Ensembl ID
ENSG00000037897
Gene ID
4234
Accession
7030
Gene Symbol
METTL1
Alias
TRM8;TRMT8;C12orf1;YDL201w
Full Name
methyltransferase 1, tRNA methylguanosine
Position
12 : 57768471 - 57772119
Length
3649 bases
Strand
Minus strand
Status
Confidence
Main interacting RNAs tRNA RBP type
Non-canonical_RBPs
Summary
This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]
ENSG00000037897 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000037897
METTL1
0.86
8.78e-37
BRCA
ENSG00000037897
METTL1
1.37
2.40e-50
COAD
ENSG00000037897
METTL1
1.31
9.66e-18
READ
ENSG00000037897
METTL1
1.22
4.08e-40
LUSC
ENSG00000037897
METTL1
0.59
2.19e-14
PRAD
ENSG00000037897
METTL1
0.91
1.33e-12
STAD
ENSG00000037897
METTL1
1.37
1.18e-33
LUAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000037897
METTL1
cancer
25233213
ENSG00000037897
METTL1
GBM
25653168
ENSG00000037897
METTL1
GBM
27899621
ENSG00000037897
METTL1
lung cancer
31031083
ENSG00000037897
METTL1
tumor
31463732
ENSG00000037897
METTL1
colon cancer
31866582
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000037897
METTL1
MESO
0.00036
high
show
ENSG00000037897
METTL1
SARC
0.031
high
show
ENSG00000037897
METTL1
CHOL
0.0016
high
show
ENSG00000037897
METTL1
UVM
0.012
high
show
ENSG00000037897
METTL1
UCEC
0.021
high
show
ENSG00000037897
METTL1
THCA
0.05
high
show
ENSG00000037897
METTL1
ACC
0.014
high
show
ENSG00000037897
METTL1
HNSC
0.013
high
show
ENSG00000037897
METTL1
READ
0.0039
high
show
ENSG00000037897
METTL1
KICH
0.042
high
show
ENSG00000037897
METTL1
LUAD
0.015
high
show
ENSG00000037897
METTL1
PCPG
0.016
low
show
ENSG00000037897
METTL1
THYM
0.042
low
show
ENSG00000037897
METTL1
COAD
0.044
low
show
ENSG00000037897
METTL1
ESCA
0.019
low
show
ENSG00000037897
METTL1
OV
0.0011
low
show
ENSG00000037897
METTL1
LAML
0.044
high
show
ENSG00000037897
METTL1
GBM
0.01
high
show
ENSG00000037897
METTL1
SKCM
0.0035
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000037897
METTL1
LUAD
Amp
14.820003
0.337167
0.663913
0.327519
ENSG00000037897
METTL1
LGG
Amp
33.878055
0.348348
2.144374
0.068226
ENSG00000037897
METTL1
ACC
Amp
1.656823
0.437205
1.193666
0.777778
ENSG00000037897
METTL1
SARC
Amp
58.856737
1.661765
2.380582
0.303502
ENSG00000037897
METTL1
GBM
Amp
138.735978
1.168567
2.317580
0.223570
ENSG00000037897
METTL1
SKCM
Amp
8.102763
0.318205
1.028408
0.155313
ENSG00000037897
METTL1
PCPG
Amp
0.764816
0.071409
0.638335
0.098765
ENSG00000037897
METTL1
STAD
Amp
2.227534
0.175647
0.581506
0.217687
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