Ensembl ID ENSG00000020922 Gene ID 4361 Accession 7230
Gene Symbol MRE11 Alias ATLD;HNGS1;MRE11A;MRE11B Full Name MRE11 homolog, double strand break repair nuclease
Position 11 : 94415570 - 94493885 Length 78316 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

ENSG00000020922 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000020922 0.80 4.60e-16 COAD
ENSG00000020922 0.58 1.13e-17 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000020922 cancer 10362365
ENSG00000020922 tumor 10783165
ENSG00000020922 cancer 11196167
ENSG00000020922 cancer 11544181
ENSG00000020922 cancers 11850399
ENSG00000020922 breast tumors 12112527
ENSG00000020922 tumours 14511253
ENSG00000020922 cancer 15048091
ENSG00000020922 gastric cancer 15319296
ENSG00000020922 malignant tumours 15509680
ENSG00000020922 cancer 15964827
ENSG00000020922 breast cancer 16091150
ENSG00000020922 tumours 16288216
ENSG00000020922 cancers 16417627
ENSG00000020922 cancer 16752129
ENSG00000020922 AML 16914901
ENSG00000020922 tumours 17384679
ENSG00000020922 HNSCC 17492757
ENSG00000020922 tumours 17534377
ENSG00000020922 tumor 17558733
ENSG00000020922 cancer 18056440
ENSG00000020922 tumor 18256278
ENSG00000020922 breast cancer 18356318
ENSG00000020922 breast cancer 18553220
ENSG00000020922 tumor 18606567
ENSG00000020922 bladder cancer 18638378
ENSG00000020922 tumors 18765539
ENSG00000020922 colorectal cancer 18830935
ENSG00000020922 tumours 19081245
ENSG00000020922 tumors 19179424
ENSG00000020922 tumour 19344493
ENSG00000020922 breast cancer 19383352
ENSG00000020922 ovarian cancer 19584272
ENSG00000020922 breast cancer 19714462
ENSG00000020922 cancers 19942681
ENSG00000020922 cancer 20015360
ENSG00000020922 tumours 20148879
ENSG00000020922 ovarian cancer 20164540
ENSG00000020922 cancer 20679231
ENSG00000020922 bladder cancer 20843819
ENSG00000020922 colorectal cancers 21300766
ENSG00000020922 breast cancer 21409565
ENSG00000020922 tumor 21441914
ENSG00000020922 tumour 21466987
ENSG00000020922 Breast cancer 21599985
ENSG00000020922 lung cancer 21739480
ENSG00000020922 ovarian cancer 21799032
ENSG00000020922 tumor 22065898
ENSG00000020922 bladder cancer 22166496
ENSG00000020922 cancer 22644231
ENSG00000020922 cancer 22743550
ENSG00000020922 prostate cancer 22864661
ENSG00000020922 breast cancer 22875744
ENSG00000020922 breast cancer 22914783
ENSG00000020922 bladder cancer 23046361
ENSG00000020922 tumor 23063122
ENSG00000020922 prostate cancer 23361058
ENSG00000020922 colorectal cancers 23382697
ENSG00000020922 cancer 23390603
ENSG00000020922 oral cancer 23437280
ENSG00000020922 breast cancer 23586058
ENSG00000020922 Endometrial Cancers 23755103
ENSG00000020922 cancer 23912341
ENSG00000020922 pancreatic cancer 23954013
ENSG00000020922 breast cancer 24025454
ENSG00000020922 head and neck cancers 24079363
ENSG00000020922 cancer 24093751
ENSG00000020922 colorectal cancer 24215868
ENSG00000020922 colorectal cancer 24338765
ENSG00000020922 cancer 24484288
ENSG00000020922 colon cancer 24577941
ENSG00000020922 tumors 24616882
ENSG00000020922 bladder cancer 24623370
ENSG00000020922 tumours 24625413
ENSG00000020922 bladder cancer 24652204
ENSG00000020922 breast cancer 24678344
ENSG00000020922 breast cancer 24747666
ENSG00000020922 tumor 24752797
ENSG00000020922 cancer 24763289
ENSG00000020922 Breast Cancer 24894818
ENSG00000020922 tumours 24927325
ENSG00000020922 colon cancer 25310185
ENSG00000020922 breast cancer 25485873
ENSG00000020922 breast cancer 25566853
ENSG00000020922 tumors 25918678
ENSG00000020922 breast cancer 25992773
ENSG00000020922 cancer 26198537
ENSG00000020922 breast cancer 26436112
ENSG00000020922 cancer 26438152
ENSG00000020922 cancer 26455503
ENSG00000020922 breast cancer 26534844
ENSG00000020922 triple-negative breast cancer 26577420
ENSG00000020922 tumor 26676960
ENSG00000020922 colon cancer 26735576
ENSG00000020922 breast cancer 26787654
ENSG00000020922 ovarian cancer 27144062
ENSG00000020922 breast cancer 27318168
ENSG00000020922 cancer 27335639
ENSG00000020922 tumors 27374179
ENSG00000020922 cancer 27738139
ENSG00000020922 hereditary breast cancer 27783279
ENSG00000020922 Gastric Cancer 27798884
ENSG00000020922 Rectal Cancer 27930716
ENSG00000020922 epithelial ovarian cancer 28073364
ENSG00000020922 GBMs 28094268
ENSG00000020922 Breast Cancer 28133604
ENSG00000020922 gastric cancer 28144288
ENSG00000020922 ovarian cancer 28250960
ENSG00000020922 tumors 28346378
ENSG00000020922 Bladder Cancer 28363998
ENSG00000020922 cancer 28436950
ENSG00000020922 colorectal cancer 28544645
ENSG00000020922 Familial Breast Cancer 28559769
ENSG00000020922 cancers 28628639
ENSG00000020922 bladder cancer 28641314
ENSG00000020922 breast cancer 28649662
ENSG00000020922 cancer 28819025
ENSG00000020922 bladder cancer 28839000
ENSG00000020922 breast cancer 28891274
ENSG00000020922 tumour 28967905
ENSG00000020922 tumor 29053959
ENSG00000020922 tumor 29059438
ENSG00000020922 oral cancer 29165875
ENSG00000020922 tumor 29189711
ENSG00000020922 breast cancer 29207607
ENSG00000020922 cancer 29338689
ENSG00000020922 breast cancer 29361783
ENSG00000020922 breast cancer 29368209
ENSG00000020922 susceptibility to breast cancer 29678143
ENSG00000020922 Breast cancer 29867559
ENSG00000020922 hereditary breast and ovarian cancer 29879995
ENSG00000020922 ovarian cancer 29928469
ENSG00000020922 cancer 29973640
ENSG00000020922 bladder cancer 29991697
ENSG00000020922 tumors 30166519
ENSG00000020922 tumor 30176843
ENSG00000020922 tumors 30234181
ENSG00000020922 Cancer 30283497
ENSG00000020922 DLBCL 30298948
ENSG00000020922 prostate cancer 30305041
ENSG00000020922 breast cancer 30370249
ENSG00000020922 breast cancer 30521029
ENSG00000020922 bladder cancer 30561437
ENSG00000020922 cancer 30584599
ENSG00000020922 tumors 30612738
ENSG00000020922 Colorectal Cancer 30769804
ENSG00000020922 Bladder Cancer 30885775
ENSG00000020922 cancer 31214250
ENSG00000020922 tumours 31221177
ENSG00000020922 cancer 31261657
ENSG00000020922 Cancer 31273614
ENSG00000020922 cancer 31318974
ENSG00000020922 breast cancer 31353207
ENSG00000020922 tumor 31413753
ENSG00000020922 tumor 31488179
ENSG00000020922 bladder cancer 31766169
ENSG00000020922 cancer 31767017
ENSG00000020922 Bladder Cancer 31942442
ENSG00000020922 cancer 8530104
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000020922 CHOL 0.0084 low
ENSG00000020922 UVM 0.03 high
ENSG00000020922 PAAD 0.034 high
ENSG00000020922 UCEC 0.0021 high
ENSG00000020922 THCA 0.018 high
ENSG00000020922 LUSC 0.04 low
ENSG00000020922 READ 0.00033 low
ENSG00000020922 KIRP 0.0026 high
ENSG00000020922 KICH 0.016 high
ENSG00000020922 PCPG 0.015 high
ENSG00000020922 THYM 0.00097 low
ENSG00000020922 BRCA 0.0064 high
ENSG00000020922 COAD 0.046 high
ENSG00000020922 DLBC 0.028 high
ENSG00000020922 PRAD 0.0011 high
ENSG00000020922 BLCA 0.031 low
ENSG00000020922 SKCM 0.015 low
ENSG00000020922 LIHC 0.0034 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000020922 LUSC Del 2.233510 0.085791 0.357029 0.313373
ENSG00000020922 CESC Amp 0.762300 0.130820 0.619200 0.098305
ENSG00000020922 CESC Del 0.868728 0.070464 0.526041 0.389831
ENSG00000020922 KIRP Del 1.512391 0.034961 0.562933 0.093750
ENSG00000020922 SARC Del 1.607088 0.147443 0.544061 0.377432
ENSG00000020922 SKCM Amp 1.020713 0.130728 0.744693 0.106267
ENSG00000020922 SKCM Del 3.098816 0.100890 0.502701 0.430518
ENSG00000020922 HNSC Del 5.755881 0.097065 0.429360 0.406130
ENSG00000020922 TGCT Del 0.911169 0.060628 0.458293 0.793333
ENSG00000020922 BRCA Del 13.428681 0.127312 0.509962 0.407407
ENSG00000020922 OV Amp 0.902900 0.335486 0.673950 0.336788