Ensembl ID ENSG00000035403 Gene ID 7414 Accession 12665
Gene Symbol VCL Alias MV;MVCL;CMD1W;CMH15;HEL114 Full Name vinculin
Position 10 : 73998114 - 74121363 Length 123250 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

ENSG00000035403 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000035403 -0.7 4.54e-23 KIRC
ENSG00000035403 -1.9 2.01e-24 BLCA
ENSG00000035403 -0.6 1.03e-24 BRCA
ENSG00000035403 -1.0 2.64e-22 COAD
ENSG00000035403 -0.9 1.59e-13 KICH
ENSG00000035403 -1.4 3.48e-15 READ
ENSG00000035403 -1.4 3.79e-29 PRAD
ENSG00000035403 -0.8 2.18e-12 KIRP
ENSG00000035403 -1.3 1.88e-27 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000035403 Malignant phyllodes tumor of the breast 11350610
ENSG00000035403 breast cancer 11822829
ENSG00000035403 tumor 11844069
ENSG00000035403 mesenchymal tumor 12039949
ENSG00000035403 colon cancer 12134161
ENSG00000035403 tumor 1400584
ENSG00000035403 tumor 15041417
ENSG00000035403 Cancer 15138291
ENSG00000035403 tumour 1517883
ENSG00000035403 Cancer 15579911
ENSG00000035403 tumor 16166594
ENSG00000035403 Tumor 16293970
ENSG00000035403 lung tumor 16688788
ENSG00000035403 tumor 17192196
ENSG00000035403 tumor 17668048
ENSG00000035403 neuroendocrine tumors 17709988
ENSG00000035403 tumor 18353764
ENSG00000035403 tumor 18571811
ENSG00000035403 breast cancer 19036157
ENSG00000035403 cancer 19110481
ENSG00000035403 tumours 19367286
ENSG00000035403 tumor 19516963
ENSG00000035403 tumour 20655620
ENSG00000035403 tumor 20658469
ENSG00000035403 colon cancer 20957335
ENSG00000035403 colon cancer 20959118
ENSG00000035403 tumor 21076462
ENSG00000035403 prostate cancer 21171262
ENSG00000035403 tumor 2129221
ENSG00000035403 prostate cancer 21294127
ENSG00000035403 cancer 21931851
ENSG00000035403 pancreatic cancer 22078386
ENSG00000035403 GBM 22158841
ENSG00000035403 tumors 22495828
ENSG00000035403 prostate cancer 22531786
ENSG00000035403 inflammatory myofibroblastic tumor 22614325
ENSG00000035403 cancer 22709580
ENSG00000035403 pancreatic cancer 22940724
ENSG00000035403 tumor 22977553
ENSG00000035403 tumor 23037806
ENSG00000035403 metastatic cancer 23389630
ENSG00000035403 uterine cancer 23454583
ENSG00000035403 tumour 23494917
ENSG00000035403 colon cancer 23627409
ENSG00000035403 cancer 23736792
ENSG00000035403 tumour 24179441
ENSG00000035403 tumor 24189147
ENSG00000035403 colorectal cancers 24723436
ENSG00000035403 cancer 25181322
ENSG00000035403 tumor 25183785
ENSG00000035403 tumour 25241147
ENSG00000035403 lung cancer 25249619
ENSG00000035403 tumor 25340585
ENSG00000035403 cancer 25435429
ENSG00000035403 tumor 25449281
ENSG00000035403 colorectal cancer 25496021
ENSG00000035403 cancer 25613320
ENSG00000035403 tumor 25625310
ENSG00000035403 prostate cancer 25667921
ENSG00000035403 cancer 25880222
ENSG00000035403 prostate cancer 25997717
ENSG00000035403 cancers 26070562
ENSG00000035403 breast cancer 26595523
ENSG00000035403 tumors 26650627
ENSG00000035403 tumor 26700961
ENSG00000035403 cancer 26728462
ENSG00000035403 breast cancer 26909293
ENSG00000035403 tumors 26972595
ENSG00000035403 tumor 26978651
ENSG00000035403 GBM 27108713
ENSG00000035403 tumor 27189099
ENSG00000035403 lung cancer 27499095
ENSG00000035403 cancer 27698798
ENSG00000035403 cancer 27731629
ENSG00000035403 prostate cancer 27749937
ENSG00000035403 breast cancer 28266545
ENSG00000035403 breast tumor 28376104
ENSG00000035403 bladder cancer 28552713
ENSG00000035403 tumor 28592633
ENSG00000035403 cancer 28825915
ENSG00000035403 tumor 28877984
ENSG00000035403 breast cancer 29133485
ENSG00000035403 prostate cancer 29137275
ENSG00000035403 Tumor 29158506
ENSG00000035403 tumors 29196603
ENSG00000035403 AML 29285262
ENSG00000035403 tumor 29348142
ENSG00000035403 GBM 29497511
ENSG00000035403 tumor 29507698
ENSG00000035403 cancer 29771639
ENSG00000035403 tumor 29854771
ENSG00000035403 lung cancer 29899821
ENSG00000035403 pancreatic cancer 29913236
ENSG00000035403 prostate cancer 29992322
ENSG00000035403 breast cancer 30003069
ENSG00000035403 breast cancer 30022044
ENSG00000035403 tumors 30042442
ENSG00000035403 tumors 30061623
ENSG00000035403 cancer 30067509
ENSG00000035403 GBM 30250198
ENSG00000035403 tumor 30301189
ENSG00000035403 tumors 30386596
ENSG00000035403 breast cancer 30548720
ENSG00000035403 tumors 30656488
ENSG00000035403 bladder cancers 30878701
ENSG00000035403 non-small cell lung cancer 30947597
ENSG00000035403 Tumor 30948840
ENSG00000035403 gastric cancer 30989694
ENSG00000035403 tumor 31106200
ENSG00000035403 pancreatic cancer 31255446
ENSG00000035403 breast cancer 31261642
ENSG00000035403 tumor 31269666
ENSG00000035403 cancer 31571309
ENSG00000035403 tumor 3920222
ENSG00000035403 tumor 6206076
ENSG00000035403 tumor 7521845
ENSG00000035403 tumors 7578394
ENSG00000035403 cancer 7578395
ENSG00000035403 tumor 7593207
ENSG00000035403 tumor 8089100
ENSG00000035403 tumor 8621270
ENSG00000035403 tumor 8639463
ENSG00000035403 tumor 8641669
ENSG00000035403 tumor 9021702
ENSG00000035403 tumor 9065583
ENSG00000035403 tumor 9368594
ENSG00000035403 tumor 9385927
ENSG00000035403 tumor 9434630
ENSG00000035403 cancer 9538132
ENSG00000035403 tumor 9819562
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000035403 SARC 0.0094 low
ENSG00000035403 STAD 0.044 high
ENSG00000035403 PAAD 0.00026 high
ENSG00000035403 UCEC 0.0064 high
ENSG00000035403 LGG 0.0017 high
ENSG00000035403 LUSC 0.014 high
ENSG00000035403 HNSC 0.01 high
ENSG00000035403 READ 0.014 low
ENSG00000035403 KIRP 0.0023 high
ENSG00000035403 KICH 0.0084 high
ENSG00000035403 LUAD 0.0046 high
ENSG00000035403 THYM 0.0049 high
ENSG00000035403 ESCA 0.0041 low
ENSG00000035403 KIRC 0.0085 low
ENSG00000035403 TGCT 0.035 high
ENSG00000035403 BLCA 0.001 high
ENSG00000035403 LAML 0.00034 high
ENSG00000035403 SKCM 0.049 high
ENSG00000035403 CESC 0.018 high
ENSG00000035403 LIHC 0.0024 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000035403 SARC Del 0.645713 0.117954 0.570976 0.544747
ENSG00000035403 THCA Del 1.956122 0.014754 0.506030 0.022044
ENSG00000035403 STAD Amp 2.447361 0.181252 0.575533 0.199546
ENSG00000035403 UCEC Amp 2.701354 0.145792 0.727794 0.235622