Ensembl ID ENSG00000037897 Gene ID 4234 Accession 7030
Gene Symbol METTL1 Alias TRM8;TRMT8;C12orf1;YDL201w Full Name methyltransferase 1, tRNA methylguanosine
Position 12 : 57768471 - 57772119 Length 3649 bases Strand Minus strand
Status Confidence Main interacting RNAstRNARBP type Non-canonical_RBPs
Summary This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]

ENSG00000037897 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000037897 METTL1 0.86 8.78e-37 BRCA
ENSG00000037897 METTL1 1.37 2.40e-50 COAD
ENSG00000037897 METTL1 1.31 9.66e-18 READ
ENSG00000037897 METTL1 1.22 4.08e-40 LUSC
ENSG00000037897 METTL1 0.59 2.19e-14 PRAD
ENSG00000037897 METTL1 0.91 1.33e-12 STAD
ENSG00000037897 METTL1 1.37 1.18e-33 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000037897 METTL1 cancer 25233213
ENSG00000037897 METTL1 GBM 25653168
ENSG00000037897 METTL1 GBM 27899621
ENSG00000037897 METTL1 lung cancer 31031083
ENSG00000037897 METTL1 tumor 31463732
ENSG00000037897 METTL1 colon cancer 31866582
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000037897 METTL1 MESO 0.00036 high
ENSG00000037897 METTL1 SARC 0.031 high
ENSG00000037897 METTL1 CHOL 0.0016 high
ENSG00000037897 METTL1 UVM 0.012 high
ENSG00000037897 METTL1 UCEC 0.021 high
ENSG00000037897 METTL1 THCA 0.05 high
ENSG00000037897 METTL1 ACC 0.014 high
ENSG00000037897 METTL1 HNSC 0.013 high
ENSG00000037897 METTL1 READ 0.0039 high
ENSG00000037897 METTL1 KICH 0.042 high
ENSG00000037897 METTL1 LUAD 0.015 high
ENSG00000037897 METTL1 PCPG 0.016 low
ENSG00000037897 METTL1 THYM 0.042 low
ENSG00000037897 METTL1 COAD 0.044 low
ENSG00000037897 METTL1 ESCA 0.019 low
ENSG00000037897 METTL1 OV 0.0011 low
ENSG00000037897 METTL1 LAML 0.044 high
ENSG00000037897 METTL1 GBM 0.01 high
ENSG00000037897 METTL1 SKCM 0.0035 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000037897 METTL1 LUAD Amp 14.820003 0.337167 0.663913 0.327519
ENSG00000037897 METTL1 LGG Amp 33.878055 0.348348 2.144374 0.068226
ENSG00000037897 METTL1 ACC Amp 1.656823 0.437205 1.193666 0.777778
ENSG00000037897 METTL1 SARC Amp 58.856737 1.661765 2.380582 0.303502
ENSG00000037897 METTL1 GBM Amp 138.735978 1.168567 2.317580 0.223570
ENSG00000037897 METTL1 SKCM Amp 8.102763 0.318205 1.028408 0.155313
ENSG00000037897 METTL1 PCPG Amp 0.764816 0.071409 0.638335 0.098765
ENSG00000037897 METTL1 STAD Amp 2.227534 0.175647 0.581506 0.217687