Ensembl ID ENSG00000023228 Gene ID 4719 Accession 7707
Gene Symbol NDUFS1 Alias CI-75k;MC1DN5;CI-75Kd;PRO1304 Full Name NADH:ubiquinone oxidoreductase core subunit S1
Position 2 : 206114817 - 206159509 Length 44693 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

ENSG00000023228 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000023228 NDUFS1 -1.2 2.33e-55 KIRC
ENSG00000023228 NDUFS1 -1.1 1.49e-44 HNSC
ENSG00000023228 NDUFS1 -0.5 1.65e-18 COAD
ENSG00000023228 NDUFS1 -0.8 7.20e-13 GBM
ENSG00000023228 NDUFS1 -0.6 3.39e-15 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000023228 NDUFS1 lung cancer 27516145
ENSG00000023228 NDUFS1 Cancer 28063846
ENSG00000023228 NDUFS1 tumour 30504842
ENSG00000023228 NDUFS1 tumour 31513013
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000023228 NDUFS1 MESO 0.013 low
ENSG00000023228 NDUFS1 SARC 0.043 high
ENSG00000023228 NDUFS1 UVM 0.0022 high
ENSG00000023228 NDUFS1 PAAD 0.025 high
ENSG00000023228 NDUFS1 UCEC 0.023 low
ENSG00000023228 NDUFS1 LGG 0.024 low
ENSG00000023228 NDUFS1 READ 0.0062 low
ENSG00000023228 NDUFS1 KIRP 0.0012 low
ENSG00000023228 NDUFS1 KICH 0.024 high
ENSG00000023228 NDUFS1 LUAD 0.039 high
ENSG00000023228 NDUFS1 THYM 0.046 high
ENSG00000023228 NDUFS1 BRCA 0.00017 high
ENSG00000023228 NDUFS1 COAD 0.015 low
ENSG00000023228 NDUFS1 PRAD 0.016 low
ENSG00000023228 NDUFS1 BLCA 0.02 high
ENSG00000023228 NDUFS1 LAML 0.028 low
ENSG00000023228 NDUFS1 GBM 0.0018 low
ENSG00000023228 NDUFS1 SKCM 0.021 high
ENSG00000023228 NDUFS1 LIHC 0.022 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000023228 NDUFS1 LUSC Del 6.248595 0.123824 0.366030 0.219561
ENSG00000023228 NDUFS1 CESC Del 24.950360 0.287361 0.526170 0.352542
ENSG00000023228 NDUFS1 KIRP Amp 1.259300 0.069152 0.552440 0.163194
ENSG00000023228 NDUFS1 KIRP Del 0.780948 0.027818 0.580522 0.031250
ENSG00000023228 NDUFS1 SARC Del 0.701077 0.120060 0.443577 0.315175
ENSG00000023228 NDUFS1 HNSC Del 17.720038 0.160946 0.372988 0.260536
ENSG00000023228 NDUFS1 BLCA Del 7.899480 0.161867 0.398257 0.392157
ENSG00000023228 NDUFS1 KIRC Del 1.245085 0.028297 0.527177 0.053030