Ensembl ID ENSG00000037474 Gene ID 54888 Accession 25994
Gene Symbol NSUN2 Alias MISU;MRT5;SAKI;TRM4 Full Name NOP2/Sun RNA methyltransferase 2
Position 5 : 6599239 - 6633291 Length 34053 bases Strand Minus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011]

ENSG00000037474 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000037474 NSUN2 0.34 5.40e-16 KIRC
ENSG00000037474 NSUN2 0.44 1.96e-17 BRCA
ENSG00000037474 NSUN2 0.51 8.10e-19 COAD
ENSG00000037474 NSUN2 0.79 1.39e-20 KICH
ENSG00000037474 NSUN2 1.29 4.31e-47 LUSC
ENSG00000037474 NSUN2 0.37 9.10e-16 PRAD
ENSG00000037474 NSUN2 0.78 2.80e-14 STAD
ENSG00000037474 NSUN2 1.01 3.77e-33 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000037474 NSUN2 tumors 16713953
ENSG00000037474 NSUN2 breast cancer 19596847
ENSG00000037474 NSUN2 breast cancer 19740597
ENSG00000037474 NSUN2 cancers 22136356
ENSG00000037474 NSUN2 cancer 23604283
ENSG00000037474 NSUN2 cancer 23681756
ENSG00000037474 NSUN2 cancer 23851603
ENSG00000037474 NSUN2 cancer 25233213
ENSG00000037474 NSUN2 tumor 25692999
ENSG00000037474 NSUN2 breast cancer 27447970
ENSG00000037474 NSUN2 ovarian cancer 28829218
ENSG00000037474 NSUN2 tumor 29763634
ENSG00000037474 NSUN2 Wilms’ tumor 29900123
ENSG00000037474 NSUN2 cancers 30597914
ENSG00000037474 NSUN2 tumors 30816500
ENSG00000037474 NSUN2 HNSCC 30863149
ENSG00000037474 NSUN2 prostate cancer 30971929
ENSG00000037474 NSUN2 tumor 31487418
ENSG00000037474 NSUN2 tumor 31619685
ENSG00000037474 NSUN2 cancers 31957540
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000037474 NSUN2 MESO 0.04 high
ENSG00000037474 NSUN2 STAD 0.0022 low
ENSG00000037474 NSUN2 UVM 0.024 high
ENSG00000037474 NSUN2 PAAD 0.0047 high
ENSG00000037474 NSUN2 THCA 0.00083 high
ENSG00000037474 NSUN2 ACC 0.027 high
ENSG00000037474 NSUN2 LGG 0.0026 high
ENSG00000037474 NSUN2 HNSC 0.041 high
ENSG00000037474 NSUN2 KICH 0.0032 high
ENSG00000037474 NSUN2 PCPG 0.036 high
ENSG00000037474 NSUN2 BRCA 0.039 high
ENSG00000037474 NSUN2 COAD 0.013 high
ENSG00000037474 NSUN2 DLBC 0.029 low
ENSG00000037474 NSUN2 KIRC 0.0032 high
ENSG00000037474 NSUN2 PRAD 0.0099 low
ENSG00000037474 NSUN2 BLCA 0.0025 low
ENSG00000037474 NSUN2 LAML 0.028 high
ENSG00000037474 NSUN2 SKCM 0.00067 low
ENSG00000037474 NSUN2 CESC 0.05 high
ENSG00000037474 NSUN2 LIHC 0.0014 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000037474 NSUN2 LUSC Amp 11.991957 0.430478 0.856435 0.766467
ENSG00000037474 NSUN2 LUAD Amp 14.198030 0.329192 0.748489 0.631783
ENSG00000037474 NSUN2 LGG Del 1.554687 0.048329 0.489936 0.085770
ENSG00000037474 NSUN2 CESC Amp 2.236256 0.187078 0.958938 0.457627
ENSG00000037474 NSUN2 ACC Amp 1.155613 0.308112 1.316365 0.600000
ENSG00000037474 NSUN2 SKCM Amp 0.856007 0.124962 0.625418 0.245232
ENSG00000037474 NSUN2 HNSC Amp 0.662125 0.114388 0.647775 0.452107
ENSG00000037474 NSUN2 BLCA Amp 2.741053 0.231791 0.773727 0.507353
ENSG00000037474 NSUN2 UCEC Amp 1.058517 0.112304 0.776612 0.148423
ENSG00000037474 NSUN2 OV Amp 3.707209 0.421197 0.882761 0.506045