Ensembl ID ENSG00000005007 Gene ID 5976 Accession 9962
Gene Symbol UPF1 Alias UTF;HUPF1;NORF1;RENT1;smg-2;pNORF1 Full Name UPF1 RNA helicase and ATPase
Position 19 : 18831959 - 18868230 Length 36272 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

ENSG00000005007 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000005007 UPF1 -0.5 1.35e-33 KIRC
ENSG00000005007 UPF1 0.30 7.41e-14 BRCA
ENSG00000005007 UPF1 -0.5 1.55e-19 KIRP
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000005007 UPF1 tumour 18427545
ENSG00000005007 UPF1 tumor 18612427
ENSG00000005007 UPF1 gastric cancer 19563644
ENSG00000005007 UPF1 cancer 23881279
ENSG00000005007 UPF1 tumors 24859531
ENSG00000005007 UPF1 lung cancer 25520033
ENSG00000005007 UPF1 tumor 26759305
ENSG00000005007 UPF1 tumor 28554132
ENSG00000005007 UPF1 urinary bladder cancer 28827400
ENSG00000005007 UPF1 Gastric Cancer 28942451
ENSG00000005007 UPF1 tumors 29510736
ENSG00000005007 UPF1 tumor 30628676
ENSG00000005007 UPF1 colorectal cancer 30662328
ENSG00000005007 UPF1 Colorectal Cancer 30719122
ENSG00000005007 UPF1 tumor 31040354
ENSG00000005007 UPF1 colorectal cancer 31253658
ENSG00000005007 UPF1 tumour 31264769
ENSG00000005007 UPF1 tumor 31427569
ENSG00000005007 UPF1 Cancer 31718065
ENSG00000005007 UPF1 tumor 31799670
ENSG00000005007 UPF1 cancer 31819156
ENSG00000005007 UPF1 ovarian cancer 31858532
ENSG00000005007 UPF1 thyroid cancer 31858555
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000005007 UPF1 STAD 0.034 low
ENSG00000005007 UPF1 UCEC 8e-04 low
ENSG00000005007 UPF1 THCA 0.0085 low
ENSG00000005007 UPF1 ACC 0.0053 high
ENSG00000005007 UPF1 LUAD 0.038 high
ENSG00000005007 UPF1 COAD 0.017 high
ENSG00000005007 UPF1 OV 0.0055 high
ENSG00000005007 UPF1 PRAD 0.02 high
ENSG00000005007 UPF1 BLCA 0.0074 low
ENSG00000005007 UPF1 LAML 0.00017 high
ENSG00000005007 UPF1 SKCM 0.03 high
ENSG00000005007 UPF1 CESC 0.041 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000005007 UPF1 UCEC Amp 3.832816 0.164506 0.772431 0.146568
ENSG00000005007 UPF1 OV Amp 7.040241 0.492606 0.793448 0.476684