Ensembl ID ENSG00000025796 Gene ID 11231 Accession 21082
Gene Symbol SEC63 Alias ERdj2;PCLD2;SEC63L;DNAJC23;PRO2507 Full Name SEC63 homolog, protein translocation regulator
Position 6 : 107867756 - 107958208 Length 90453 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

ENSG00000025796 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000025796 SEC63 tumor 12097267
ENSG00000025796 SEC63 cancers 17071140
ENSG00000025796 SEC63 renal cancer 28986523
ENSG00000025796 SEC63 colorectal cancers 29263911
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000025796 SEC63 SARC 0.0026 high
ENSG00000025796 SEC63 UVM 0.012 high
ENSG00000025796 SEC63 ACC 0.035 high
ENSG00000025796 SEC63 LGG 0.00075 low
ENSG00000025796 SEC63 LUSC 0.029 high
ENSG00000025796 SEC63 HNSC 0.0041 high
ENSG00000025796 SEC63 KICH 0.0017 high
ENSG00000025796 SEC63 THYM 0.0012 low
ENSG00000025796 SEC63 BRCA 0.00025 high
ENSG00000025796 SEC63 KIRC 0.006 low
ENSG00000025796 SEC63 BLCA 0.049 high
ENSG00000025796 SEC63 LAML 0.023 low
ENSG00000025796 SEC63 GBM 0.00078 low
ENSG00000025796 SEC63 CESC 0.00034 high
ENSG00000025796 SEC63 LIHC 0.013 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000025796 SEC63 LUAD Del 1.300686 0.059588 0.376291 0.511628
ENSG00000025796 SEC63 SKCM Del 4.293021 0.114755 0.563244 0.577657
ENSG00000025796 SEC63 LIHC Del 2.033753 0.086319 0.601982 0.345946
ENSG00000025796 SEC63 DLBC Del 3.843504 0.295473 0.598601 0.395833
ENSG00000025796 SEC63 BLCA Del 4.020994 0.123390 0.390410 0.455882
ENSG00000025796 SEC63 BRCA Amp 3.687835 0.194758 0.716208 0.174074
ENSG00000025796 SEC63 BRCA Del 7.244243 0.103353 0.496407 0.315741
ENSG00000025796 SEC63 STAD Del 1.358480 0.070213 0.393687 0.183673
ENSG00000025796 SEC63 PRAD Del 42.304739 0.300809 0.540310 0.327236
ENSG00000025796 SEC63 MESO Del 0.939774 0.133154 0.524032 0.459770
ENSG00000025796 SEC63 KIRC Del 2.189241 0.033628 0.446680 0.272727
ENSG00000025796 SEC63 OV Del 3.642232 0.228871 0.622405 0.538860