ENSG00000044115 lung cancer 23122428
ENSG00000044115 hereditary diffuse gastric cancer 23208944
ENSG00000044115 colorectal cancer 23399619
ENSG00000044115 breast tumors 24509793
ENSG00000044115 Tumor 24552534
ENSG00000044115 tumor 24670416
ENSG00000044115 cancers 24685333
ENSG00000044115 tumor 24858105
ENSG00000044115 tumor 25153418
ENSG00000044115 gastric cancer 25439071
ENSG00000044115 tumors 25469175
ENSG00000044115 gastric cancer 25576241
ENSG00000044115 cancer 25625225
ENSG00000044115 tumor 26182300
ENSG00000044115 tumors 26257336
ENSG00000044115 tumor 26597461
ENSG00000044115 cancers 26882563
ENSG00000044115 acute myeloid leukemia (AML) 27129146
ENSG00000044115 tumours 27161491
ENSG00000044115 colorectal cancer 27487124
ENSG00000044115 gastric cancer 27899187
ENSG00000044115 tumors 28186973
ENSG00000044115 breast cancer 28345629
ENSG00000044115 ovarian cancer 28881822
ENSG00000044115 tumor 29032073
ENSG00000044115 gastric cancer 29330337
ENSG00000044115 cancer 29774524
ENSG00000044115 hereditary diffuse gastric cancer 30515673
ENSG00000044115 tumor 31269666
ENSG00000044115 tumor 31442208
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000044115 MESO 0.05 low
ENSG00000044115 SARC 0.023 low
ENSG00000044115 PAAD 0.00039 high
ENSG00000044115 UCEC 0.035 low
ENSG00000044115 ACC 0.045 low
ENSG00000044115 READ 0.014 low
ENSG00000044115 KIRP 0.019 low
ENSG00000044115 KICH 0.011 high
ENSG00000044115 LUAD 0.0091 high
ENSG00000044115 PCPG 0.035 high
ENSG00000044115 THYM 0.015 high
ENSG00000044115 BRCA 0.0096 high
ENSG00000044115 PRAD 0.042 low
ENSG00000044115 GBM 0.027 low
ENSG00000044115 SKCM 0.025 high
ENSG00000044115 CESC 0.02 high
ENSG00000044115 LIHC 0.0026 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000044115 LAML Del 6.887040 0.098062 0.800560 0.089005
ENSG00000044115 LGG Del 1.584660 0.048540 0.386406 0.089669
ENSG00000044115 ACC Amp 0.739414 0.250485 1.227925 0.666667
ENSG00000044115 SKCM Del 5.370485 0.125965 0.499957 0.332425
ENSG00000044115 PCPG Del 0.645217 0.056137 0.664776 0.074074
ENSG00000044115 KIRC Amp 49.187013 0.284865 0.540515 0.607955