Ensembl ID ENSG00000004478 Gene ID 2288 Accession 3720
Gene Symbol FKBP4 Alias HBI;p52;Hsp56;FKBP51;FKBP52;FKBP59;PPIase Full Name FKBP prolyl isomerase 4
Position 12 : 2794970 - 2805423 Length 10454 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]

ENSG00000004478 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000004478 FKBP4 -0.8 2.86e-39 KIRC
ENSG00000004478 FKBP4 1.47 1.05e-77 BRCA
ENSG00000004478 FKBP4 2.13 2.09e-86 LUSC
ENSG00000004478 FKBP4 0.82 6.44e-11 UCEC
ENSG00000004478 FKBP4 1.15 9.14e-23 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000004478 FKBP4 breast cancer 10718488
ENSG00000004478 FKBP4 breast cancer 11374893
ENSG00000004478 FKBP4 ovarian cancer 11788994
ENSG00000004478 FKBP4 cancers 1315716
ENSG00000004478 FKBP4 colon cancer 15004035
ENSG00000004478 FKBP4 prostate cancer 17615153
ENSG00000004478 FKBP4 cancer 18606492
ENSG00000004478 FKBP4 cancer 19228724
ENSG00000004478 FKBP4 breast cancer 19584157
ENSG00000004478 FKBP4 HNSCC 20162572
ENSG00000004478 FKBP4 cancer 21514887
ENSG00000004478 FKBP4 prostate cancer 21730179
ENSG00000004478 FKBP4 cancers 21889356
ENSG00000004478 FKBP4 tumour 22068818
ENSG00000004478 FKBP4 breast cancer 22074005
ENSG00000004478 FKBP4 tumor 22080169
ENSG00000004478 FKBP4 tumors 22185463
ENSG00000004478 FKBP4 prostate cancer 22325547
ENSG00000004478 FKBP4 tumors 22362161
ENSG00000004478 FKBP4 cancer 22612312
ENSG00000004478 FKBP4 breast cancer 22888636
ENSG00000004478 FKBP4 prostate cancer 23036345
ENSG00000004478 FKBP4 breast cancer 23331018
ENSG00000004478 FKBP4 prostate cancer 23933011
ENSG00000004478 FKBP4 tumor 24829384
ENSG00000004478 FKBP4 breast cancer 24927296
ENSG00000004478 FKBP4 breast cancer 24957886
ENSG00000004478 FKBP4 neural tumors 25132599
ENSG00000004478 FKBP4 prostate cancer 25380396
ENSG00000004478 FKBP4 tumor 26074449
ENSG00000004478 FKBP4 prostate cancer 26207810
ENSG00000004478 FKBP4 prostate cancer 26728473
ENSG00000004478 FKBP4 tumour 26893500
ENSG00000004478 FKBP4 tumor 27193821
ENSG00000004478 FKBP4 Cancer 27592546
ENSG00000004478 FKBP4 tumor 28252832
ENSG00000004478 FKBP4 prostate cancer 28852180
ENSG00000004478 FKBP4 breast cancer 29113172
ENSG00000004478 FKBP4 prostate cancer 29484655
ENSG00000004478 FKBP4 tumour 29788248
ENSG00000004478 FKBP4 lymphoid tumors 2999447
ENSG00000004478 FKBP4 lymphoid tumors 2999450
ENSG00000004478 FKBP4 prostate cancer 30568592
ENSG00000004478 FKBP4 oral cancer 30641296
ENSG00000004478 FKBP4 cancer 30717249
ENSG00000004478 FKBP4 cancer 31052553
ENSG00000004478 FKBP4 tumours 31130732
ENSG00000004478 FKBP4 Tumour 31496626
ENSG00000004478 FKBP4 breast cancer 31660083
ENSG00000004478 FKBP4 cancer 31754722
ENSG00000004478 FKBP4 tumors 6302305
ENSG00000004478 FKBP4 tumor 6317183
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000004478 FKBP4 MESO 0.0032 high
ENSG00000004478 FKBP4 SARC 0.0015 high
ENSG00000004478 FKBP4 STAD 0.031 low
ENSG00000004478 FKBP4 PAAD 0.038 high
ENSG00000004478 FKBP4 UCEC 0.00067 high
ENSG00000004478 FKBP4 ACC 0.025 high
ENSG00000004478 FKBP4 LGG 0.013 low
ENSG00000004478 FKBP4 LUSC 0.017 low
ENSG00000004478 FKBP4 HNSC 0.048 high
ENSG00000004478 FKBP4 KIRP 0.00083 high
ENSG00000004478 FKBP4 KICH 0.0063 high
ENSG00000004478 FKBP4 PCPG 0.009 low
ENSG00000004478 FKBP4 THYM 0.0031 low
ENSG00000004478 FKBP4 BRCA 0.0017 high
ENSG00000004478 FKBP4 COAD 0.0036 high
ENSG00000004478 FKBP4 ESCA 0.045 high
ENSG00000004478 FKBP4 KIRC 0.00069 high
ENSG00000004478 FKBP4 BLCA 0.02 low
ENSG00000004478 FKBP4 SKCM 2e-04 high
ENSG00000004478 FKBP4 CESC 0.013 high
ENSG00000004478 FKBP4 LIHC 0.00029 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000004478 FKBP4 LUSC Amp 1.301325 0.214358 0.603973 0.516966
ENSG00000004478 FKBP4 LUAD Del 2.112052 0.068400 0.346563 0.246124
ENSG00000004478 FKBP4 LGG Amp 9.526653 0.146397 0.786276 0.126706
ENSG00000004478 FKBP4 COAD Amp 7.071022 0.171714 0.632187 0.248337
ENSG00000004478 FKBP4 SARC Del 0.859407 0.125958 0.498807 0.291829
ENSG00000004478 FKBP4 PAAD Amp 1.758716 0.117280 0.698099 0.201087
ENSG00000004478 FKBP4 HNSC Amp 1.124771 0.127309 0.620509 0.319923
ENSG00000004478 FKBP4 TGCT Amp 19.609087 0.640349 1.700624 0.966667
ENSG00000004478 FKBP4 BRCA Amp 0.801497 0.147418 0.569325 0.250926
ENSG00000004478 FKBP4 STAD Del 0.634740 0.059411 0.401559 0.167800
ENSG00000004478 FKBP4 OV Amp 5.662348 0.464966 0.932996 0.571675