Ensembl ID ENSG00000029993 Gene ID 3149 Accession 5004
Gene Symbol HMGB3 Alias HMG4;HMG-4;HMG2A;HMG-2a Full Name high mobility group box 3
Position X : 150980509 - 150990771 Length 10263 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

ENSG00000029993 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000029993 HMGB3 1.26 3.94e-23 HNSC
ENSG00000029993 HMGB3 1.97 9.42e-25 BLCA
ENSG00000029993 HMGB3 2.43 4.95e-115 BRCA
ENSG00000029993 HMGB3 0.67 1.46e-12 COAD
ENSG00000029993 HMGB3 1.46 4.77e-21 KICH
ENSG00000029993 HMGB3 2.58 1.20e-70 LUSC
ENSG00000029993 HMGB3 0.67 1.14e-15 PRAD
ENSG00000029993 HMGB3 1.54 1.03e-31 KIRP
ENSG00000029993 HMGB3 1.65 1.20e-23 STAD
ENSG00000029993 HMGB3 2.18 1.42e-65 UCEC
ENSG00000029993 HMGB3 1.97 7.82e-13 ESCA
ENSG00000029993 HMGB3 3.50 3.67e-87 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000029993 HMGB3 lung cancer 16619573
ENSG00000029993 HMGB3 tumor 23326140
ENSG00000029993 HMGB3 non-small cell lung cancer 23609034
ENSG00000029993 HMGB3 Tumor 24098490
ENSG00000029993 HMGB3 gastric cancer 24338397
ENSG00000029993 HMGB3 tumor 25095979
ENSG00000029993 HMGB3 urinary bladder cancer 25647262
ENSG00000029993 HMGB3 tumor 26681200
ENSG00000029993 HMGB3 cervical cancer 26701206
ENSG00000029993 HMGB3 breast cancer 27363334
ENSG00000029993 HMGB3 Gastric Cancer 27774979
ENSG00000029993 HMGB3 Cancer 28069585
ENSG00000029993 HMGB3 colorectal cancer 28678825
ENSG00000029993 HMGB3 cancer 29196733
ENSG00000029993 HMGB3 cancer 30018810
ENSG00000029993 HMGB3 liver cancer 30166860
ENSG00000029993 HMGB3 cancers 30232806
ENSG00000029993 HMGB3 tumor 30343649
ENSG00000029993 HMGB3 tumor 30446524
ENSG00000029993 HMGB3 cancer 30538547
ENSG00000029993 HMGB3 cancers 30543931
ENSG00000029993 HMGB3 non-small-cell lung cancer 30623409
ENSG00000029993 HMGB3 bladder cancer 30639441
ENSG00000029993 HMGB3 ovarian cancer 31061066
ENSG00000029993 HMGB3 tumor 31213919
ENSG00000029993 HMGB3 cervical cancer 31423246
ENSG00000029993 HMGB3 colorectal cancer 31581454
ENSG00000029993 HMGB3 gastric cancer 31621076
ENSG00000029993 HMGB3 breast cancer 31773719
ENSG00000029993 HMGB3 GBM 31858556
ENSG00000029993 HMGB3 tumor 31980218
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000029993 HMGB3 MESO 0.016 high
ENSG00000029993 HMGB3 STAD 0.036 low
ENSG00000029993 HMGB3 CHOL 0.031 high
ENSG00000029993 HMGB3 UVM 0.00024 high
ENSG00000029993 HMGB3 PAAD 0.041 high
ENSG00000029993 HMGB3 UCEC 0.00033 high
ENSG00000029993 HMGB3 ACC 0.02 high
ENSG00000029993 HMGB3 LGG 0.00064 high
ENSG00000029993 HMGB3 LUSC 0.011 low
ENSG00000029993 HMGB3 HNSC 0.044 high
ENSG00000029993 HMGB3 KIRP 0.0043 low
ENSG00000029993 HMGB3 KICH 0.023 high
ENSG00000029993 HMGB3 LUAD 0.035 low
ENSG00000029993 HMGB3 THYM 0.0096 low
ENSG00000029993 HMGB3 BRCA 0.0082 high
ENSG00000029993 HMGB3 COAD 0.046 high
ENSG00000029993 HMGB3 ESCA 0.013 high
ENSG00000029993 HMGB3 OV 0.00016 low
ENSG00000029993 HMGB3 KIRC 0.00018 high
ENSG00000029993 HMGB3 PRAD 0.034 high
ENSG00000029993 HMGB3 LAML 0.003 low
ENSG00000029993 HMGB3 GBM 0.0047 low
ENSG00000029993 HMGB3 SKCM 0.0011 high
ENSG00000029993 HMGB3 CESC 0.034 low
ENSG00000029993 HMGB3 LIHC 0.00071 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency