Ensembl ID ENSG00000011304 Gene ID 5725 Accession 9583
Gene Symbol PTBP1 Alias PTB;PTB2;PTB3;PTB4;pPTB;HNRPI;PTB-1;PTB-T;HNRNPI;HNRNP-I Full Name polypyrimidine tract binding protein 1
Position 19 : 797075 - 812327 Length 15253 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

ENSG00000011304 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000011304 PTBP1 0.28 3.28e-15 KIRC
ENSG00000011304 PTBP1 0.66 3.40e-16 BLCA
ENSG00000011304 PTBP1 0.66 3.51e-96 BRCA
ENSG00000011304 PTBP1 0.47 4.01e-14 COAD
ENSG00000011304 PTBP1 0.64 6.88e-36 LUSC
ENSG00000011304 PTBP1 0.28 1.79e-11 PRAD
ENSG00000011304 PTBP1 1.93 1.46e-21 GBM
ENSG00000011304 PTBP1 0.57 1.25e-21 UCEC
ENSG00000011304 PTBP1 0.38 4.63e-12 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000011304 PTBP1 tumours 19506066
ENSG00000011304 PTBP1 tumor 21194727
ENSG00000011304 PTBP1 tumor 21976412
ENSG00000011304 PTBP1 cancer 22911749
ENSG00000011304 PTBP1 tumor 24286314
ENSG00000011304 PTBP1 breast cancer 24418892
ENSG00000011304 PTBP1 tumor 24457952
ENSG00000011304 PTBP1 ovarian cancer 24743263
ENSG00000011304 PTBP1 ovarian cancer 25079003
ENSG00000011304 PTBP1 cancer 25294838
ENSG00000011304 PTBP1 Colorectal Cancer 25904505
ENSG00000011304 PTBP1 cancer 25908786
ENSG00000011304 PTBP1 breast cancer 25913416
ENSG00000011304 PTBP1 pancreatic cancer 26234680
ENSG00000011304 PTBP1 ovarian tumors 26336992
ENSG00000011304 PTBP1 cancer 26416554
ENSG00000011304 PTBP1 tumor 26683771
ENSG00000011304 PTBP1 cancer 26728853
ENSG00000011304 PTBP1 tumor 26860615
ENSG00000011304 PTBP1 colorectal tumors 26980745
ENSG00000011304 PTBP1 cancer 27041567
ENSG00000011304 PTBP1 cancer 27367564
ENSG00000011304 PTBP1 colon cancer 27453209
ENSG00000011304 PTBP1 tumor 27513449
ENSG00000011304 PTBP1 tumor 27696637
ENSG00000011304 PTBP1 pancreatic cancer 27785603
ENSG00000011304 PTBP1 colorectal cancer 27836735
ENSG00000011304 PTBP1 cancer 27840950
ENSG00000011304 PTBP1 brain tumor 28024117
ENSG00000011304 PTBP1 Bladder Cancer 28106737
ENSG00000011304 PTBP1 colorectal cancer 28296893
ENSG00000011304 PTBP1 tumor 28337374
ENSG00000011304 PTBP1 cancer 28374191
ENSG00000011304 PTBP1 bladder cancer 28380435
ENSG00000011304 PTBP1 colorectal cancer 28404950
ENSG00000011304 PTBP1 pancreatic cancer 28573168
ENSG00000011304 PTBP1 tumor 28801479
ENSG00000011304 PTBP1 colon cancer 28804724
ENSG00000011304 PTBP1 cancer 28981396
ENSG00000011304 PTBP1 breast cancer 28990063
ENSG00000011304 PTBP1 cancer 29361709
ENSG00000011304 PTBP1 GBM 29415469
ENSG00000011304 PTBP1 colorectal cancer 29499929
ENSG00000011304 PTBP1 tumor 29512730
ENSG00000011304 PTBP1 tumor 29592812
ENSG00000011304 PTBP1 GBM 29695138
ENSG00000011304 PTBP1 cancer 29748555
ENSG00000011304 PTBP1 breast cancer 29856478
ENSG00000011304 PTBP1 tumor 29990503
ENSG00000011304 PTBP1 Bladder Cancer 30012566
ENSG00000011304 PTBP1 colon cancer 30219676
ENSG00000011304 PTBP1 Colorectal Tumors 30279379
ENSG00000011304 PTBP1 colon cancer 30309622
ENSG00000011304 PTBP1 cancer 30318443
ENSG00000011304 PTBP1 cancer 30319972
ENSG00000011304 PTBP1 cancer 30327198
ENSG00000011304 PTBP1 cancer 30388407
ENSG00000011304 PTBP1 cancer 30548479
ENSG00000011304 PTBP1 cancer 30568224
ENSG00000011304 PTBP1 GBM 30644073
ENSG00000011304 PTBP1 bladder cancer 30688932
ENSG00000011304 PTBP1 cervical cancer 30696738
ENSG00000011304 PTBP1 bladder cancer 30742945
ENSG00000011304 PTBP1 cancer 30930112
ENSG00000011304 PTBP1 cancer 30962446
ENSG00000011304 PTBP1 lung cancer 31075540
ENSG00000011304 PTBP1 cancer 31130994
ENSG00000011304 PTBP1 tumor 31301177
ENSG00000011304 PTBP1 bladder cancer 31304601
ENSG00000011304 PTBP1 cancer 31461477
ENSG00000011304 PTBP1 tumor 31623628
ENSG00000011304 PTBP1 breast cancer 31666932
ENSG00000011304 PTBP1 lung tumor 31729427
ENSG00000011304 PTBP1 tumor 31862871
ENSG00000011304 PTBP1 liver cancer 31919425
ENSG00000011304 PTBP1 cancer 31964396
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000011304 PTBP1 MESO 0.00047 high
ENSG00000011304 PTBP1 SARC 0.00035 high
ENSG00000011304 PTBP1 STAD 0.0076 low
ENSG00000011304 PTBP1 CHOL 0.034 low
ENSG00000011304 PTBP1 READ 0.016 low
ENSG00000011304 PTBP1 KIRP 0.0011 high
ENSG00000011304 PTBP1 KICH 0.018 high
ENSG00000011304 PTBP1 LUAD 0.00056 high
ENSG00000011304 PTBP1 THYM 0.006 low
ENSG00000011304 PTBP1 BRCA 0.01 low
ENSG00000011304 PTBP1 COAD 0.0031 high
ENSG00000011304 PTBP1 OV 0.03 low
ENSG00000011304 PTBP1 PRAD 0.0046 low
ENSG00000011304 PTBP1 TGCT 0.045 low
ENSG00000011304 PTBP1 BLCA 0.018 low
ENSG00000011304 PTBP1 SKCM 0.0012 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000011304 PTBP1 LUSC Del 11.591084 0.160345 0.362116 0.471058
ENSG00000011304 PTBP1 LUAD Del 5.131577 0.094207 0.353237 0.529070
ENSG00000011304 PTBP1 LGG Amp 3.887579 0.086956 0.371460 0.251462
ENSG00000011304 PTBP1 CESC Del 16.625789 0.229375 0.497950 0.355932
ENSG00000011304 PTBP1 READ Del 0.637830 0.068240 0.352942 0.206061
ENSG00000011304 PTBP1 COAD Del 1.975833 0.055933 0.387226 0.133038
ENSG00000011304 PTBP1 UCS Del 12.687889 0.811988 0.623498 0.839286
ENSG00000011304 PTBP1 SARC Amp 1.013713 0.277980 0.670207 0.338521
ENSG00000011304 PTBP1 SARC Del 5.138254 0.219058 0.486088 0.233463
ENSG00000011304 PTBP1 GBM Amp 1.571915 0.083613 0.541405 0.426343
ENSG00000011304 PTBP1 PAAD Del 1.977711 0.070608 0.352873 0.195652
ENSG00000011304 PTBP1 ESCA Del 3.974428 0.177696 0.352173 0.505435
ENSG00000011304 PTBP1 SKCM Del 1.968689 0.086140 0.341018 0.283379
ENSG00000011304 PTBP1 HNSC Del 16.510150 0.154931 0.362405 0.329502
ENSG00000011304 PTBP1 LIHC Del 6.995980 0.141037 0.460272 0.245946
ENSG00000011304 PTBP1 BLCA Del 5.941202 0.143027 0.342924 0.352941
ENSG00000011304 PTBP1 BRCA Del 29.083302 0.174427 0.407321 0.333333
ENSG00000011304 PTBP1 STAD Del 2.211282 0.081260 0.344009 0.328798
ENSG00000011304 PTBP1 UCEC Del 41.367151 0.251480 0.588474 0.263451
ENSG00000011304 PTBP1 OV Del 137.588419 0.947459 0.650037 0.882556